Evolutionary conservation of Zinc-Activated Channel (ZAC) functionality in mammals: a range of mammalian ZACs assemble into cell surface-expressed functional receptors

Autor: Anders A. Jensen

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

In contrast to the other pentameric ligand-gated ion channels in the Cys-loop receptor superfamily, the ZACN gene encoding for the Zinc-Activated Channel (ZAC) is exclusively found in the mammalian genome. Human ZAC assembles into homomeric cation-se

Externí odkaz: https://doaj.org/article/d9e4a751df1d469699c18d4f5edec2b2

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr(128)Ala variant (rs2257020) in Xenopus oocytes

Autor: Nawid Madjroh, Uffe Kristiansen, Pella Cecilia Söderhielm, Joshua L. Smalley, Anders A. Jensen, Paul Davies

Publikováno v: Pharmacol Res
Madjroh, N, Davies, P A, Smalley, J L, Kristiansen, U, Söderhielm, P C & Jensen, A A 2021, ' Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr 128 Ala variant (rs2257020) in Xenopus oocytes ', Pharmacological Research, vol. 169, 105653 . https://doi.org/10.1016/j.phrs.2021.105653

The signalling characteristics of the Zinc-Activated Channel (ZAC), a member of the Cys-loop receptor (CLR) superfamily, are presently poorly elucidated. The ZACN polymorphism c.454G>A encoding for the Thr128Ala variation in ZAC is found in extremely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a232df82964af2e1e7d718ac3b4ba
https://europepmc.org/articles/PMC8248299/

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