Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Zinia J Kwidama"'
Autor:
Costa Bachas, Gerrit Jan Schuurhuis, C Michel Zwaan, Marry M van den Heuvel-Eibrink, Monique L den Boer, Eveline S J M de Bont, Zinia J Kwidama, Dirk Reinhardt, Ursula Creutzig, Valérie de Haas, Gertjan J L Kaspers, Jacqueline Cloos
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121730 (2015)
Development of relapse remains a problem for further improvements in the survival of pediatric AML patients. While virtually all patients show a good response to initial treatment, more patients respond poorly when treated at relapse. The cellular ch
Externí odkaz:
https://doaj.org/article/f2c2fd5f271c447aa5b3df572240735c
Autor:
François G. Kavelaars, Elvira Verhoef, Bianca Venniker-Punt, Peter J. M. Valk, Christian M. Vonk, Pauline A. Merle, Zinia J. Kwidama, Jacqueline Cloos, Patrycja L Gradowska, Jeroen Janssen, David G. J. Cucchi, Bob Löwenberg, Melissa Rijken
Publikováno v:
Cucchi, D G, Vonk, C M, Rijken, M, Kavelaars, F, Merle, P, Verhoef, E, Venniker-Punt, B, Kwidama, Z J, Gradowska, P, Löwenberg, B, Janssen, J J W M, Cloos, J & Valk, P J M 2021, ' DNA vs cDNA FLT3-ITD allelic ratio and length measurements in adult acute myeloid leukemia ', BLOOD ADVANCES, vol. 5, no. 21, pp. 4476-4479 . https://doi.org/10.1182/bloodadvances.2021004980
Blood Advances
Blood advances, 5(21), 4476-4479. American Society of Hematology
BLOOD ADVANCES, 5(21), 4476-4479. American Society of Hematology
Blood Advances
Blood advances, 5(21), 4476-4479. American Society of Hematology
BLOOD ADVANCES, 5(21), 4476-4479. American Society of Hematology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b787f38dc96d2345cc2e518086b31a
https://research.vumc.nl/en/publications/0a7b0550-67cd-4a96-a66d-a7a25142ae3d
https://research.vumc.nl/en/publications/0a7b0550-67cd-4a96-a66d-a7a25142ae3d
Autor:
Gertjan J.L. Kaspers, Sonja Zweegman, Johan van Meerloo, Zinia J. Kwidama, Giovanna ter Huizen, Gerrit Jansen, Jacqueline Cloos, Margot S. F. Roeten, Wouter H. Segerink
Publikováno v:
Roeten, M S F, van Meerloo, J, Kwidama, Z J, ter Huizen, G, Segerink, W H, Zweegman, S, Kaspers, G J L, Jansen, G & Cloos, J 2021, ' Pre-Clinical Evaluation of the Proteasome Inhibitor Ixazomib against Bortezomib-Resistant Leukemia Cells and Primary Acute Leukemia Cells ', Cells, vol. 10, no. 3, 665, pp. 1-15 . https://doi.org/10.3390/cells10030665
Cells
Volume 10
Issue 3
Cells, 10(3):665, 1-15. MDPI Multidisciplinary Digital Publishing Institute
Cells, Vol 10, Iss 665, p 665 (2021)
Cells
Volume 10
Issue 3
Cells, 10(3):665, 1-15. MDPI Multidisciplinary Digital Publishing Institute
Cells, Vol 10, Iss 665, p 665 (2021)
At present, 20–30% of children with acute leukemia still relapse from current chemotherapy protocols, underscoring the unmet need for new treatment options, such as proteasome inhibition. Ixazomib (IXA) is an orally available proteasome inhibitor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b163b89de767ad688c208c8b46df8a
https://research.vumc.nl/en/publications/9792b04a-da28-4ed2-81d5-a33315fdef31
https://research.vumc.nl/en/publications/9792b04a-da28-4ed2-81d5-a33315fdef31
Autor:
