Výsledky vyhledávání - "Ziqiao, Chen"

Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids

Autor: Ziqiao Chen, Kenjirou Higashi, Yuki Shigehisa, Keisuke Ueda, Keiji Yamamoto, Kunikazu Moribe

Publikováno v: Nanoscale.

We previously established a nanoparticle-based drug delivery system (DDS) for high-dose ascorbic acid therapy by self-assembly of a lipid-modified ascorbic acid derivative, L-ascorbyl 2,6-dipalmitate (ASC-DP). The particles' morphology should be modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2108852acd48f5d302963423cd26e20
https://pubmed.ncbi.nlm.nih.gov/36484313

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Multistep Crystallization of Pharmaceutical Amorphous Nanoparticles via a Cognate Pathway of Oriented Attachment: Direct Evidence of Nonclassical Crystallization for Organic Molecules

Autor: Ziqiao Chen, Kenjirou Higashi, Keisuke Ueda, Kunikazu Moribe

Publikováno v: Nano letters. 22(16)

Crystallization of organic molecules is important in a wide range of scientific disciplines. However, in contrast to maturely studied crystallization of inorganic materials, the crystallization mechanisms of organic molecules involving nucleation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e072a86cc93c44cb0fb3989777793a8c
https://pubmed.ncbi.nlm.nih.gov/35830610

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Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency

Autor: Tomonari Sumi, Sayaka Mukaide, Hiroshi Imamura, Kunikazu Moribe, Kenjirou Higashi, Ziqiao Chen, Takeshi Morita

Publikováno v: Nano Letters. 21:1303-1310

Polymeric micelles are invaluable media as drug nanocarriers. Although knowledge of an interaction between the micelles is a key to understanding the mechanisms and developing the superior functions, the interaction potential surface between drug-inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e1d0631f603e0d767ed38cd828add6
https://doi.org/10.1021/acs.nanolett.0c03978

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Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution

Autor: Kenjirou Higashi, Keisuke Ueda, Ziqiao Chen, Kunikazu Moribe

Publikováno v: Molecular pharmaceutics. 19(1)

Amorphous drug nanoparticles usually exhibit low storage stability. A comprehensive understanding of the molecular states and physicochemical properties of the product is indispensable for designing stable formulations. In the present study, an amorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa91b41378f3e6c04ff5f06dbd90f14
https://pubmed.ncbi.nlm.nih.gov/34843257

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Effect of molecular weight of hypromellose on mucin diffusion and oral absorption behavior of fenofibrate nanocrystal

Autor: Keisuke Ueda, Kenjirou Higashi, Ziqiao Chen, Takaaki Iwai, Kunikazu Moribe, Yushi Sunazuka, Nao Kato

Publikováno v: International Journal of Pharmaceutics. 564:39-47

We investigated the effect of variation in the molecular weight of hypromellose (HPMC) on the oral absorption of fenofibrate (FFB) nanocrystal. Four types of HPMC with different molecular weights and sodium dodecyl sulfate (SDS) were used as dispersi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f06b0f47f1eb2007880f2e4448d7ba8
https://doi.org/10.1016/j.ijpharm.2019.04.033

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The nanostructure of rod-like ascorbyl dipalmitate nanoparticles stabilized by a small amount of DSPE-PEG

Autor: Waree Limwikrant, Ziqiao Chen, Takeshi Morita, Kunikazu Moribe, Keisuke Ueda, Ryuhei Shidara, Keiji Yamamoto, Kenjirou Higashi

Publikováno v: International journal of pharmaceutics. 602

Previously, we reported the formation of 100–200 nm disk- and tube-like nanoparticles by hydration of L-ascorbyl 2,6-dipalmitate (ASC-DP) and distearoylphosphatidylethanolamine polyethylene glycol 2000 (DSPE-PEG) films prepared at an initial molar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cf93664296243f5045a806d743d9d8
https://pubmed.ncbi.nlm.nih.gov/33862127

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Akademický článek

The Employment Impact of a Green Fiscal Push: Evidence from the American Recovery and Reinvestment Act.

Autor: POPP, DAVID, VONA, FRANCESCO, MARIN, GIOVANNI, ZIQIAO CHEN

Publikováno v: Brookings Papers on Economic Activity; Fall2021, p1-49, 49p

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