Systemic Delivery of a Dual PI3K/mTOR Inhibitor More Effective than Topical Delivery in Preventing Anal Carcinogenesis in an HPV Transgenic Mouse Model.

Autor: Gunder LC; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA., Moyer TH; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Ziolkowski MR; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA., Keating MK; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Leverson GE; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA., Zhang W; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Carchman EH; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, UW Health University Hospital, Madison, Wisconsin, USA.

Publikováno v: Journal of cancer science and clinical therapeutics [J Cancer Sci Clin Ther] 2022; Vol. 6 (2), pp. 157-173. Date of Electronic Publication: 2022 Apr 18.