Susan T.C.J.M. Arentsen-Peters, Yehuda G. Assaraf, Valerie de Haas, Jacqueline Cloos, David G. J. Cucchi, Gerrit Jan Schuurhuis, Costa Bachas, Marry M. van den Heuvel-Eibrink, Zinia J. Kwidama, Gertjan J.L. Kaspers
Publikováno v:
Cancers, 12(5). Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 12, Iss 1247, p 1247 (2020)
Cancers, 12(5):1247. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cucchi, D G J, Bachas, C, van den Heuvel-Eibrink, M M, Arentsen-Peters, S T C J M, Kwidama, Z J, Schuurhuis, G J, Assaraf, Y G, de Haas, V, Kaspers, G J L & Cloos, J 2020, ' Harnessing gene expression profiles for the identification of ex vivo drug response genes in pediatric acute myeloid leukemia ', Cancers, vol. 12, no. 5, 1247 . https://doi.org/10.3390/cancers12051247
Volume 12
Issue 5
Cancers, Vol 12, Iss 1247, p 1247 (2020)
Cancers, 12(5):1247. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cucchi, D G J, Bachas, C, van den Heuvel-Eibrink, M M, Arentsen-Peters, S T C J M, Kwidama, Z J, Schuurhuis, G J, Assaraf, Y G, de Haas, V, Kaspers, G J L & Cloos, J 2020, ' Harnessing gene expression profiles for the identification of ex vivo drug response genes in pediatric acute myeloid leukemia ', Cancers, vol. 12, no. 5, 1247 . https://doi.org/10.3390/cancers12051247
Volume 12
Issue 5
Novel treatment strategies are of paramount importance to improve clinical outcomes in pediatric AML. Since chemotherapy is likely to remain the cornerstone of curative treatment of AML, insights in the molecular mechanisms that determine its cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41e327c3ac94609fb1d112ffbe92331
https://pure.eur.nl/en/publications/cf7197f9-cf60-48ae-bc51-835954908fdd
https://pure.eur.nl/en/publications/cf7197f9-cf60-48ae-bc51-835954908fdd
Autor:
Birgit I. Lissenberg-Witte, Eveline S. J. M. de Bont, Marry M. van den Heuvel-Eibrink, Barbara Denys, Barbara De Moerloose, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Edwin Sonneveld, Zinia J. Kwidama, Sonja Zweegman, Valerie de Haas, Gertjan J.L. Kaspers, Jan Philippé, Tamás Csikós, Femke Verwer, Jeroen Janssen, Jacqueline Cloos, Karl Vandepoele, David G. J. Cucchi, C. Michel Zwaan
Publikováno v:
Blood, 131(22), 2485-2489. AMER SOC HEMATOLOGY
Zweegman, S & Cucchi, DGJ 2018, ' RNA-based FLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML ', Blood, vol. 131, no. 22, pp. 2485-2489 . https://doi.org/10.1182/blood-2017-12-819508
Blood, 131(22), 2485-2489. American Society of Hematology
Zweegman, S & Cucchi, DGJ 2018, ' RNA-based FLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML ', Blood, vol. 131, no. 22, pp. 2485-2489 . https://doi.org/10.1182/blood-2017-12-819508
Blood, 131(22), 2485-2489. American Society of Hematology
Controversy exists whether internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3-internal tandem duplication [ITD]) allelic ratio (AR) and/or length of the ITD should be taken into account for risk stratification of pediatric acute myeloid
Autor:
Sonja Zweegman, Alexander A. Henneman, Connie R. Jimenez, Adil Al Hinai, Zinia J. Kwidama, Sander R. Piersma, David G. J. Cucchi, Bo J. van Kuijk, Jaco C. Knol, Jeroen Janssen, Thang V. Pham, Carolien van Alphen, Jacqueline Cloos
Publikováno v:
HemaSphere. Wolters Kluwer Health
HemaSphere
HemaSphere, Vol 5, Iss 7, p e606 (2021)
HemaSphere, 6(7):e606. Wolters Kluwer Health
