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The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.

Autor: Nimmanon, Thirayost, Ziliotto, Silvia, Ogle, Olivia, Burt, Anna, Gee, Julia M. W., Andrews, Glen K., Kille, Pete, Hogstrand, Christer, Maret, Wolfgang, Taylor, Kathryn M.

Publikováno v: Cellular & Molecular Life Sciences; Feb2021, Vol. 78 Issue 4, p1781-1798, 18p

Understanding how targeting zinc\ud transporters prevents the development\ud of aggressive cancer

Autor: Ziliotto, Silvia

Zinc is one of the most abundant trace elements in the human body. Cellular zinc\ud homeostasis is primarily controlled by zinc transporters, including the ZIP family of zinc\ud importers. Since zinc homeostasis needs to be tightly controlled, dysreg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::791b618fe6e5ee289e9a3593f7f279f5
https://orca.cardiff.ac.uk/id/eprint/121512/2/2019ZiliottoSphd.pdf

Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer.

Autor: Ziliotto S; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk., Gee JMW; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk., Ellis IO; Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK., Green AR; Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK., Finlay P; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk., Gobbato A; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk., Taylor KM; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk.

Publikováno v: Metallomics : integrated biometal science [Metallomics] 2019 Sep 01; Vol. 11 (9), pp. 1579-1592. Date of Electronic Publication: 2019 Sep 04.

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.

Autor: Taylor KM; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K. TaylorKM@cardiff.ac.uk christer.hogstrand@kcl.ac.uk., Muraina IA; King's College London, Faculty of Life Sciences and Medicine, Diabetes and Nutritional Sciences, Metal Metabolism Group, 150 Stamford St., London SE1 NH9, U.K. National Veterinary Research Institute, PMB 01 Vom, Nigeria., Brethour D; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5T 3S8 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 3H2., Schmitt-Ulms G; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5T 3S8 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 3H2., Nimmanon T; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K. Department of Pathology, Phramongkutklao College of Medicine, 315 Ratchawithi Road, Thung Phayathai, Ratchathewi, Bangkok 10400, Thailand., Ziliotto S; Breast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K., Kille P; School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AT, U.K., Hogstrand C; King's College London, Faculty of Life Sciences and Medicine, Diabetes and Nutritional Sciences, Metal Metabolism Group, 150 Stamford St., London SE1 NH9, U.K. TaylorKM@cardiff.ac.uk christer.hogstrand@kcl.ac.uk.

Publikováno v: The Biochemical journal [Biochem J] 2016 Aug 15; Vol. 473 (16), pp. 2531-44. Date of Electronic Publication: 2016 Jun 07.