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Akademický článek

The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study

Autor: Jing Yang, Duorui Nie, Yujing Chen, Zixing Liu, Mengzhao Li, Chun Gong, Qiong Liu

Publikováno v: Frontiers in Genetics, Vol 13 (2023)

Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal associat

Externí odkaz: https://doaj.org/article/246130bf8e524ad2a457fb63822b4abf

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Akademický článek

Demethylating Agents in the Treatment of Cancer

Autor: Paul M. Howell, Jr., Zixing Liu, Hung T. Khong

Publikováno v: Pharmaceuticals, Vol 3, Iss 7, Pp 2022-2044 (2010)

Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis. Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate and induce silenced gene re-expression in malignancies. Two demethylating a

Externí odkaz: https://doaj.org/article/b41aba8600824d95ad1aa9e914981c87

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Data from B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation

Autor: Ming Tan, Oystein Fodstad, Jahn Marthin Nesland, Gunhild Mari Mælandsmo, Bin Wang, Yan Ding, Zixing Liu, Ming Zhou, Yuhua Zhao, Alexandr Kristian, Yih-Wen Chen, Christina Tekle, Hao Liu

In many types of cancer, the expression of the immunoregulatory protein B7-H3 has been associated with poor prognosis. Previously, we observed a link between B7-H3 and tumor cell migration and invasion, and in present study, we have investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0c499579780413b8f4286978a092277
https://doi.org/10.1158/1535-7163.c.6535333

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Data from Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

Autor: Ming Tan, Oystein Fodstad, Gary A. Piazza, Wensheng Lin, Yifeng Lin, Steven McClellan, Tung Vu, David C. Schmitt, Joshua B. Phillips, Zixing Liu, Ritu Arora, Luciana Madeira da Silva, Hao Liu, Sangbin Lim

B7-H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. While B7-H3 overexpression is associated with poor outcomes in multiple cancers, it also has immune-independent roles outside T cells and its precise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064abd0554c56d9595caad8a2d475c62
https://doi.org/10.1158/0008-5472.c.6508131

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Supplemental Figures S1-S9 from Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

Fig. S1: Glucose uptake and lactate production in B7-H3 knockdown Fig. S2: Growth inhibition W/O B7-H3 Fig S3: Proliferation assay in glucose deprivation. Fig. S4: Expression in B7-H3 knockdown w/o CoCl2. Fig. S5: mRNA levels. Fig. S6: Reduction of R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eb9b21202d1b0db830f93ef424dd2e
https://doi.org/10.1158/0008-5472.22411032.v1

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