Výsledky vyhledávání - "Zinc-binding group"

Akademický článek

Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques

Autor: Fetian MH, Al-Balas QA

Publikováno v: Advances and Applications in Bioinformatics and Chemistry, Vol Volume 17, Pp 21-32 (2024)

Mohammad H Fetian, Qosay A Al-Balas Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Qosay A Al-Balas, Department of Medicinal Chemistry & Pharmacognos

Externí odkaz: https://doaj.org/article/d35a2e39e2884ab68b5d62cba857f44c

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Akademický článek

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors

Autor: Khulood H. Oudah, Walaa R. Mahmoud, Fadi M. Awadallah, Azza T. Taher, Safinaz E.-S Abbas, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 12-23 (2023)

The present investigation reports the design and synthesis of three series of benzoylthioureido derivatives bearing either benzenesulfonamide 7a–f, benzoic acid 8a–f or ethylbenzoate 9a–f moieties. The synthesised compounds were screened for th

Externí odkaz: https://doaj.org/article/9079e92375a74694abaf13dca32085d8

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Akademický článek

Medicinal chemistry advances in targeting class I histone deacetylases

Autor: Diaaeldin I. Abdallah, Elvin D. de Araujo, Naman H. Patel, Lina S. Hasan, Richard Moriggl, Oliver H. Krämer, Patrick T. Gunning

Publikováno v: Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 757-779 (2023)

Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight regulation

Externí odkaz: https://doaj.org/article/34581887751b4ed39c2cde49dcc5b039

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Akademický článek

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Akademický článek

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

Autor: Pasquale Linciano, Luca Pinzi, Silvia Belluti, Ugo Chianese, Rosaria Benedetti, Davide Moi, Lucia Altucci, Silvia Franchini, Carol Imbriano, Claudia Sorbi, Giulio Rastelli

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2080-2086 (2021)

Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HD

Externí odkaz: https://doaj.org/article/18d2ffd0a92246498fd6e5733f045e19

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Akademický článek

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

Autor: Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasiia Gryniukova, Petro Borysko, Andrea Angeli, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 306-310 (2020)

The differential scanning fluorimetry (DSF) screening of 5.692 fragments in combination with benzenesulfonamide (BSA) against bovine carbonic anhydrase (bCA) delivered >100 hits that either caused, on their own, a significant thermal shift (ΔTm, °C

Externí odkaz: https://doaj.org/article/fc10cfcdab0649f8818c3aee44de95e6

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Akademický článek

Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

Autor: Mikhail Krasavin, Tatiana Sharonova, Vladimir Sharoyko, Daniil Zhukovsky, Stanislav Kalinin, Raivis Žalubovskis, Tatiana Tennikova, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 665-671 (2020)

A hypothesis that simultaneous targeting cancer-related carbonic anhydrase hCA IX and hCA XII isoforms (whose overexpression is a cancer cell’s defence mechanism against hypoxia) along with thioredoxin reductase (overexpressed in cancers as a defen

Externí odkaz: https://doaj.org/article/9fbf8a07c7cf4db2bb258d9ed824a75f

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Akademický článek

Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors

Autor: Samar A. El-Kalyoubi, Ehab S. Taher, Tarek S. Ibrahim, Mohammed Farrag El-Behairy, Amany M. M. Al-Mahmoudy

Publikováno v: Pharmaceuticals, Vol 15, Iss 5, p 494 (2022)

A series of quinoline–uracil hybrids (10a–l) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored. Compounds 10a–l demonstrated powerful inhibitory activity against all tested hCA i

Externí odkaz: https://doaj.org/article/ba1011e7b67d4fe2bed1d304b66199bf

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