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Akademický článek

A novel avian intestinal epithelial cell line: its characterization and exploration as an in vitro infection culture model for Eimeria species

Autor: Huifang Chen, Juan Li, Xiaoting Pan, Zhichao Hu, Jianfeng Cai, Zijie Xia, Nanshan Qi, Shenquan Liao, Zachary Spritzer, Yinshan Bai, Mingfei Sun

Publikováno v: Parasites & Vectors, Vol 17, Iss 1, Pp 1-17 (2024)

Abstract Background The gastrointestinal epithelium plays an important role in directing recognition by the immune system, and epithelial cells provide the host's front line of defense against microorganisms. However, it is difficult to cultivate avi

Externí odkaz: https://doaj.org/article/a364df52d3bd40fb803f3e0298c51520

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Akademický článek

Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses

Autor: Silu Deng, Wei He, Ai-Yu Gong, Min Li, Yang Wang, Zijie Xia, Xin-Tiang Zhang, Andrew S. Huang Pacheco, Ankur Naqib, Mark Jenkins, Patrick C. Swanson, Kristen M. Drescher, Juliane K. Strauss-Soukup, Michael Belshan, Xian-Ming Chen

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Cryptosporidium parvum virus 1 is a virus harbored by the pathogenic protozoan Cryptosporidium parvum, and whose role in parasite biology and host interactions remains unclear. Here, Deng et al. demonstrate the impact this virus has on host response

Externí odkaz: https://doaj.org/article/9b1e06c8f71d4bc8939f5c194e11c17d

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Akademický článek

Bimetallic Flower-like NiCoP Encapsulated in an N-Doped Carbon Shell with Enhanced Lithium Storage Properties

Autor: Haoyu Tian, Lingyu Zhao, Linlin Wang, Zijie Xia, Wenqi Tan, Zheng Jiao

Publikováno v: Batteries, Vol 9, Iss 7, p 361 (2023)

It continues to be a challenge to design innovative NiCoP composite anode materials to further improve rate capacity. In this work, bimetallic flower-like NiCoP encapsulated in an N-doped carbon shell (designated as NiCoP@NC) as a high-rate capable a

Externí odkaz: https://doaj.org/article/12ef94e65c7e458ea7aa58a736f105c0

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Akademický článek

m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection

Autor: Zijie Xia, Jihao Xu, Eugene Lu, Wei He, Silu Deng, Ai-Yu Gong, Juliane Strass-Soukup, Gislaine A. Martins, Guoqing Lu, Xian-Ming Chen

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Increasing evidence supports that N6-methyladenosine (m6A) mRNA modification may play an important role in regulating immune responses. Intestinal epithelial cells orchestrate gastrointestinal mucosal innate defense to microbial infection, but underl

Externí odkaz: https://doaj.org/article/49b7356a2d00468b9b3cd7da134ec019

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Akademický článek

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Autor: Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia, Young Kwang Lee, Serena Muratcioglu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams, John Kuriyan

Publikováno v: eLife, Vol 9 (2020)

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an oligomeric enzyme with crucial roles in neuronal signaling and cardiac function. Previously, we showed that activation of CaMKII triggers the exchange of subunits between holoenzymes, potenti

Externí odkaz: https://doaj.org/article/811a46346e94491a8a20e6b13f51505a

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