Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zinal Chheda"'
Autor:
Rajesh K. Sharma, Venkatakrishna R. Jala, Sweta Ghosh, Michelle E Smith, Zinal Chheda, Rajbir Singh, Sobha R. Bodduluri, Jun Yan, Bodduluri Haribabu, Steven P. Mathis, Paula M. Chilton, Chris Fleming, Rob Knight
Publikováno v:
International Journal of Cancer. 148:2594-2607
The biological activities of chemokine (C-C motif) ligand 2 (CCL2) are mediated via C-C chemokine receptor-2 (CCR2). Increased CCL2 level is associated with metastasis of many cancers. In this study, we investigated the role of the CCL2/CCR2 axis in
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 24, iss 21
The field of cancer immunotherapy has made exciting progress for some cancer types in recent years. However, recent failures of late-phase clinical trials evaluating checkpoint blockade in patients with glioblastoma (GBM) represent continued challeng
Autor:
Theodore L. Roth, Zinal Chheda, Hideho Okada, David N. Nguyen, Bindu Hegde, Ryan Apathy, Alexander Marson
Publikováno v:
Neuro Oncol
We recently identified an HLA-A*02:01-restricted CD8 T cell epitope encompassing the H3.3K27M mutation, which is common in diffuse midline glioma, and a corresponding high-affinity T cell receptor (TCR) that recognizes the epitope. While recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364fde0ed6dcd0be8482dfe1412c1fa4
https://europepmc.org/articles/PMC6847734/
https://europepmc.org/articles/PMC6847734/
Publikováno v:
Neuro Oncol
The lack of conventional lymphatic drainage to and from the brain parenchyma restricts the capacity of the peripheral immune system to recognize and respond to glioma antigens. In some peripheral solid tumor types and central nervous system autoimmun
Publikováno v:
Cancer Research. 81:74-74
The absence of conventional lymphatic access to the brain parenchyma restricts the capacity of the peripheral immune system to recognize and elicit durable responses against glioma antigens. In some peripheral solid tumor types and autoimmune disease
Autor:
Biswa Pratim Das Purkayastha, Bodduluri Haribabu, Jorge G. Gomez-Gutierrez, Zinal Chheda, Venkatakrishna R. Jala, Rajesh K. Sharma
Publikováno v:
Clinical & Experimental Metastasis. 33:263-275
Metastasis causes most cancer related mortality but the mechanisms governing metastatic dissemination are poorly defined. Metastasis involves egression of cancer cells from the primary tumors, their survival in circulation and colonization at the sec
Autor:
Pavlina Chuntova, Kira Downey, Shuming Liu, Yi Lin, Alessandro Sette, Shruti Shrivastav, K. Christopher Garcia, Sabine Mueller, Matteo Pecoraro, Kaori Okada, Naznin Jahan, John Sidney, Matthias Mann, Diego Carrera, Hideho Okada, Angel M. Carcaboso, Yafei Hou, Xinbo Yang, Raja Rajalingam, Ian F. Pollack, Payal Watchmaker, Zinal Chheda, Chetana Lagisetti, Gary Kohanbash
Publikováno v:
The Journal of experimental medicine, vol 215, iss 1
The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
In this issue of JEM, Chheda et al. report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a “public” neoantigen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6afda629218cda032e36d6b50415cd3
https://escholarship.org/uc/item/0n6719zf
https://escholarship.org/uc/item/0n6719zf
Publikováno v:
Expert Review of Vaccines. 14:537-549
Cancer immunotherapy has recently emerged as an important treatment modality. FDA approval of provenge, ipilimumab and pembrolizumab has started to deliver on the long awaited promise of cancer immunotherapy. Many new modalities of immunotherapies ta
Autor:
Venkatakrishna R. Jala, Zinal Chheda, Sobha R. Bodduluri, Bodduluri Haribabu, Shuchismita R. Satpathy, Rajesh K. Sharma
The high affinity leukotriene B4 receptor, BLT1 mediates chemotaxis of diverse leukocyte subsets to the sites of infection or inflammation. Whereas the pathological functions of LTB4/BLT1 axis in allergy, autoimmunity and cardiovascular disorders are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620a40475c2e72285e9b87ffa65eb25a
https://europepmc.org/articles/PMC5647256/
https://europepmc.org/articles/PMC5647256/
Autor:
Christel Herold-Mende, Casey Beppler, Joseph F. Costello, Payal Watchmaker, Rolf Warta, Hideho Okada, Kira Downey, Shruti Shrivastav, Brian Ahn, Zinal Chheda, Gary Kohanbash, Tali Mazor, Naznin Jahan, Nduka A. Amankulor, Diego Carrera
Publikováno v:
The Journal of clinical investigation, vol 127, iss 4
Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-grade glioma (LGG). LGG-associated IDH mutations confer gain-of-function activity by converting α-ketoglut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3192183d6ee5203a9883d15ab4435d64
https://escholarship.org/uc/item/4dx77038
https://escholarship.org/uc/item/4dx77038