Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model.

Autor: Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H J Ramadan, Balazs Sumegi, Ferenc Gallyas

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239088 (2020)

Previously, we demonstrated the in vitro anti-tumor effects of desethylamiodarone (DEA) in bladder and cervix cancer cell lines. In the present study, we intended to establish its potentiality in B16-F10 metastatic melanoma cells in vitro and in vivo

Externí odkaz: https://doaj.org/article/a64999175cf34a90983eed523ede145f

Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.

Autor: Izabella Solti, Krisztian Kvell, Gergely Talaber, Sara Veto, Peter Acs, Ferenc Gallyas, Zsolt Illes, Katalin Fekete, Petra Zalan, Arpad Szanto, Zita Bognar

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129217 (2015)

Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions. Peripheral T-cell function in the cuprizone model has already been explored; therefore, in

Externí odkaz: https://doaj.org/article/cdf0c09afbda4a2f891df94e32f4ac79

Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line

Autor: Ferenc Gallyas, Fadi H. J. Ramadan, Kitti Andreidesz, Eniko Hocsak, Aliz Szabo, Antal Tapodi, Gyongyi N. Kiss, Katalin Fekete, Rita Bognar, Arpad Szanto, Zita Bognar

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1544, p 1544 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1544

Novel compounds significantly interfering with the mitochondrial energy production may have therapeutic value in triple-negative breast cancer (TNBC). This criterion is clearly fulfilled by desethylamiodarone (DEA), which is a major metabolite of ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5649ba2cf3d34044b1116cc8657bd4d0
https://pubmed.ncbi.nlm.nih.gov/35163464

Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model

Autor: Katalin Fekete, Zita Bognar, Csenge Antus, Ferenc Gallyas, Balazs Sumegi, Rita Bognar, Fadi H. J. Ramadan, Anna Mária Cseh, Antal Tapodi

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239088 (2020)

Previously, we demonstrated the in vitro anti-tumor effects of desethylamiodarone (DEA) in bladder and cervix cancer cell lines. In the present study, we intended to establish its potentiality in B16-F10 metastatic melanoma cells in vitro and in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8f7588b546635805cbb1f8c7421784
https://pubmed.ncbi.nlm.nih.gov/32977329

A multi-factor model developed on residents’ opinions for the classification of urban residential areas

Autor: Szabolcs Czigány, András Trócsányi, Zita Bognar, Péter Gyenizse, Gábor Pirisi

Publikováno v: Geografie. 121:1-31

The process of social differentiation in post-communist states has had a clear impact on the status of neighbourhoods. Municipalities have tried to handle the problem, but planning in Hungary is still based on shallow analyses. This paper presents a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54cb2b1edf81b1d10c516eac9d58c75b
https://doi.org/10.37040/geografie2016121010001