MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies

Autor: Abiona, Olubukola M. ^{1, 10}, Wang, Nianshuang ^{2, 10}, Leist, Sarah R. ^{3, 10}, Schäfer, Alexandra ³, Cockrell, Adam S. ³, Wang, Lingshu ¹, Bangaru, Sandhya ⁴, Stevens, Laura ⁵, Graham, Rachel L. ³, Kocher, Jacob F. ³, Tsybovsky, Yaroslav ⁶, Kanekiyo, Masaru ¹, Kumar, Azad ¹, Morabito, Kaitlyn M. ¹, Rosen, Osnat ¹, Shi, Wei ¹, Werner, Anne ¹, Zhang, Yi ¹, Ziwawo, Cynthia ¹, Dzuvor, Christian K.O. ⁷, Palandjian, Charis ⁷, Eastman, Connor ⁸, Matthews, Hannah R. ⁷, Joseph, Jeswin ⁷, Chappell, James D. ⁵, Kong, Wing-Pui ¹, Mascola, John R. ¹, Ward, Andrew B. ⁴, Denison, Mark R. ⁵, Baric, Ralph ³, McLellan, Jason S. ², Graham, Barney S. ¹, Corbett-Helaire, Kizzmekia S. ^{1, 7, 9, 11, ∗}

Publikováno v: In iScience December 2024

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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness.

Autor: Corbett KS; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Edwards D; Moderna Inc., Cambridge, MA, 02139; United States of America., Leist SR; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Abiona OM; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Boyoglu-Barnum S; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Gillespie RA; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Himansu S; Moderna Inc., Cambridge, MA, 02139; United States of America., Schäfer A; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Ziwawo CT; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., DiPiazza AT; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Dinnon KH; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Elbashir SM; Moderna Inc., Cambridge, MA, 02139; United States of America., Shaw CA; Moderna Inc., Cambridge, MA, 02139; United States of America., Woods A; Moderna Inc., Cambridge, MA, 02139; United States of America., Fritch EJ; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Martinez DR; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Bock KW; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Minai M; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Nagata BM; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Hutchinson GB; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Bahl K; Moderna Inc., Cambridge, MA, 02139; United States of America., Garcia-Dominguez D; Moderna Inc., Cambridge, MA, 02139; United States of America., Ma L; Moderna Inc., Cambridge, MA, 02139; United States of America., Renzi I; Moderna Inc., Cambridge, MA, 02139; United States of America., Kong WP; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Schmidt SD; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Wang L; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Zhang Y; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Stevens LJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, 37212; United States of America., Phung E; Institute for Biomedical Sciences, George Washington University, Washington, DC 20052, United States of America., Chang LA; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Loomis RJ; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Altaras NE; Moderna Inc., Cambridge, MA, 02139; United States of America., Narayanan E; Moderna Inc., Cambridge, MA, 02139; United States of America., Metkar M; Moderna Inc., Cambridge, MA, 02139; United States of America., Presnyak V; Moderna Inc., Cambridge, MA, 02139; United States of America., Liu C; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Louder MK; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Shi W; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Leung K; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Yang ES; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., West A; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Gully KL; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Wang N; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America., Wrapp D; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America., Doria-Rose NA; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Stewart-Jones G; Moderna Inc., Cambridge, MA, 02139; United States of America., Bennett H; Moderna Inc., Cambridge, MA, 02139; United States of America., Nason MC; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Ruckwardt TJ; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., McLellan JS; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America., Denison MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, 37212; United States of America., Chappell JD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, 37212; United States of America., Moore IN; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Morabito KM; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Mascola JR; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Baric RS; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Carfi A; Moderna Inc., Cambridge, MA, 02139; United States of America., Graham BS; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Jun 11. Date of Electronic Publication: 2020 Jun 11.