Comparison of Mitochondrial and Antineoplastic Effects of Amiodarone and Desethylamiodarone in MDA-MB-231 Cancer Line

Autor: Fadi H. J. Ramadan, Balazs Koszegi, Viola B. Vantus, Katalin Fekete, Gyongyi N. Kiss, Balint Rizsanyi, Rita Bognar, Ferenc Gallyas, Zita Bognar

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 18, p 9781 (2024)

Previously, we have demonstrated that amiodarone (AM), a widely used antiarrhythmic drug, and its major metabolite desethylamiodarone (DEA) both affect several mitochondrial processes in isolated heart and liver mitochondria. Also, we have establishe

Externí odkaz: https://doaj.org/article/b2f856ffd2d2410190010eba434aa696

Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model.

Autor: Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H J Ramadan, Balazs Sumegi, Ferenc Gallyas

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239088 (2020)

Previously, we demonstrated the in vitro anti-tumor effects of desethylamiodarone (DEA) in bladder and cervix cancer cell lines. In the present study, we intended to establish its potentiality in B16-F10 metastatic melanoma cells in vitro and in vivo

Externí odkaz: https://doaj.org/article/a64999175cf34a90983eed523ede145f

Cytostatic Effect of a Novel Mitochondria-Targeted Pyrroline Nitroxide in Human Breast Cancer Lines

Autor: Kitti Andreidesz, Aliz Szabo, Dominika Kovacs, Balazs Koszegi, Viola Bagone Vantus, Eszter Vamos, Mostafa Isbera, Tamas Kalai, Zita Bognar, Krisztina Kovacs, Ferenc Gallyas

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 16, p 9016 (2021)

Mitochondria have emerged as a prospective target to overcome drug resistance that limits triple-negative breast cancer therapy. A novel mitochondria-targeted compound, HO-5114, demonstrated higher cytotoxicity against human breast cancer lines than

Externí odkaz: https://doaj.org/article/ce7ba44a176e4e63bbf762d5f52e703c

Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways.

Autor: Zita Bognar, Katalin Fekete, Csenge Antus, Eniko Hocsak, Rita Bognar, Antal Tapodi, Arpad Boronkai, Nelli Farkas, Ferenc Gallyas, Balazs Sumegi, Arpad Szanto

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0189470 (2017)

Bladder cancer (BC) is a common malignancy of the urinary tract that has a higher frequency in men than in women. Cytostatic resistance and metastasis formation are significant risk factors in BC therapy; therefore, there is great interest in overcom

Externí odkaz: https://doaj.org/article/74750f6580ab4c3c8bb54a9d9565acb2

Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line

Autor: Ferenc Gallyas, Fadi H. J. Ramadan, Kitti Andreidesz, Eniko Hocsak, Aliz Szabo, Antal Tapodi, Gyongyi N. Kiss, Katalin Fekete, Rita Bognar, Arpad Szanto, Zita Bognar

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1544, p 1544 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1544

Novel compounds significantly interfering with the mitochondrial energy production may have therapeutic value in triple-negative breast cancer (TNBC). This criterion is clearly fulfilled by desethylamiodarone (DEA), which is a major metabolite of ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5649ba2cf3d34044b1116cc8657bd4d0
https://pubmed.ncbi.nlm.nih.gov/35163464