Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing

Autor: Neroutsos E, Nalda-Molina R, Paisiou A, Zisaki K, Goussetis E, Spyridonidis A, Kitra V, Grafakos S, Valsami G, Dokoumetzidis A

Publikováno v: Pharmaceutics
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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We develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various sampling schedules on the calculation of AUC. Seventy-six children had 2 h infusions every

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::fa262b2fa55ae2ba57f8e76725118953
https://www.mdpi.com/1999-4923/14/3/647

Dose individualization of intravenous busulfan in pediatric patients undergoing bone marrow transplantation: Impact and in vitro evaluation of infusion lag-time

Autor: Neroutsos, E. Athanasiadou, I. Paisiou, A. Zisaki, K. Goussetis, E. Archontaki, H. Tsirigotis, P. Kitra, M. Grafakos, S. Spyridonidis, A. Dokoumetzidis, A. Valsami, G.

Objectives: To apply therapeutic drug monitoring and dose-individualization of intravenous Busulfan to paediatric patients and evaluate the impact of syringe-pump induced Busulfan infusion lag-time after in vitro estimation. Methods: 76 children and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::69bd5a7c81b6094ac3b73b5e89ca42cf
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020190

Infectious complications following allogeneic stem cell transplantation by using anti-thymocyte globulin-based myeloablative conditioning regimens in children with hemoglobinopathies

Autor: Goussetis, E. Efstathiou, E. Paisiou, A. Avgerinou, G. Zisaki, K. Giamouris, V.J. Peristeri, I. Kitra, V. Vessalas, G. Gamaletsou, M.N. Sipsas, N.V. Graphakos, S.

Background: Anti-thymocyte globulin (ATG) has been used to prevent graft failure/rejection in the setting of allogeneic stem cell transplantation (allo-SCT) for hemoglobinopathies; however, epidemiology data for transplant-related infections in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::8bf5aec705e9baa810990e520d979733
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3125234

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Evidence of improved serum fatty acid profile of postmenopausal women receiving atorvastatin and raloxifene

Autor: Piperi, C. Zisaki, K. Skenderi, K. Kalofoutis, C. Kalofoutis, A.

Raloxifene and atorvastatin have been shown to reduce the risk of cardiovascular disease associated with postmenopausal status and it has been postulated that their effects may be partly mediated by favourable changes in serum lipids and fatty acid c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::1669b5e0a2a8062e23fd647e407ed7f6
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3134620