Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ziv, Shulman"'
Autor:
Jonathan Zorea, Yair Motro, Roei D. Mazor, Yifat Koren Carmi, Ziv Shulman, Jamal Mahajna, Jacob Moran-Gilad, Moshe Elkabets
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Background Ovarian cancer (OC) is known for exhibiting low response rates to immune checkpoint inhibitors that activate T cells. However, immunotherapies that activate B cells have not yet been extensively explored and may be a potential tar
Externí odkaz:
https://doaj.org/article/55a4f78cd4024880a535e0d242aff914
Autor:
Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Pietro Di Lucia, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John D. Crispino, Ziv Shulman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection throug
Externí odkaz:
https://doaj.org/article/431be3cd018542aa832ba2a735ae482b
Autor:
Romano Strobelt, Julia Adler, Nir Paran, Yfat Yahalom-Ronen, Sharon Melamed, Boaz Politi, Ziv Shulman, Dominik Schmiedel, Yosef Shaul
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of the COVID-19 pandemic. More than 274 million individuals have suffered from COVID-19 and over five million people have died from this disease so far. The
Externí odkaz:
https://doaj.org/article/a826cd1f56924ec59b2c5a34859e5f55
Autor:
Hadas Cohen-Dvashi, Jonathan Weinstein, Michael Katz, Maayan Eilon-Ashkenazy, Yuval Mor, Amir Shimon, Hagit Achdout, Hadas Tamir, Tomer Israely, Romano Strobelt, Maya Shemesh, Liat Stoler-Barak, Ziv Shulman, Nir Paran, Sarel Jacob Fleishman, Ron Diskin
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105193- (2022)
Summary: Blocking the interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with its angiotensin-converting enzyme 2 (ACE2) receptor was proved to be an effective therapeutic option. Various protein binders as well as monoclonal
Externí odkaz:
https://doaj.org/article/e87dd9a7a8014434a4badbb0f0c29d37
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110778- (2022)
Summary: Antibody-mediated immunity is initiated by B cell differentiation into multiple cell subsets, including plasmablast, memory, and germinal center (GC) cells. B cell differentiation trajectories are determined by transcription factors, yet ver
Externí odkaz:
https://doaj.org/article/9fa46b5cfee64e97ac60ed32bfee3c0f
Autor:
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increas
Externí odkaz:
https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Activation and differentiation of B cells depend on extensive rewiring of gene expression networks through changes in chromatin structure and accessibility. The chromatin remodeling complex BAF with its catalytic subunit Brg1 was previously identifie
Externí odkaz:
https://doaj.org/article/6947886a2c22468492650a7ef10fd0a6
Autor:
Rathan Joy Komban, Anneli Strömberg, Adi Biram, Jakob Cervin, Cristina Lebrero-Fernández, Neil Mabbott, Ulf Yrlid, Ziv Shulman, Mats Bemark, Nils Lycke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the
Externí odkaz:
https://doaj.org/article/dfa3b986a6dc4e698df2c098d4517404
Publikováno v:
Cell Adhesion & Migration, Vol 13, Iss 1, Pp 314-320 (2019)
It is unclear if naïve T cells require dendritic cell ICAMs to proliferate inside lymph nodes. To check if and when CD4 lymphocytes use ICAMs on migratory DCs, wild-type and ICAM-1 and 2 double knock out bone marrow-derived DCs pulsed with saturatin
Externí odkaz:
https://doaj.org/article/5cc387acedf745ec8c71bb10581837c8
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
Autor:
Rambabu N. Reddi, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, Roni Oren, Keren David, Jingjing Liu, Shirly Duberstein, Maxim Itkin, Sergey Malitsky, Haim Barr, Ben-Zion Katz, Yair Herishanu, Idit Shachar, Ziv Shulman, Nir London
Publikováno v:
Journal of the American Chemical Society. 145:3346-3360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f436a11b4b6322b7627191f360644f7
https://doi.org/10.1021/jacs.2c08853
https://doi.org/10.1021/jacs.2c08853