Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Zili Xiao"'
Autor:
Zhixia Dong, Xiangyun Zhao, Hangbin Zheng, HanYao Zheng, Dafan Chen, Jia Cao, Zili Xiao, Yunwei Sun, Qian Zhuang, Shan Wu, Jie Xia, Min Ning, Binjie Qin, Hui Zhou, Jinsong Bao, Xinjian Wan
Publikováno v:
EClinicalMedicine, Vol 73, Iss , Pp 102656- (2024)
Summary: Background: Gastrointestinal stromal tumors (GISTs) represent the most prevalent type of subepithelial lesions (SELs) with malignant potential. Current imaging tools struggle to differentiate GISTs from leiomyomas. This study aimed to create
Externí odkaz:
https://doaj.org/article/277970b4f16646a7a176bdfcbf3b311e
Autor:
Wenjing Chi, Su Wang, Tao Liu, Wenrong Jiang, Li Ding, Yingxin Miao, Feng Yang, Jinghao Zhang, Danian Ji, Zili Xiao, Haowei Zhu, Yong Wu, Zhijun Bao, Hu Zhao, Shiwen Wang
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
AimThis study established a high-throughput multiplex genetic detection assay (HMGA) for rapid identification, semi-quantification and virulence analysis of Helicobacter pylori directly from the clinical non-invasive oral samples.MethodsThe gastric m
Externí odkaz:
https://doaj.org/article/a094398522e4481ca000daa221473d49
Autor:
Wenjing Chi, Su Wang, Tao Liu, Wenrong Jiang, Li Ding, Yingxin Miao, Feng Yang, Jinghao Zhang, Danian Ji, Zili Xiao, Haowei Zhu, Yong Wu, Zhijun Bao, Hu Zhao, Shiwen Wang
Publikováno v:
Frontiers in Cellular & Infection Microbiology; 2023, p1-13, 13p
Publikováno v:
Digestion. 103:69-75
Background: With the development of new technologies such as magnifying endoscopy with narrow band imaging, endoscopists achieved better accuracy for diagnosis of gastric cancer (GC) in various aspects. However, to master such skill takes substantial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f55ee73a1d8dbc10d87dff6382b22a
https://doi.org/10.1159/000519601
https://doi.org/10.1159/000519601
Autor:
Andrew J. Tebben, Sandhya Mandlekar, Michael A. Gallela, Songmei Xu, Robert J. Cherney, Mary Ellen Cvijic, Anne Rose, John V. Duncia, Mary F. Malley, Yang Michael G, Arvind Mathur, Percy H. Carter, Amy A. Sarjeant, Jian Pang, Bei Wang, Zili Xiao, Ragini Vuppugalla, Purnima Khandelwal, Qihong Zhao, Gardner Daniel S, Joseph B. Santella, Douglas G. Batt, Gregory D. Brown, Rulin Zhao
Publikováno v:
ACS Med Chem Lett
[Image: see text] To improve the metabolic stability profile of BMS-741672 (1a), we undertook a structure–activity relationship study in our trisubstituted cyclohexylamine series. This ultimately led to the identification of 2d (BMS-753426) as a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f70e15f407bd4570156fbac55e9e1f1
https://doi.org/10.1021/acsmedchemlett.1c00082
https://doi.org/10.1021/acsmedchemlett.1c00082
Autor:
Aberra Fura, Shiuhang Yip, Georgia Cornelius, Hai-Yun Xiao, Qingjie Liu, Sha Li, Ning Li, Nicholas A. Meanwell, Shailesh Dudhgaonkar, Max Ruzanov, Jenny Xie, Zili Xiao, Purnima Khandelwal, Carolyn A. Weigelt, David J. Shuster, Dauh-Rurng Wu, T. G. Murali Dhar, Tara Sherry, Yang Michael G, Kevin Stefanski, Jignesh Nagar, Rex Denton, Qihong Zhao, Peng Li, Silvi A. Chacko, Arun Govindarajan, Robert M. Borzilleri, John S. Sack, Yeheng Zhu, Yunling Song, Dawn Sun, Anjuman Rudra, Mary T. Obermeier, Jinhong Wang, Douglas G. Batt, Venkata Murali
Publikováno v:
ACS Med Chem Lett
[Image: see text] Structure–activity relationship studies directed toward the replacement of the fused phenyl ring of the lead hexahydrobenzoindole RORγt inverse agonist series represented by 1 with heterocyclic moieties led to the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3296d470de82e26da82050921646783
https://doi.org/10.1021/acsmedchemlett.1c00112
https://doi.org/10.1021/acsmedchemlett.1c00112
Autor:
Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack
Publikováno v:
Journal of Medicinal Chemistry. 64:1454-1480
Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P1-5). The interaction of S1P with these S1P receptors has a fundamental role in many physiological processes in the vascular and immune systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c93ac373a666f79bb2e7b408fdbd2fc
https://doi.org/10.1021/acs.jmedchem.0c01109
https://doi.org/10.1021/acs.jmedchem.0c01109
Autor:
John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi
Publikováno v:
ACS Med Chem Lett
[Image: see text] Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P(1) differentiated modulators 3–6. The effects of analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fc075f357363f95afa2908797c5ae
https://doi.org/10.1021/acsmedchemlett.0c00333
https://doi.org/10.1021/acsmedchemlett.0c00333
Autor:
Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski
Publikováno v:
Journal of Medicinal Chemistry. 62:2265-2285
Recently, our research group reported the identification of BMS-986104 (2) as a differentiated S1P1 receptor modulator. In comparison to fingolimod (1), a full agonist of S1P1 currently marketed for the treatment of relapse remitting multiple scleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b124723f06570a19365c4eb5d204b0
https://doi.org/10.1021/acs.jmedchem.8b01695
https://doi.org/10.1021/acs.jmedchem.8b01695