Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Zissis C, Chroneos"'
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1309 (2024)
Bronchopulmonary dysplasia (BPD) is a condition of poor alveolar formation that causes chronic breathing impairment in infants born prematurely. Preterm lungs lack surfactant and are vulnerable to oxidative injuries driving the development of BPD. Ou
Externí odkaz:
https://doaj.org/article/7c1978b28bc849768fca8cef91da6e2d
Autor:
Anthony S. Bonavia, Abigail Samuelsen, Menglu Liang, Jodi Hanson, Daniel McKeone, Zissis C. Chroneos, E. Scott Halstead
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods that rapidly and sensitively profile these immune responses can potentially personalize immune-adjuvant thera
Externí odkaz:
https://doaj.org/article/6b7f80b19ab24f1fbce8e70d047f84d9
Autor:
Eric Yau, Linlin Yang, Yan Chen, Todd M. Umstead, Hannah Atkins, Zoe E. Katz, Jonathan W. Yewdell, Chintan K. Gandhi, E. Scott Halstead, Zissis C. Chroneos
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Influenza A virus infection (IAV) often leads to acute lung injury that impairs breathing and can lead to death, with disproportionate mortality in children and the elderly. Surfactant Protein A (SP-A) is a calcium-dependent opsonin that binds a vari
Externí odkaz:
https://doaj.org/article/ee1c29f7544b428881aed0e21bc94850
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCell-based functional immune-assays may allow for risk stratification of patients with complex, heterogeneous immune disorders such as sepsis. Given the heterogeneity of patient responses and the uncertain immune pathogenesis of sepsis, the
Externí odkaz:
https://doaj.org/article/ba30b5d178c94c90ac056341ad81a384
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Introduction Because of the strong correlation between the blood concentration of circulating resistin and the illness severity of septic patients, resistin has been proposed as a mediator of sepsis pathophysiology. In vitro data indicate that human
Externí odkaz:
https://doaj.org/article/cd99ae7c8ca94792ab61b6a013681513
Autor:
Nikolaos Tsotakos, Imtiaz Ahmed, Todd M Umstead, Yuka Imamura, Eric Yau, Patricia Silveyra, Zissis C Chroneos
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272769 (2022)
IntroductionDespite recent advances in perinatal medicine, bronchopulmonary dysplasia (BPD) remains the most common complication of preterm birth. Inflammation, the main cause for BPD, results in arrested alveolarization. All trans-retinoic acid (ATR
Externí odkaz:
https://doaj.org/article/e0dc293142ae492a82cc89fd1be1150a
Autor:
Lauren Miller, Kai Singbartl, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang, Anthony Bonavia
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Sepsis-induced immunosuppression is a key factor contributing to the morbidity and mortality of critically ill patients, and polymorphonuclear neutrophil dysfunction is believed to be a hallmark of this immunosuppression. Circulat
Externí odkaz:
https://doaj.org/article/0f13818e2bf14702af1af69ad6800ead
Autor:
E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage, Zissis C. Chroneos
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from pathogenic influenza i
Externí odkaz:
https://doaj.org/article/02b87ee4fa9e4f2b8a3976e638c9ec51
Autor:
Kristin K. Fino, Linlin Yang, Patricia Silveyra, Sanmei Hu, Todd M. Umstead, Susan DiAngelo, E. Scott Halstead, Timothy K. Cooper, Thomas Abraham, Yoshinori Takahashi, Zhixiang Zhou, Hong Gang Wang, Zissis C. Chroneos
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract New influenza A viruses that emerge frequently elicit composite inflammatory responses to both infection and structural damage of alveolar-capillary barrier cells that hinders regeneration of respiratory function. The host factors that relin
Externí odkaz:
https://doaj.org/article/9f2db467b2f24fcdb539803d205c307c
Autor:
Armen Nalian, Todd M. Umstead, Ching-Hui Yang, Patricia Silveyra, Neal J. Thomas, Joanna Floros, Francis X. McCormack, Zissis C. Chroneos
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs), and epithelial cells. Non-primates express one SP-A protein whereas h
Externí odkaz:
https://doaj.org/article/dfef1749e33a476898eb6f07da97fd9c