Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

Autor: Burchard, Esteban, Bunyavanich, S, Schadt, EE, Himes, BE, Lasky-Su, J, Qiu, W, Lazarus, R, Ziniti, JP, Cohain, A, Linderman, M, Torgerson, DG

Publikováno v: Burchard, Esteban; Bunyavanich, S; Schadt, EE; Himes, BE; Lasky-Su, J; Qiu, W; et al.(2014). Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6rh536w4

© 2014 Bunyavanich et al.; licensee BioMed Central Ltd.Background: Allergic rhinitis is a common disease whose genetic basis is incompletely explained. We report an integrated genomic analysis of allergic rhinitis. Methods. We performed genome wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::dd81ccde7c926bbe4b66519256a85531
http://www.escholarship.org/uc/item/6rh536w4

Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.

Autor: Moll M; Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass., Sordillo JE; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass., Ghosh AJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, SUNY Upstate Medical Center, Syracuse, NY., Hayden LP; Department of Pediatrics, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts General Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., McDermott G; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Mass., McGeachie MJ; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Dahlin A; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Tiwari A; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Manmadkar MG; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Abston ED; Department of Thoracic Surgery, Massachusetts General Hospital, Boston, Mass., Pavuluri C; Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass., Saferali A; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Begum S; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Ziniti JP; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Gulsvik A; Department of Clinical Science, University of Bergen, Bergen, Norway., Bakke PS; Department of Clinical Science, University of Bergen, Bergen, Norway., Aschard H; Department of Computational Biology, Institut Pasteur, Universit de Paris, Paris, France., Iribarren C; Division of Research, Kaiser Permanente Northern California, Oakland, Calif., Hersh CP; Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass., Sparks JA; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Mass., Hobbs BD; Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass., Lasky-Su JA; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Silverman EK; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Weiss ST; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Mass., Wu AC; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass., Cho MH; Department of Medicine, Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Mass; Harvard Medical School, Brigham and Women's Hospital, Boston, Mass. Electronic address: remol@channing.harvard.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Dec; Vol. 152 (6), pp. 1423-1432. Date of Electronic Publication: 2023 Aug 16.

Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation.

Autor: Croteau-Chonka DC; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Rogers AJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Division of Pulmonary and Critical Care Medicine, School of Medicine, Stanford University, Stanford, California, United States of America., Raj T; Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America., McGeachie MJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Qiu W; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Ziniti JP; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Stubbs BJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Liang L; Departments of Biostatistics and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America., Martinez FD; Arizona Respiratory Center and BIO5 Institute, University of Arizona, Tucson, Arizona, United States of America., Strunk RC; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Lemanske RF Jr; University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America., Liu AH; Division of Allergy and Clinical Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, United States of America., Stranger BE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America., Carey VJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Raby BA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; BWH Pulmonary Genetics Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

Publikováno v: PloS one [PLoS One] 2015 Oct 16; Vol. 10 (10), pp. e0140758. Date of Electronic Publication: 2015 Oct 16 (Print Publication: 2015).

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

Autor: Cho MH; Channing Laboratory, Brigham & Women’s Hospital, Boston, MA 02115, USA. michael.cho@channing.harvard.edu, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK

Publikováno v: Human molecular genetics [Hum Mol Genet] 2012 Feb 15; Vol. 21 (4), pp. 947-57. Date of Electronic Publication: 2011 Nov 11.

Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.

Autor: Wan ES; Channing Laboratory, Boston, Massachusetts, USA., Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL

Publikováno v: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2011 Aug; Vol. 45 (2), pp. 304-10. Date of Electronic Publication: 2010 Oct 29.