Gold Nanoparticles as Boron Carriers for Boron Neutron Capture Therapy: Synthesis, Radiolabelling and In Vivo Evaluation

Autor: Pulagam, Krishna R., Gona, Kiran B., Gómez-Vallejo, Vanessa, Meijer, Jan, Zilberfain, Carolin, Estrela-Lopis, Irina, Baz, Zuriñe, Cossío, Unai, Llop, Jordi

Background: Boron Neutron Capture Therapy (BNCT) is a binary approach to cancer therapy that requires accumulation of boron atoms preferentially in tumour cells. This can be achieved by using nanoparticles as boron carriers and taking advantage of th

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Gold Nanoparticles as Boron Carriers for Boron Neutron Capture Therapy: Synthesis, Radiolabelling and In vivo Evaluation.

Autor: Pulagam KR; Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, 20014 San Sebastian, Spain. krpulagam@cicbiomagune.es., Gona KB; Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, 20014 San Sebastian, Spain. kirangonas@gmail.com.; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511, USA. kirangonas@gmail.com.; Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA. kirangonas@gmail.com., Gómez-Vallejo V; Radiochemistry Platform, CIC biomaGUNE, 20014, San Sebastian, Spain. vgomez@cicbiomagune.es., Meijer J; Institute of Medical Physics and Biophysics, Leipzig University, Härtelstrasse 16-18, 04107 Leipzig, Germany. jan.meijer@uni-leipzig.de., Zilberfain C; Felix Bloch Institute for Solid State Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany. Carolin.Merker@medizin.uni-leipzig.de., Estrela-Lopis I; Felix Bloch Institute for Solid State Physics, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany. Irina.Estrela-Lopis@medizin.uni-leipzig.de., Baz Z; Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, 20014 San Sebastian, Spain. zbaz@cicbiomagune.es., Cossío U; Radioimaging and Image Analysis Platform, CIC biomaGUNE, 20014 San Sebastian, Spain. ucossio@cicbiomagune.es., Llop J; Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, 20014 San Sebastian, Spain. jllop@cicbiomagune.es.; Centro de Investigación Biomédica en red Enfermedades Respiratorias-CIBERES, 28029 Madrid, Spain. jllop@cicbiomagune.es.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2019 Oct 07; Vol. 24 (19). Date of Electronic Publication: 2019 Oct 07.