Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Zinaida S Vexler"'
Autor:
Tetyana Chumak, Amandine Jullienne, C. Joakim Ek, Maryam Ardalan, Pernilla Svedin, Ryan Quan, Arjang Salehi, Sirus Salari, Andre Obenaus, Zinaida S Vexler, Carina Mallard
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Infection during the perinatal period can adversely affect brain development, predispose infants to ischemic stroke and have lifelong consequences. We previously demonstrated that diet enriched in n-3 polyunsaturated fatty acids (n-3 PUFA) t
Externí odkaz:
https://doaj.org/article/171dee11aa984a618f77b1c77a287ac0
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy. Exper
Externí odkaz:
https://doaj.org/article/eb065f617d0148aba2ec071911387e06
Autor:
Dezhi Mu, Xiangning Jiang, R.Ann Sheldon, Christine K Fox, Shannon E.G Hamrick, Zinaida S Vexler, Donna M Ferriero
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 3, Pp 524-534 (2003)
Stroke is a devastating condition occurring in at least 1 in 4000 live births in the neonatal period. Since hypoxia-inducible factor (HIF)-1α can modulate ischemic injury via induction of target genes that may protect cells against ischemia, and is
Externí odkaz:
https://doaj.org/article/dc1d3f55e6cf425697bd3390aef75abe
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Externí odkaz:
https://doaj.org/article/fd425618f7a14951a20cb4d9a96329de
Publikováno v:
iScience, vol 26, iss 4
iScience
iScience
Arterial ischemic stroke is common in neonates-1 per 2,300-5,000 births-and therapeutic targets remain insufficiently defined. Sphingosine-1-phosphate receptor 2 (S1PR2), a major regulator of the CNS and immune systems, is injurious in adult stroke.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c56c3aef74add80b7dac7f08fe63ea
https://escholarship.org/uc/item/4pw9236m
https://escholarship.org/uc/item/4pw9236m
Autor:
Shruti Gururaj Gadagkar, Melanie Lalancette-Hébert, Sai Sampath Thammisetty, Zinaida S. Vexler, Jasna Kriz
Publikováno v:
Scientific Reports. 13
Innate immune response in neonatal brain is associated with a robust microglial activation and induction of Toll-like Receptors (TLRs). To date, the role of the scavenger receptor CD36 in TLRs modulation, particularly TLR2 signaling, has been well es
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Background Ischemic stroke induces the activation and recruitment of peripheral leukocytes to the injured brain. These cells can infiltrate the brain through multiple routes, either by penetrating blood–brain barrier or via blood–CSF barriers at
Publikováno v:
Translational Stroke Research.
Injuries in the developing brain cause significant long-term neurological deficits. Emerging clinical and preclinical data have demonstrated that the pathophysiology of neonatal and childhood stroke share similar mechanisms that regulate brain damage
Autor:
Maryam Ardalan, Matthieu Lecuyer, Carina Mallard, Pernilla Svedin, Zinaida S. Vexler, Joakim Ek, Andre Obenaus, Tetyana Chumak, Anders Nilsson, Joel Faustino, Ulrika Sjöbom
Publikováno v:
Translational Stroke Research. 13:449-461
The fetus is strongly dependent on nutrients from the mother, including polyunsaturated fatty acids (PUFA). In adult animals, n-3 PUFA ameliorates stroke-mediated brain injury, but the modulatory effects of different PUFA content in maternal diet on
Autor:
Jacqueline Strivelli, Praneeti Pathipati, Joel Faustino, Matthieu Lecuyer, Zinaida S. Vexler, Donald G. Phinney
Publikováno v:
Neurotherapeutics
Mesenchymal stem cell (MSC)-based therapies are beneficial in models of perinatal stroke and hypoxia–ischemia. Mounting evidence suggests that in adult injury models, including stroke, MSC-derived small extracellular vesicles (MSC-sEV) contribute t