Cucchi, D G J, van Alphen, C, Zweegman, S, van Kuijk, B, Kwidama, Z J, Al Hinai, A, Henneman, A A, Knol, J C, Piersma, S R, Pham, T V, Jimenez, C R, Cloos, J & Janssen, J J W M 2021, ' Phosphoproteomic characterization of primary AML samples and relevance for response toward FLT3-inhibitors ', HemaSphere . https://doi.org/10.1097/HS9.0000000000000606
HemaSphere
HemaSphere, Vol 5, Iss 7, p e606 (2021)
HemaSphere, 6(7):e606. Wolters Kluwer Health
Cucchi, D G J, van Alphen, C, Zweegman, S, van Kuijk, B, Kwidama, Z J, Al Hinai, A, Henneman, A A, Knol, J C, Piersma, S R, Pham, T V, Jimenez, C R, Cloos, J & Janssen, J J W M 2021, ' Phosphoproteomic characterization of primary AML samples and relevance for response toward FLT3-inhibitors ', HemaSphere . https://doi.org/10.1097/HS9.0000000000000606
Autor:
Zinia J. Kwidama, Arjo R. Rutten, Gert J.L. Kaspers, Jacqueline Cloos, Gert J. Ossenkoppele, Guus Westra, Bijan Moshaver, Sonja Zweegman, Angèle Kelder, Rolf Wouters, Gerrit Jan Schuurhuis
Publikováno v:
Leukemia Research, 81, 27-34. Elsevier Limited
Moshaver, B, Wouters, R F, Kelder, A, Ossenkoppele, G J, Westra, G A H, Kwidama, Z, Rutten, A R, Kaspers, G J L, Zweegman, S, Cloos, J & Schuurhuis, G J 2019, ' Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia ', Leukemia Research, vol. 81, pp. 27-34 . https://doi.org/10.1016/j.leukres.2019.04.004
Moshaver, B, Wouters, R F, Kelder, A, Ossenkoppele, G J, Westra, G A H, Kwidama, Z, Rutten, A R, Kaspers, G J L, Zweegman, S, Cloos, J & Schuurhuis, G J 2019, ' Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia ', Leukemia Research, vol. 81, pp. 27-34 . https://doi.org/10.1016/j.leukres.2019.04.004
Leukemic stem cells (LSCs), defined by CD34/CD38 expression, are believed to be essential for leukemia initiation and therapy resistance in acute myeloid leukemia. In addition, the side population (SP), characterized by high Hoechst 33342 efflux, ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c670abc779baaf92e630cbde304da081
https://research.vumc.nl/en/publications/ca980246-4a24-4904-b4aa-53285db29f62
https://research.vumc.nl/en/publications/ca980246-4a24-4904-b4aa-53285db29f62
Autor:
Rosa van Amerongen, Bas Kersten, Gert J. Ossenkoppele, Wendelien Zeijlemaker, Zinia J. Kwidama, Rolf Wouters, Gertjan J.L. Kaspers, Matthijs Valkering, Gerrit Jan Schuurhuis, Peter J. M. Valk, Diana Hanekamp, Jacqueline Cloos
Publikováno v:
Kersten, B, Valkering, M, Wouters, R, van Amerongen, R, Hanekamp, D, Kwidama, Z, Valk, P, Ossenkoppele, G, Zeijlemaker, W, Kaspers, G, Cloos, J & Schuurhuis, G J 2016, ' CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia ', British Journal of Haematology, vol. 173, no. 2, pp. 219-235 . https://doi.org/10.1111/bjh.13941
British Journal of Haematology, 173(2), 219-235. Wiley-Blackwell Publishing Ltd
British Journal of Haematology, 173(2), 219-235. Wiley-Blackwell
British Journal of Haematology, 173(2), 219-235. Wiley-Blackwell Publishing Ltd
British Journal of Haematology, 173(2), 219-235. Wiley-Blackwell
Chemotherapy resistant leukaemic stem cells (LSC) are thought to be responsible for relapses after therapy in acute myeloid leukaemia (AML). Flow cytometry can discriminate CD34(+) CD38(-) LSC and normal haematopoietic stem cells (HSC) by using aberr
