Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zikou Liu"'
Autor:
Dominik F. Draxler, Gryselda Hanafi, Saffanah Zahra, Fiona McCutcheon, Heidi Ho, Charithani B. Keragala, Zikou Liu, David Daly, Thomas Painter, Sophia Wallace, Magdalena Plebanski, Paul S. Myles, Robert L. Medcalf
Publikováno v:
Thrombosis Journal, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Tranexamic acid (TXA) is an antifibrinolytic agent frequently used in elective surgery to reduce blood loss. We recently found it also acts as a potent immune-modulator in patients undergoing cardiac surgery. Methods Patients unde
Externí odkaz:
https://doaj.org/article/9acad31c0f7e4f36a4f5b7e6602bff63
Autor:
Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providin
Externí odkaz:
https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd
Autor:
Charithani B. Keragala, Trent M. Woodruff, Zikou Liu, Be'eri Niego, Heidi Ho, Zoe McQuilten, Robert L. Medcalf
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage. t-PA can also influence the CNS in pa
Externí odkaz:
https://doaj.org/article/e1ae5ef9386e4bcfa8235cdb4995d93e
Autor:
Wei Wang, Jinyang Cai, Yi Lin, Zikou Liu, Qihao Ren, Li Hu, Zan Huang, Mingxiong Guo, Wenxin Li
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92155 (2014)
Multiple nuclear localization domains have been identified in nuclear proteins, and they finely control nuclear import and functions of those proteins. ZNF268 is a typical KRAB-containing zinc finger protein (KRAB-ZFP), and previous studies have show
Externí odkaz:
https://doaj.org/article/7bd713fd6da04352ab7e998da1ec6051
Autor:
Cody C. Allison, Benjamin T. Kile, Esme C. Hatchell, Maria Kozlovskaia, Catriona McLean, Pradnya Gangatirkar, Gabriela Brumatti, Marc Pellegrini, Pamela A. McCombe, Julie Sheridan, Donald Metcalf, Klaus Warnatz, Natasha Silke, Maria C. Tanzer, Janelle E. Collinge, Seth L. Masters, Victoria E. Jackson, Jason Corbin, David B. Ascher, Dina Stockwell, Nicole Vlahovich, Zhixiu Li, James M. Murphy, Carola G. Vinuesa, Maria Kauppi, Ronald M. Laxer, John Reveille, Adrienne A. Hilton, John Silke, Ian J. Majewski, David Hughes, Gillian M. Tannahill, Melanie Bahlo, Christine Biben, Michael A. Silk, Maria A. Fiatarone Singh, Cathrine Hall, Peter E. Czabotar, Jian-Guo Zhang, Polly J. Ferguson, Sukhdeep K Spall, Carolyn A. de Graaf, Michael D. Stutz, Nils Venhoff, Alexander G. Bassuk, Zikou Liu, Holly Anderton, Michael S. Hildebrand, Tracy A. Willson, James A Rickard, Hiroyasu Nakano, Vicki Athanasopoulos, Matthew A. Brown, Samuel N. Young, Jens Thiel, Emma J. Petrie, Diep Chau, Sarah E Garnish, Sanae Miyake, Anne Tripaydonis, Warren S. Alexander, Allison Cox, Stefan Blum, Joanne M Hildebrand, Thomas S. Scerri, Kristin A Rigbye, Leila N. Varghese, Benjamin W. Darbro, Emma C. Josefsson, Ladina Di Rago
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, MlklD139V, that alters the two-helix ‘brace’ that connects the killer four-helix bundle and reg
Autor:
Dominik F. Draxler, Gryselda Hanafi, Saffanah Zahra, Fiona McCutcheon, Heidi Ho, Charithani B. Keragala, Zikou Liu, David Daly, Thomas Painter, Sophia Wallace, Magdalena Plebanski, Paul S. Myles, Robert L. Medcalf
Publikováno v:
Thrombosis journal. 20(1)
Background Tranexamic acid (TXA) is an antifibrinolytic agent frequently used in elective surgery to reduce blood loss. We recently found it also acts as a potent immune-modulator in patients undergoing cardiac surgery. Methods Patients undergoing lo
Autor:
Michelle Tang, Aleksandra Bankovacki, Samuel N. Young, Che A. Stafford, Sarah E Garnish, Joanne M Hildebrand, Ueli Nachbur, Cheree Fitzgibbon, Kristy Shield-Artin, John Silke, James M. Murphy, Zikou Liu, Jason Howitt, Andrew I. Webb, David Komander, Xiangyi Wang, Laura F. Dagley
Publikováno v:
EMBO J
Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomer
Autor:
Cheree Fitzgibbon, James M. Murphy, Jason Howitt, Samuel N. Young, Xiangyi Wang, Zikou Liu, Ueli Nachbur, Laura F. Dagley, David Komander, Michelle Tang, Aleksandra Bankovacki, Andrew I. Webb, Che A. Stafford, John Silke, Joanne M Hildebrand, Sarah E Garnish, Kristy Shield-Artin
Mixed lineage kinase domain-like (MLKL) is the executioner in the caspase-independent form of programmed cell death called necroptosis. Receptor Interacting serine/threonine Protein Kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff9e3cb7c2fc3ceb3bfc78d1147aeb38
https://doi.org/10.1101/2021.05.01.442209
https://doi.org/10.1101/2021.05.01.442209
Autor:
Be'eri Niego, Charithani B. Keragala, Trent M. Woodruff, Robert L. Medcalf, Zoe McQuilten, Zikou Liu, Heidi Ho
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 11 (2020)
Frontiers in Neurology, Vol 11 (2020)
Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage. t-PA can also influence the CNS in pa
Autor:
Robert L. Medcalf, Zikou Liu, Dominik F. Draxler, Heidi Ho, Maithili Sashindranath, Adam Galle, Maria Daglas
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 18(10)
Background Tranexamic acid (TXA) is an anti-fibrinolytic agent used to reduce bleeding in various conditions including traumatic brain injury (TBI). As the fibrinolytic system also influences the central nervous system and the immune response, TXA ma