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Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A -L1342P mutation.

Autor: Que Z; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Olivero-Acosta MI; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Robinson M; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907.; Department of Chemical Engineering, Purdue University, West Lafayette, IN 47907., Chen I; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Zhang J; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Wettschurack K; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Wu J; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Xiao T; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Otterbacher CM; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Shankar V; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Harlow H; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Hong S; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Zirkle B; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Wang M; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Cui N; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Mandal P; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Chen X; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Deming B; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Halurkar M; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Zhao Y; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Rochet JC; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907., Xu R; Purdue University College of Veterinary Medicine, West Lafayette, IN 47907., Brewster AL; Department of Biological Sciences, Southern Methodist University, Dallas TX 75205., Wu LJ; Department of Neurology at Mayo Clinic, Rochester MN 55905., Yuan C; Department of Chemical Engineering, Purdue University, West Lafayette, IN 47907., Skarnes WC; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032., Yang Y; Borsch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.; Purdue Institute for Integrative Neuroscience (PIIN), Purdue University, West Lafayette, IN 47907.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.