Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Zipora Speiser"'
Publikováno v:
Journal of Neural Transmission. 115:107-116
This study investigated whether rasagiline and selegiline (MAO-B inhibitors) induce serotonin syndrome in fluoxetine-treated rats. Rats received rasagiline (0.1, 0.5, 2.0 mg/kg), or selegiline (0.8, 4.0, 16.0 mg/kg) (doses reflecting the clinical rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00276ebee135aa6d3cf7b48aed75ea41
https://doi.org/10.1007/s00702-007-0811-8
https://doi.org/10.1007/s00702-007-0811-8
Publikováno v:
Journal of Neural Transmission. 114:595-605
The neuroprotective effects of intravenous rasagiline were investigated in a rat model of stroke. Middle cerebral artery (MCA) occlusion was performed in male rats and the short- (neurological severity score [NSS], infarct size), intermediate- (cogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cc6280428d1435857196047add925d
https://doi.org/10.1007/s00702-006-0612-5
https://doi.org/10.1007/s00702-006-0612-5
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 319:332-339
Perinatal hypoxic injury is associated with significant neonatal morbidity and long-term neurodevelopmental complications. NAP, a peptide derived from ADNP (activity-dependent neuroprotective protein), has previously shown neuroprotective abilities i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972761847fb40581ec551e5bb7e75e14
https://doi.org/10.1124/jpet.106.106898
https://doi.org/10.1124/jpet.106.106898
Publikováno v:
Experimental Neurology. 184:726-736
Hypertension is one of the major risk factors of stroke and vascular dementia (VaD). We used stroke prone spontaneous hypertensive rats (SPSHRs) as a model for neuronal degeneration frequently occurring in humans with vascular disease. Recently, high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681838148fcbcded985b5eddfe3d049d
https://doi.org/10.1016/s0014-4886(03)00274-7
https://doi.org/10.1016/s0014-4886(03)00274-7
Publikováno v:
Journal of Neural Transmission. 106:593-606
Rasagiline, as the mesylate salt (TVP-1012), is a selective, potent, non-reversible MAO-B inhibitor of the propargylamine type. Current cellular and whole animal studies suggested a potential for neuroprotection by rasagiline. Rasagiline in repeat ip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b06beab0d2f651d2be7b49514f6d531
https://doi.org/10.1007/s007020050182
https://doi.org/10.1007/s007020050182
Publikováno v:
Pharmacology Biochemistry and Behavior. 60:387-393
Rasagiline (N-propargyl-1(R)aminoindan) is a selective and potent MAO-B inhibitor currently under development as the mesylate salt (TVP-1012) for the treatment of various neurologic disorders. Preliminary work in adult and senescent rats, either norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625d8949055550100c592bac44385fe3
https://doi.org/10.1016/s0091-3057(97)00603-5
https://doi.org/10.1016/s0091-3057(97)00603-5
Publikováno v:
European Journal of Pharmacology. 195:75-83
Increased motor activity and poor performance in the active avoidance test were observed in the offspring of rats treated with d1-propranolol or sotalol during pregnancy, but not with atenolol and d-propranolol. All substances were administered in dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0a2f4f88f18e710c566ddd6daa7b4c
https://doi.org/10.1016/0014-2999(91)90383-2
https://doi.org/10.1016/0014-2999(91)90383-2
Autor:
Paul H. Gordon, Caterina Bendotti, Jacqueline Montes, Sari Goren, Zipora Speiser, Cristina Cheroni, Eran Blaugrund, Massimo Tortarolo, Hussein Hallak
Publisher Summary Amyotrophic Lateral Sclerosis (ALS) is an age-related neurodegenerative disease affecting Motor Neurons (MNs). There is no known cure and survival extends approximately 3 years on average from symptom onset. Nearly two decades ago,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e228da26da10389ef45c4ea744aa8eaf
https://doi.org/10.1016/b978-0-12-373861-5.00019-9
https://doi.org/10.1016/b978-0-12-373861-5.00019-9
Publikováno v:
Behavioural Brain Research. 37:19-27
Wistar male rats, 3-4 months old, were made to breathe for 6 h a sub-lethal hypoxic atmosphere consisting of 8% oxygen and 92% nitrogen. Following this treatment, these rats were subjected to a series of behavioral and biochemical tests starting 30 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf36c4bf1b6d9622ce642c65e32d060
https://doi.org/10.1016/0166-4328(90)90068-p
https://doi.org/10.1016/0166-4328(90)90068-p
Publikováno v:
Journal of neural transmission (Vienna, Austria : 1996). 108(8-9)
The aim of this study was to determine whether chronic treatment with the selective MAO-B inhibitor rasagiline, N-propargyl-1-(R)-aminoindan (R-PAI), can prevent or delay stroke or improve its outcome in salt-loaded stroke-prone spontaneously hyperte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf19df70714eea71b18006820f6ca3dc
https://pubmed.ncbi.nlm.nih.gov/11716145
https://pubmed.ncbi.nlm.nih.gov/11716145