Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Zilu Ye"'
Autor:
Jiangbo Song, Zhiquan Li, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen, Fangyin Dai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract FOXO transcription factors modulate aging-related pathways and influence longevity in multiple species, but the transcriptional targets that mediate these effects remain largely unknown. Here, we identify an evolutionarily conserved FOXO tar
Externí odkaz:
https://doaj.org/article/6d8e7769443a4b1ca5a7abe0242df507
Autor:
Zilu Ye, Pierre Sabatier, Javier Martin-Gonzalez, Akihiro Eguchi, Maico Lechner, Ole Østergaard, Jingsheng Xie, Yuan Guo, Lesley Schultz, Rafaela Truffer, Dorte B. Bekker-Jensen, Nicolai Bache, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step processes, presenting challenges with sample losses, reproducibility, requiring substantial time and financial investments, and specialized skills. Here
Externí odkaz:
https://doaj.org/article/5e6153097b5242d18061e20f48ee5094
Publikováno v:
Bio-Protocol, Vol 14, Iss 4 (2024)
Signaling pathways are involved in key cellular functions from embryonic development to pathological conditions, with a pivotal role in tissue homeostasis and transformation. Although most signaling pathways have been intensively examined, most studi
Externí odkaz:
https://doaj.org/article/ea3214a711624223bf7a5f41fdd6e903
Autor:
Zilu Ye, Pierre Sabatier, Javier Martin-Gonzalez, Akihiro Eguchi, Maico Lechner, Ole Østergaard, Jingsheng Xie, Yuan Guo, Lesley Schultz, Rafaela Truffer, Dorte B. Bekker-Jensen, Nicolai Bache, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c178d9f094f64e408819a9a8e044d610
Autor:
Mathias I. Nielsen, Noortje de Haan, Weston Kightlinger, Zilu Ye, Sally Dabelsteen, Minyan Li, Michael C. Jewett, Ieva Bagdonaite, Sergey Y. Vakhrushev, Hans H. Wandall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Information about O-glycosylation site regulation and occupancy in the human proteome is limited. Here, the authors identify GalNAc transferase-specific glycan sites in human keratinocytes and describe their occupancy.
Externí odkaz:
https://doaj.org/article/fbcbe6fae32e48b89c701700d06d9141
Autor:
Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias A.I. Nielsen, Ming Song, Caroline B.K. Mathiesen, Jesse Stoop, Sean Stowell, Per Thor Straten, Hakon Leffler, Sergey Y. Vakhrushev, Sally Dabelsteen, Jesper V. Olsen, Hans H. Wandall
Publikováno v:
iScience, Vol 26, Iss 7, Pp 106984- (2023)
Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extra
Externí odkaz:
https://doaj.org/article/5c38b67b7b324db0855f8aa5f59ead4a
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Ye et al. address a highly debated aspect of many recent single cell proteomics studies, the extent and impact of the carrier proteome. Through deployment of a mixed-species sample at various spike-in levels, they set up an experimental system for fu
Externí odkaz:
https://doaj.org/article/6f5777034716462698541433362f6af9
Autor:
Yen-Hsi Chen, Weihua Tian, Makiko Yasuda, Zilu Ye, Ming Song, Ulla Mandel, Claus Kristensen, Lorenzo Povolo, André R. A. Marques, Tomislav Čaval, Albert J. R. Heck, Julio Lopes Sampaio, Ludger Johannes, Takahiro Tsukimura, Robert Desnick, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hams
Externí odkaz:
https://doaj.org/article/8ae81d7ac9d04563824966c741e0198e
Autor:
Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Gestur Vidarsson, Henrik Clausen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG with FcγRs and the resulting effector functions, which has led to the
Externí odkaz:
https://doaj.org/article/d3ca065183164628bb92e4118236f671
Autor:
Rebecca Nason, Christian Büll, Andriana Konstantinidi, Lingbo Sun, Zilu Ye, Adnan Halim, Wenjuan Du, Daniel M. Sørensen, Fabien Durbesson, Sanae Furukawa, Ulla Mandel, Hiren J. Joshi, Leo Alexander Dworkin, Lars Hansen, Leonor David, Tina M. Iverson, Barbara A. Bensing, Paul M. Sullam, Ajit Varki, Erik de Vries, Cornelis A. M. de Haan, Renaud Vincentelli, Bernard Henrissat, Sergey Y. Vakhrushev, Henrik Clausen, Yoshiki Narimatsu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mucins play critical roles in maintaining the human microbiome, with their O-glycosylated tandem repeats (TRs) providing important cues for microbiota. Here, the authors develop a cellular platform for producing TRs with defined O-glycan structures t
Externí odkaz:
https://doaj.org/article/052ba3410c8a4710a0be9d4b267f2de3