Sterile Diet Causes Gut Microbiome Collapse of Cancer Patients Post Hematopoietic Cell Transplantation, But Normal Diet Recovers Them

Autor: Wenqing Hong, Yun Wu, Zimin Sun, Shu Yang, Qing Cheng, Huilan Liu, Xiaoxing Lin, Renjie Ni, Yuping Yao, Shuijing Wang, Zihao Zheng, Anyi Sun, Chuanwu Xi, Liyan Song

Publikováno v: Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)

Abstract Though sterile diet, post‐transplantation surgery is a clinical strategy for patient care to prevent the infiltration of gut pathogens, less is known about its effects on the gut microbiome. Here, the gut microbiome dynamics of leukemia pa

Externí odkaz: https://doaj.org/article/4fb16ccfa86c4f4bac121581f2469d8a

Refining eligibility criteria of unit selection for myeloablative cord blood transplantation in acute leukemia: Real‐world experience of a referral center

Autor: Zimin Sun, Yu Hu, Yanping Ji, Xueou Liu, Xiaowen Gong, Yahui Feng, Huilan Liu, Wei Zhang, Saibing Qi, Qiujin Shen, Kaidi Song, Liangquan Geng, Wen Yao, Xiang Wan, Baolin Tang, Xiaoyu Zhu, Guangyu Sun, Ping Qiang, Zhen Song, Junren Chen

Publikováno v: eJHaem, Vol 4, Iss 2, Pp 470-475 (2023)

Abstract The algorithm for cord blood (CB) unit selection is still somewhat ambiguous. We retrospectively analyzed 620 cases of acute leukemia between 2015 and 2020, who were treated with myeloablative single‐unit umbilical CB transplantation (UCBT

Externí odkaz: https://doaj.org/article/a226df0b5485472c97de3742ab0a008a

Efficacy and safety of blinatumomab in Chinese adults with Ph-negative relapsed/refractory B-cell precursor acute lymphoblastic leukemia: A multicenter open-label single-arm China registrational study

Autor: Hongsheng Zhou, Qingsong Yin, Jie Jin, Ting Liu, Zhen Cai, Bin Jiang, Dengju Li, Zimin Sun, Yan Li, Yanjuan He, Liping Ma, Sujun Gao, Jianda Hu, Aili He, Xin Du, Daihong Liu, Xiaohong Zhang, Xiaoyan Ke, Junling Zhuang, Yue Han, Xiaoqin Wang, Yuqi Chen, Paul Gordon, Dong Yu, Gerhard Zugmaier, Jianxiang Wang

Publikováno v: Hematology, Vol 27, Iss 1, Pp 917-927 (2022)

Objectives The prognosis for adults with relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is poor. Blinatumomab is a CD3/CD19-directed BiTE® (bispecific T-cell engager) molecule approved globally for the treatment of

Externí odkaz: https://doaj.org/article/ad3a5cb157c1499d9cbca0b38ec64984

Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Autor: Huisheng Ai, Nelson J. Chao, David A. Rizzieri, Xiaojun Huang, Thomas R. Spitzer, Jianxiang Wang, Mei Guo, Armand Keating, Elizabeth F. Krakow, Didier Blaise, Jun Ma, Depei Wu, John Reagan, Usama Gergis, Rafael F. Duarte, Preet M. Chaudhary, Kaixun Hu, Changlin Yu, Qiyun Sun, Ephraim Fuchs, Bo Cai, Yajing Huang, Jianhui Qiao, David Gottlieb, Kirk R. Schultz, Mingyao Liu, Xiequn Chen, Wenming Chen, Jianmin Wang, Xiaohui Zhang, Jianyong Li, He Huang, Zimin Sun, Fei Li, Linhua Yang, Liansheng Zhang, Lijuan Li, Kaiyan Liu, Jie Jin, Qifa Liu, Daihong Liu, Chunji Gao, Chuanbo Fan, Li Wei, Xi Zhang, Liangding Hu, Weijing Zhang, Yuyang Tian, Weidong Han, Jun Zhu, Zhijian Xiao, Daobin Zhou, Bolong Zhang, Yongqian Jia, Yongqing Zhang, Xiaoxiong Wu, Xuliang Shen, Xuzhang Lu, Xinrong Zhan, Xiuli Sun, Yi Xiao, Jingbo Wang, Xiaodong Shi, Bo Zheng, Jieping Chen, Banghe Ding, Zhao Wang, Fan Zhou, Mei Zhang, Yizhuo Zhang, Jie Sun, Bing Xia, Baoan Chen, Liangming Ma

Publikováno v: Heliyon, Vol 9, Iss 4, Pp e14924- (2023)

Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MS

Externí odkaz: https://doaj.org/article/856fec91f1344a8b9074383ae4ab2604

Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients

Autor: Linlin Jin, Zimin Sun, Huilan Liu, Xiaoyu Zhu, Yonggang Zhou, Binqing Fu, Xiaohu Zheng, Kaidi Song, Baolin Tang, Yun Wu, Jiang Zhu, Rui Sun, Zhigang Tian, Haiming Wei

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Pre-engraftment syndrome is a major consideration during clinical application of unrelated cord blood transfusion and monocytes represent a critical cell type in immune-pathogenesis. Here the authors further establish the role of monocytes and GM-CSF

Externí odkaz: https://doaj.org/article/ee31202e507f4a289156fa265f6fb4f4