Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Zipora Pittel"'
Publikováno v:
NeuroToxicology. 66:121-127
This work focused on sex differences in rats exposed to sarin. Females were found to be more sensitive to sarin toxicity (LD50 67 μg/kg) than males (88 μg/kg), showed less acute hypothermic effects than males (at 120 min post sarin, 3.1 ± 1.1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618d6f59686641ad5ab89aa425ebc69d
https://doi.org/10.1016/j.neuro.2018.04.002
https://doi.org/10.1016/j.neuro.2018.04.002
Publikováno v:
NeuroToxicology. 65:248-254
The effect of sarin on the binding parameters (KD & Bmax) of M2 muscarinic acetylcholine receptor (mAChR) was studied 24h and 1 week post exposure. Male & female Sprague-Daweley rats were poisoned with 1XLD50 sarin (80μg/kg, im) followed by treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62097ccff04d0f5a395d750e3db99268
https://doi.org/10.1016/j.neuro.2017.11.002
https://doi.org/10.1016/j.neuro.2017.11.002
Autor:
Shmuel Mandel, Eliezer Giladi, Douglas E. Brenneman, Andrew M. Goldsweig, Stephen J. Servoss, Zipora Pittel, Illana Gozes, Albert Pinhasov, Arkady Torchinsky
Publikováno v:
Developmental Brain Research. 144:83-90
We have recently cloned the novel homeobox-containing activity-dependent neuroprotective protein (ADNP). In the current study, mouse ADNP was shown to be expressed at the time of neural tube closure, detected at E7.5 and increased on E9.5. Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f324bbe759676a5206140b414779bc81
https://doi.org/10.1016/s0165-3806(03)00162-7
https://doi.org/10.1016/s0165-3806(03)00162-7
Autor:
Niva Natan, Nira Bar-Ner, Itzhak Marcovitch, Hagar Sonego, Rachel Brandeis, Abraham Fisher, Zipora Pittel, Rachel Haring, Inbal Egozi, Michal Kliger-Spatz
Publikováno v:
Journal of Molecular Neuroscience. 20:349-356
M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer's disease (AD): beta-amyloid (Abeta) peptide; tau hyperphosphorylation and paired helical filaments (PHFs); and loss of cholinergic function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e248057e74a82b0a89fd32b3494b06f1
https://doi.org/10.1385/jmn:20:3:349
https://doi.org/10.1385/jmn:20:3:349
Autor:
Niva Natan, Itzhak Marcovitch, Rachel Haring Nira Bar-Ner, Hagar Sonego, Michal Kliger-Spatz, Abraham Fisher, Rachel Brandeis, Zipora Pittel
Publikováno v:
Journal of Molecular Neuroscience. 19:145-153
The M1 muscarinic agonists AF102B (Cevimeline, EVOXACTM: prescribed in USA and Japan for Sjogren's Syndrome), AF150(S) and AF267B--1) are neurotrophic and synergistic with neurotrophins such as nerve growth factor and epidermal growth factor; 2) elev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c7c29934d68f9757c6099a183d5139
https://doi.org/10.1007/s12031-002-0025-3
https://doi.org/10.1007/s12031-002-0025-3
Autor:
Orli Eisenberg, Yishai Karton, Daniele Marciano, Rachel Haring, Abraham Fisher, Zipora Pittel, Rachel Brandeis, Haim Meshulam, Eliahu Heldman, Nira Bar-Ner, Naomi Eshhar
Publikováno v:
Journal of Physiology-Paris. 92:337-340
M1 selective agonists from the AF series (e.g. AF102B, AF150(S)), via m1 muscarinic receptors, activate distinct signal transductions, enhance amyloid precursors proteins secretion from transfected cells and primary cell cultures, show neurotrophic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971914d532748def2f93a2dc9ef5d28e
https://doi.org/10.1016/s0928-4257(99)80001-1
https://doi.org/10.1016/s0928-4257(99)80001-1
Publikováno v:
Brain Research. 742:299-304
It was previously shown by us and by others that activation of muscarinic acetylcholine receptors evoke amyloid precursor protein (APP) secretion in various cell lines. Here we examined if such muscarinic control of APP secretion occurs also in norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b627c999c1c02119bc041c83f6b17e
https://doi.org/10.1016/s0006-8993(96)01031-1
https://doi.org/10.1016/s0006-8993(96)01031-1
Autor:
Jacob Barg, Eliahu Heldman, Zvi Vogel, Rivka Levy, Moshe Kushnir, Abraham Fisher, Zipora Pittel, Reuven Zimlichman
Publikováno v:
European Journal of Pharmacology. 297:283-291
Muscarinic receptor agonists activate phosphoinositide hydrolysis and adenylate cyclase in Chinese hamster ovary cells transfected with cDNAs encoding the human muscarinic ml and m3 receptors. Whereas carbachol activates similarly both receptor subty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869754bed2aaee8d2b8777bd72c6f69a
https://doi.org/10.1016/0014-2999(95)00745-8
https://doi.org/10.1016/0014-2999(95)00745-8
Autor:
Abraham Fisher, Yishai Karton, Zvi Vogel, Zipora Pittel, David Gurwitz, Rachel Brandeis, Rachel Haring, Menahem Segal, Dov Barak, Eliahu Heldman, Haim Meshulam, Daniele Marciano
Publikováno v:
Annals of the New York Academy of Sciences. 695:300-303
Rigid analogs of acetylcholine (ACh) were designed for selective actions at muscarinic receptor (mAChR) subtypes and distinct second messenger systems. AF102B, AF150, and AF151 are such rigid analogs of ACh. AF102B, AF150 and AF151 are centrally acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0301b68bfffd096ced1f2ead1690ecf3
https://doi.org/10.1111/j.1749-6632.1993.tb23070.x
https://doi.org/10.1111/j.1749-6632.1993.tb23070.x
Autor:
Rachel Haring, Daniele Marciano, Eliahu Heldman, David Gurwitz, Haim Meshulam, Rachel Brandeis, Abraham Fisher, Dov Barak, Ishai Karton, Zipora Pittel, Zvi Vogel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:839-844
Rigid analogs of acetylcholine offer an opportunity for selective actions at muscarinic receptor subtypes, since restricted conformational mobility alters the capacity of ligands to adapt to subtle differences in receptor structure. AF102B , a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d02494e2795d848cb0c6fde76898d0
https://doi.org/10.1016/s0960-894x(00)80541-7
https://doi.org/10.1016/s0960-894x(00)80541-7