Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Zipfel, Sheila"'
Autor:
Cheng Y. Yang, Cottell Jeromy J, Krygowski Evan S, Jason K. Perry, Katana Ashley Anne, Mei Yu, Yujin Wang, Tran Chinh Viet, Guangyu Zhao, Yang Zheng-Yu, Kelly Wang, Yu-Jen Lee, Ruoyu Gong, Eric M. Gorman, Alejandra Trejo-Martin, Yang Tian, Kato Darryl, Erik Mogalian, Bacon Elizabeth M, Link John O, James G. Taylor, Guofeng Cheng, Zipfel Sheila
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2415-2427
Direct-acting antiviral inhibitors have revolutionized the treatment of hepatitis C virus (HCV) infected patients. Herein is described the discovery of velpatasvir (VEL, GS-5816), a potent pan-genotypic HCV NS5A inhibitor that is a component of the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e1fbe8045531556d55ed210cd6fe2a
https://doi.org/10.1016/j.bmcl.2019.04.027
https://doi.org/10.1016/j.bmcl.2019.04.027
Autor:
Kyla Ramey, Katana Ashley Anne, Kato Darryl, Tran Chinh Viet, Cheng Y. Yang, Link John O, Debi Jin, Yujin Wang, Kobayashi Tetsuya, Karki Kapil Kumar, Armando G. Villaseñor, Todd C. Appleby, Kelly Wang, Sangi Michael, Jeff Zablocki, Randy Vivian, Brian E. Schultz, Yang Zheng-Yu, Guofeng Cheng, Dustin Siegel, Zipfel Sheila, Ona Barauskas, James G. Taylor, Martinez Ruben, Katie Chan, Adam J. Schrier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2428-2436
Treatment of hepatitis C virus (HCV) infection has been historically challenging due the high viral genetic complexity wherein there are eight distinct genotypes and at least 86 viral subtypes. While HCV NS3/4A protease inhibitors are an established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210d14a9952795cbbb25c9ee4809cc66
https://doi.org/10.1016/j.bmcl.2019.03.037
https://doi.org/10.1016/j.bmcl.2019.03.037
Autor:
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 August 2019 29(16):2428-2436
Autor:
Link, John O., Taylor, James G., Trejo-Martin, Alejandra, Kato, Darryl, Katana, Ashley A., Krygowski, Evan S., Yang, Zheng-Yu, Zipfel, Sheila, Cottell, Jeromy J., Bacon, Elizabeth M., Tran, Chinh V., Yang, Cheng Y., Wang, Yujin, Wang, Kelly W., Zhao, Guangyu, Cheng, Guofeng, Tian, Yang, Gong, Ruoyu, Lee, Yu-Jen, Yu, Mei, Gorman, Eric, Mogalian, Erik, Perry, Jason K.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 August 2019 29(16):2415-2427
Autor:
Fabien Vincent, Michelle Dourado, Daniel Emerling, Luna Liu, Victor Yip, Margaret Nguyen, Zhi-Liang Wei, Zipfel Sheila, Candace Chi, Amy Gustafson, Jeff DeFalco, Michael G. Kelly, John Kincaid, Qingling Zhang, Donogh J R O'Mahony, Matthew A.J. Duncton, Alejandra Acevedo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4011-4015
Antagonists of the TRPV4 receptor were identified using a focused screen, followed by a limited optimization program. The leading compounds obtained from this exercise, RN-1665 23 and RN-9893 26, showed moderate oral bioavailability when dosed to rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53256b218e4196c4d5f87c151a03f04
https://doi.org/10.1016/j.bmcl.2015.06.098
https://doi.org/10.1016/j.bmcl.2015.06.098
Autor:
Wei, Zhi-Liang, Nguyen, Margaret T., O’Mahony, Donogh J.R., Acevedo, Alejandra, Zipfel, Sheila, Zhang, Qingling, Liu, Luna, Dourado, Michelle, Chi, Candace, Yip, Victor, DeFalco, Jeff, Gustafson, Amy, Emerling, Daniel E., Kelly, Michael G., Kincaid, John, Vincent, Fabien, Duncton, Matthew A.J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 September 2015 25(18):4011-4015
Autor:
Donogh J R O'Mahony, Matthew Cox, William T. Edwards, Matthew A.J. Duncton, Kiran P. Sahasrabudhe, Darlene Tan, Zipfel Sheila, M. Angels Estiarte
Publikováno v:
Journal of Heterocyclic Chemistry. 46:1125-1131
A one-step synthesis of thiazolo[5,4-b]pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazolo[5,4-b]pyridine derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd89f6f03902d5a13e340313e13f25c
https://doi.org/10.1002/jhet.185
https://doi.org/10.1002/jhet.185
Autor:
Matthew Duncton, William T. Edwards, Darlene Tan, Zipfel Sheila, Matthew Cox, Kiran Sahasrabudhe, M. Angels Estiarte, Donogh J. R. O'Mahony
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dce811a9dab9b830ecd8ae8d3f67deb
https://doi.org/10.1002/chin.201015155
https://doi.org/10.1002/chin.201015155
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Sahasrabudhe, Kiran P., Angels Estiarte, M., Tan, Darlene, Zipfel, Sheila, Cox, Matthew, OMahony, Donogh J. R., Edwards, William T., Duncton, Matthew A. J.
Publikováno v:
Journal of Heterocyclic Chemistry; November 2009, Vol. 46 Issue: 6 p1125-1131, 7p