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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.

Autor: Rennie GR; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Barden TC; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Bernier SG; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Carvalho A; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Deming R; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Germano P; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Hudson C; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Im GJ; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Iyengar RR; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Jia L; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Jung J; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Kim E; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Lee TW; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Mermerian A; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Moore J; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Nakai T; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Perl NR; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Tobin J; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Zimmer DP; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States., Renhowe PA; Cyclerion Therapeutics, Inc., 301 Binney Street Cambridge, MA 02142, United States. Electronic address: prenhowe@gmail.com.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 15; Vol. 40, pp. 127886. Date of Electronic Publication: 2021 Mar 02.

Soluble Guanylate Cyclase Stimulators and Activators.

Autor: Sandner P; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, Wuppertal, Germany. peter.sandner@bayer.com.; Department of Pharmacology, Hannover Medical School, Hannover, Germany. peter.sandner@bayer.com., Zimmer DP; Ironwood Pharmaceuticals, Cambridge, MA, USA., Milne GT; Ironwood Pharmaceuticals, Cambridge, MA, USA., Follmann M; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, Wuppertal, Germany., Hobbs A; Barts and the London School of Medicine and Dentistry QMUL, London, UK., Stasch JP; Bayer AG, Pharmaceuticals R&D, Pharma Research Center, Wuppertal, Germany.; Institute of Pharmacy, University Halle-Wittenberg, Halle, Germany.

Publikováno v: Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 264, pp. 355-394.