Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Zippora Shakked"'
Autor:
Oksana Degtjarik, Dmitrij Golovenko, Yael Diskin-Posner, Lars Abrahmsén, Haim Rozenberg, Zippora Shakked
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The tumor suppressor p53 is mutated in more than half of human cancers and the compound methylene quinuclidinone (MQ) was shown to reactivate p53 mutants by binding covalently to cysteine residues. Here, the authors present crystal structures of wild
Externí odkaz:
https://doaj.org/article/61ab66026ad342f6901e1b078e2ffc95
Autor:
Nadav Elad, Szilvia Baron, Yoav Peleg, Shira Albeck, Jacob Grunwald, Gal Raviv, Zippora Shakked, Oren Zimhony, Ron Diskin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
The type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cry
Externí odkaz:
https://doaj.org/article/11b0d9221adb4b1bbbacb74016a4bfa6
Autor:
Szilvia Baron, Yoav Peleg, Jacob Grunwald, David Morgenstern, Nadav Elad, Moshe Peretz, Shira Albeck, Yishai Levin, John T Welch, Kim A DeWeerd, Alon Schwarz, Yigal Burstein, Ron Diskin, Zippora Shakked, Oren Zimhony
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204457 (2018)
BACKGROUND:Fatty acid synthase 1 (FAS I) from Mycobacterium tuberculosis (Mtb) is an essential protein and a promising drug target. FAS I is a multi-functional, multi-domain protein that is organized as a large (1.9 MDa) homohexameric complex. Acyl i
Externí odkaz:
https://doaj.org/article/1d9f222d744f434093bda218d542647c
Autor:
Zippora Shakked, Itai Beno, Zhiqun Xi, Naama Kessler, Tali E. Haran, Varda Rotter, Dmitrij Golovenko, Pratik Vyas, Yan Stein
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10624-10629
The tumor suppressor protein p53 acts as a transcription factor, binding sequence-specifically to defined DNA sites, thereby activating the expression of genes leading to diverse cellular outcomes. Canonical p53 response elements (REs) are made of tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6e8cc78cffee4a1a3e873fdf75db61
https://doi.org/10.1073/pnas.1618005114
https://doi.org/10.1073/pnas.1618005114
Autor:
Zippora Shakked, Dmitrij Golovenko, Oksana Degtjarik, Lars Abrahmsén, Yael Diskin-Posner, Haim Rozenberg
Publikováno v:
'Nature Communications ', vol: 12, pages: 7057-1-7057-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
In response to genotoxic stress, the tumor suppressor p53 acts as a transcription factor by regulating the expression of genes critical for cancer prevention. Mutations in the gene encoding p53 are associated with cancer development. PRIMA-1 and epre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa2f84eb5ba41fb3a40825e58a5fcf8
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59048
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59048
Autor:
Zippora Shakked, Moshe Peretz, Nadav Elad, Ron Diskin, John T. Welch, Shira Albeck, Yoav Peleg, Yigal Burstein, Kim A. DeWeerd, Jacob Grunwald, Oren Zimhony, Alon Schwartz, Yishai Levin, Szilvia Baron, David Morgenstern
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0204457 (2018)
PLoS ONE, Vol 13, Iss 9, p e0204457 (2018)
Fatty acid synthase 1 (FAS I) from Mycobacterium. tuberculosis (Mtb) is an essential protein and a promising drug target. FAS I is a multi-functional, multi-domain protein that is organized as a large (1.9 MDa) homohexameric complex. Acyl intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154a90edf6c694616815c90f0ccafcd1
https://doi.org/10.1101/400622
https://doi.org/10.1101/400622
Autor:
Dmitrij Golovenko, Haim Rozenberg, Zippora Shakked, Tali E. Haran, Bastian Bräuning, Pratik Vyas
Publikováno v:
Structure (London, England : 1993). 26(9)
The tumor suppressor p53 acts as a transcription factor recognizing diverse DNA response elements (REs). Previous structural studies of p53-DNA complexes revealed non-canonical Hoogsteen geometry of A/T base pairs at conserved CATG motifs leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11717aba7e928d999f30d65bb46f40
https://pubmed.ncbi.nlm.nih.gov/30184478
https://pubmed.ncbi.nlm.nih.gov/30184478
Autor:
Szilvia Baron, Gal Raviv, Yoav Peleg, Shira Albeck, Zippora Shakked, Jacob Grunwald, Nadav Elad, Oren Zimhony, Ron Diskin
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Tuberculosis (TB) is a devastating and rapidly spreading disease caused by Mycobacterium tuberculosis (Mtb). Therapy requires prolonged treatment with a combination of multiple agents and interruptions in the treatment regimen result in emergence and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0729dcf3e3d263d39198f18e0281269d
Publikováno v:
Nucleic Acids Research
'Nucleic Acids Research ', vol: 41, pages: 8748-8759 (2013)
'Nucleic Acids Research ', vol: 41, pages: 8748-8759 (2013)
A p53 hot-spot mutation found frequently in human cancer is the replacement of R273 by histidine or cysteine residues resulting in p53 loss of function as a tumor suppressor. These mutants can be reactivated by the incorporation of second-site suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833f9d6b083a02b01c093486beb53006
https://doi.org/10.1093/nar/gkt630
https://doi.org/10.1093/nar/gkt630
Autor:
Zippora Shakked, Remo Rohs, Malka Kitayner, Dov Rabinovich, Barry Honig, Haim Rozenberg, Oded Suad
Publikováno v:
Nature Structural & Molecular Biology. 17:423-429
p53 binds as a tetramer to DNA targets consisting of two decameric half-sites separated by a variable spacer. Here we present high-resolution crystal structures of complexes between p53 core-domain tetramers and DNA targets consisting of contiguous h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84792dac89fbaaf7da4d5cd4cddefd98
https://doi.org/10.1038/nsmb.1800
https://doi.org/10.1038/nsmb.1800