Výsledky vyhledávání - "Zinc Fingers/genetics"

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Autor: Warren J. Leonard, Nima Rezaei, Kathryn Payne, Isabelle Meyts, Laurent Abel, Cindy S. Ma, Marianne Leruez-Ville, Janet Chou, Alain Hovnanian, Jian-Xin Lin, Simon J. Pelham, Danielle T. Avery, Matthieu Bouaziz, Bethany Pillay, Tanwir Habib, Anne Puel, Sevgi Keles, Juan Li, Isabelle Pellier, Jamel El-Benna, Bernhard Fleckenstein, Ahmet Ozen, Vivien Béziat, Ingrid Müller-Fleckenstein, Damien Chaussabel, Samaneh Zoghi, Yi Wang, Paul Gray, Matthias Titeux, Yoann Zerbib, Talal A. Chatila, Marie-Alexandra Alyanakian, Capucine Picard, Orli Wargon, Ayper Somer, Marie-Olivia Chandesris, Thibaut Leclercq, Ibtihal Benhsaien, Aziz Belkadi, Jean-Laurent Casanova, Romain Lévy, Peng Li, Geetha Rao, Ai Ing Lim, James P. Di Santo, Nico Marr, Sylvie Fraitag, Frédégonde About, Elissa K. Deenick, Bertrand Boisson, Jacinta Bustamante, Mélanie Migaud, Bodo Grimbacher, Aziz Bousfiha, Fatima Ailal, Safa Baris, Antoine Guérin, Stuart G. Tangye, Romain Guery, Ning Du, Vimel Rattina

Publikováno v: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩

Comment in :Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song. [Sci Immunol. 2018]; International audience; Heterozygosity for human signal transducer and activator of transcription 3 (STAT3) dominant-negative (DN) mutations u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014e03bf19bbdfb4eb205a53e190a3a
https://doi.org/10.1126/sciimmunol.aat4956

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ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

Autor: Robert J. Klose, Neil P. Blackledge, Hannah K. Long

Publikováno v: Long, H K, Blackledge, N P & Klose, R J 2013, ' ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection ', Biochemical Society Transactions, vol. 41, no. 3, pp. 727-40 . https://doi.org/10.1042/BST20130028
Biochemical Society Transactions

Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates a binding site for MBD (methyl-CpG-binding domain) proteins which target chromatin-modifyin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d23e5886961723d395fb4798c63f76
https://ora.ox.ac.uk/objects/uuid:194ec326-8549-4a6f-a9fd-66f9001fc79c

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Chloroplast retrograde signal regulates flowering

Autor: Xuwu Sun, Haiyang Wang, Xiumei Xu, Jinfang Ma, Lixin Zhang, Hailong Guo, Congming Lu, Jean-David Rochaix, Peiqiang Feng, Wei Chi, Dario Leister, Xin Chai

Publikováno v: Proceedings of the National Academy of Sciences, Vol. 113, No 38 (2016) pp. 10708-10713

Significance Proper timing of flowering transition is vital for the reproductive success of plants and orchestrated by endogenous and external factors; however, the mechanisms of how plants regulate flowering under high light are not well understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79f38ecf505dde84e75748016fe17c0
https://archive-ouverte.unige.ch/unige:111261

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Isolation and Initial Characterization of a Novel Zinc Finger Gene, DNMT3L, on 21q22.3, Related to the Cytosine-5- Methyltransferase 3 Gene Family

Autor: Kazunori Shibuya, Juha Ollila, Jun Kudoh, Ai Shintani, Maarit Heino, Nobuyoshi Shimizu, Mauno Vihinen, Hamish S. Scott, Pärt Peterson, Shinsei Minoshima, Ulla Aapola, Kai Krohn, Stylianos E. Antonarakis, Kazuhiko Kawasaki

Publikováno v: Genomics, Vol. 65, No 3 (2000) pp. 293-298

We have isolated the DNMT3L gene that is related to the cytosine-5-methyltransferase 3 (DNMT3) family. The gene is located on chromosome 21q22.3 between the AIRE and the KIAA0653 genes and spans approximately 16 kb of genomic sequence. The encoded pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b23958df0f3970bdb586da0411c986
https://doi.org/10.1006/geno.2000.6168

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Positional cloning of the APECED gene

Autor: Stylianos E. Antonarakis, Kazuhiko Kawasaki, Maarit Heino, Hamish S. Scott, Nobuyoshi Shimizu, Shuichi Asakawa, Maria D. Lalioti, Kentaro Nagamine, Primus E. Mullis, Shinsei Minoshima, Fumiaki Ito, Pärt Peterson, Kai Krohn, Jun Kudoh

Publikováno v: Scopus-Elsevier
Nature Genetics, Vol. 17, No 4 (1997) pp. 393-398

Autoimmune polyglandular syndrome type I (APS 1, also called APECED) is an autosomal-recessive disorder that maps to human chromosome 21q22.3 between markers D21S49 and D21S171 by linkage studies. We have isolated a novel gene from this region, AIRE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8a6c8a8e5b14253107096e4d48c14b
https://doi.org/10.1038/ng1297-393

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Differential Sensitivity of Zinc Finger Transcription Factors MTF-1, Sp1 and Krox-20 to CpG Methylation of Their Binding Sites

Autor: Koichi Matsuo, Walter Schaffner, Freddy Radtke, Oleg Georgiev, Martin Hug

Publikováno v: Biological Chemistry Hoppe-Seyler. 377:47-56

Cytosine methylation at CpG sites is often negatively correlated with mammalian gene activity. Many transcription factors whose DNA binding site contains one or more CpG dinucleotides are no longer able to efficiently bind DNA when the site is methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c19555a6c50f1e50ad944098455557d
https://doi.org/10.1515/bchm3.1996.377.1.47

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The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains both a GATA-1 type zinc finger and a putative leucine zipper

Autor: David Coornaert, Stephan Vissers, Marcelle Grenson, Bruno André

Publikováno v: Current genetics, 21 (4-5

The UGA43 gene of Saccharomyces cerevisiae is required for repression of inducible genes involved in the utilization of 4-aminobutyric acid (GABA) or urea as nitrogen sources. The UGA43 gene has been cloned by complementation of a uga43 mutation. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7695267b3cd7c4fb25187c1719300ead
https://doi.org/10.1007/bf00351687

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The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box

Autor: Fabienne Cléard, Pierre Spierer, Marie Matsarskaia

Publikováno v: Nucleic Acids Research, Vol. 23, No 5 (1995) pp. 796-802

An increase in the number of copies of the Drosophila locus Suvar(3)7 enhances position-effect variegation, i.e. the inactivation in some cells of genes brought close to heterochromatin by a chromosomal rearrangement. The locus produces two transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78440f2818b2dc5cfb63207367409d1f
https://archive-ouverte.unige.ch/unige:9870

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