Autor:
C. Michel Zwaan, Jacqueline Cloos, Eveline S. J. M. de Bont, Erik R Abels, Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Josta Parigger, Zinia J. Kwidama, Mahban Irandoust, Timo K. van den Berg, Ewart de Bruijn, Mercan Akyuz, Edwin Cuppen, Valerie de Haas, Dirk Reinhardt, Yehuda G. Assaraf, Nika Heijmans, David G. J. Cucchi, Richard Broekhuizen
Publikováno v:
Journal of Molecular and Clinical Medicine, 1(1):DOI: 10.31083/j.jmcm.2018.01.001, 1-6
Cloos, J, Cucchi, DGJ, Irandoust, M, Assaraf, Y G, Kaspers, GJL, Akyuz, M, Broekhuizen, A J F, Heijmans, N, Abels, E R, Parigger, J, Kwidama, ZJ, van den Berg, T K, de Haas, V, Reinhardt, D, M van den Heuvel-Eibrink, M, De Bont, E S J M, Zwaan, C M, Cuppen, E & de Bruijn, E 2017, ' Phosphatase Sequencing of Pediatric Acute Myeloid Leukemia Reveals a Novel Mutation in the Phosphatase Gene PTPN4 ', Journal of Molecular and Clinical Medicine, vol. 1, no. 1, DOI: 10.31083/j.jmcm.2018.01.001, pp. 1-6 . < http://www.imrpress.org/upload/pdf/logo_15390491601127967179.pdf >
Cloos, J, Cucchi, DGJ, Irandoust, M, Assaraf, Y G, Kaspers, GJL, Akyuz, M, Broekhuizen, A J F, Heijmans, N, Abels, E R, Parigger, J, Kwidama, ZJ, van den Berg, T K, de Haas, V, Reinhardt, D, M van den Heuvel-Eibrink, M, De Bont, E S J M, Zwaan, C M, Cuppen, E & de Bruijn, E 2017, ' Phosphatase Sequencing of Pediatric Acute Myeloid Leukemia Reveals a Novel Mutation in the Phosphatase Gene PTPN4 ', Journal of Molecular and Clinical Medicine, vol. 1, no. 1, DOI: 10.31083/j.jmcm.2018.01.001, pp. 1-6 . < http://www.imrpress.org/upload/pdf/logo_15390491601127967179.pdf >
It has been well established that dysregulated activation of kinases is essential for the development of acute myeloid leukemia(AML). In contrast, little is known about the role of their dephosphorylation counterparts, the tyrosine phosphatases. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf1bf3cefe65c288bab8d5d0e06b797
https://research.vumc.nl/en/publications/94d80fce-ae4e-49ae-ad72-ee74a717f3d7
https://research.vumc.nl/en/publications/94d80fce-ae4e-49ae-ad72-ee74a717f3d7
Autor:
Ursula Creutzig, C. Michel Zwaan, Gertjan J.L. Kaspers, Gerrit Jan Schuurhuis, Valerie de Haas, Iris H.I.M. Hollink, Dirk Reinhardt, Yehuda G. Assaraf, Costa Bachas, Eveline S. J. M. de Bont, Bianca F. Goemans, Zinia J. Kwidama, Marry M. van den Heuvel-Eibrink, Jacqueline Cloos
Publikováno v:
Bachas, C, Schuurhuis, G J, Hollink, I H I M, Kwidama, Z J, Goemans, B F, Zwaan, C M, van den Heuvel-Eibrink, M, De Bont, E S J M, Reinhardt, D, Creutzig, U, de Haas, V, Assaraf, Y G, Kaspers, G J L & Cloos, J 2010, ' High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine ', Blood, vol. 116, no. 15, pp. 2752-2758 . https://doi.org/10.1182/blood-2010-03-276519
Blood, 116(15), 2752-2758. American Society of Hematology
Blood, 116(15), 2752-2758. AMER SOC HEMATOLOGY
Blood, 116(15), 2752-2758. American Society of Hematology
Blood, 116(15), 2752-2758. AMER SOC HEMATOLOGY
Although virtually all pediatric patients with acute myeloid leukemia (AML) achieve a complete remission after initial induction therapy, 30%-40% of patients will encounter a relapse and have a dismal prognosis. To prevent relapses, personalized trea