Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Zilei Xia"'
Autor:
Chunlong Ma, Michael Dominic Sacco, Zilei Xia, George Lambrinidis, Julia Alma Townsend, Yanmei Hu, Xiangzhi Meng, Tommy Szeto, Mandy Ba, Xiujun Zhang, Maura Gongora, Fushun Zhang, Michael Thomas Marty, Yan Xiang, Antonios Kolocouris, Yu Chen, Jun Wang
Publikováno v:
ACS Central Science, Vol 7, Iss 7, Pp 1245-1260 (2021)
Externí odkaz:
https://doaj.org/article/bef2a55234da40e48cbb89c0d1d8e87c
Autor:
Haozhou Tan, Xiangzhi Meng, Maura V Gongora, Michael Dominic Sacco, Fushun Zhang, Yanmei Hu, Yan Xiang, Zilei Xia, Yu Chen, Juliana Choza, Janice Jang, Michael T. Marty, Chunlong Ma, Jun Wang, Julia Alma Townsend, Xiujun Zhang
Publikováno v:
Journal of the American Chemical Society
The main protease (Mpro) is a validated antiviral drug target of SARS-CoV-2. A number of Mpro inhibitors have now advanced to animal model study and human clinical trials. However, one issue yet to be addressed is the target selectivity over host pro
Autor:
Julia Alma Townsend, George Lambrinidis, Michael T. Marty, Yu Chen, Chunlong Ma, Maura V Gongora, Antonios Kolocouris, Jun Wang, Fushun Zhang, Yan Xiang, Zilei Xia, Xiujun Zhang, Xiangzhi Meng, Mandy Ba, Tommy Szeto, Michael Dominic Sacco, Yanmei Hu
Publikováno v:
ACS Central Science, Vol 7, Iss 7, Pp 1245-1260 (2021)
ACS Central Science
bioRxiv
article-version (status) pre
article-version (number) 1
ACS Central Science
bioRxiv
article-version (status) pre
article-version (number) 1
The papain-like protease (PLpro) of SARS-CoV-2 is a validated antiviral drug target. Through a fluorescence resonance energy transfer-based high-throughput screening and subsequent lead optimization, we identified several PLpro inhibitors including J
Autor:
Tommy Szeto, Michael Dominic Sacco, Xiangzhi Meng, Yu Chen, Yanmei Hu, Jun Wang, Fushun Zhang, Yan Xiang, Chunlong Ma, Zilei Xia
Publikováno v:
ACS Pharmacology & Translational Science
SARS-CoV-2 main protease (Mpro) is a cysteine protease that mediates the cleavage of viral polyproteins and is a validated antiviral drug target. Mpro is highly conserved among all seven human coronaviruses, with certain Mpro inhibitors having broad-
Publikováno v:
Chemical Communications. 53:7485-7488
An efficient approach for the synthesis of 2,2-disubstituted indolin-3-ones is described. From readily accessible aryl hydrazines and allyloxyketones, 2,2-disubstituted indolin-3-ones could be obtained in good to excellent yields under mild reaction
Autor:
William L. Robinson, Hiroaki Mitsuya, Yuki Takamatsu, Irene T. Weber, Daniel W. Kneller, Arun K. Ghosh, Megan E. Johnson, Satish Kovela, Zilei Xia, Manabu Aoki, Yuan-Fang Wang
Publikováno v:
ChemMedChem
We report here the synthesis and biological evaluation of phenylcarboxylic acid and phenylboronic acid containing HIV-1 protease inhibitors and their functional effect on enzyme inhibition and antiviral activity in MT-2 cell lines. Inhibitors bearing
Publikováno v:
RSC Advances. 5:38499-38502
The dienone-phenol rearrangement of 4,4-disubstituted cyclohexadienones catalyzed by Re2O7 has been described. Multi-substituted phenols can be efficiently obtained in good to excellent yields by employing this catalytic protocol.
Publikováno v:
RSC Adv.. 4:53397-53401
A novel oxidative rearrangement of malondialdehyde was described. Under the effect of H2O2, malondialdehyde smoothly transferred to carboxylic acid with C–C bond cleavage in good to excellent yields. Mechanistic studies showed that this reaction pr
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 3, Pp 949-957 (2022)
Metabolomics is an essential discipline in omics technology that promotes research on the biology of microbial systems. Streptomyces albus J1074 is a model organism used in fundamental research and industrial microbiology. Nevertheless, a comprehensi
Externí odkaz:
https://doaj.org/article/074c361f0c594840bb3aea002f6d74a2
Autor:
Qizheng Yao, Xiaolong Wan, Jiadong Hu, Weiqing Xie, Zhigao Shen, Zilei Xia, Yisheng Lai, Jin-Ming Gao
Publikováno v:
ChemInform. 47
Relying on the nucleophilicity of silanol for building up silicon-incorporated scaffold with an enantiopure tetrasubstituted carbon center remains elusive. In this report, asymmetric bromo-oxycyclization of olefinic silanol by using chiral anionic ph