Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Zihua Xu"'
Autor:
Siyuan Liu, Xinzhu Li, Panpan Fan, Yujia Gu, Aizhu Yang, Weiyi Wang, Lijun Zhou, Huanhua Chen, Fangyuan Zheng, Junjie Lin, Zihua Xu, Qingchun Zhao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117575- (2024)
Sterol regulatory element binding proteins (SREBPs) are a series of cholesterol-related transcription factors. Their role in regulating brain cholesterol biosynthesis, amyloid accumulation, and tau tangles formation has been intensively studied in pr
Externí odkaz:
https://doaj.org/article/5bdceb8aaeab4d75820bf7c6a86e2a76
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Introduction: ZLDI-8, which has a relatively strong antitumor activity, is an inhibitor of ADAM-17 and acts on the Notch signaling pathway. To further optimize its structure and improve its activity, a series of derivatives of ZLDI-8 was synthesized.
Externí odkaz:
https://doaj.org/article/e5838f1c6c5b4796b4de14671db3aa62
Autor:
Tianshu Ren, Hui Jia, Qiong Wu, Yan Zhang, Qun Ma, Dong Yao, Xudong Gao, Danni Xie, Zihua Xu, Qingchun Zhao, Yingshi Zhang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Bevacizumab (Bev) is a humanized vascular endothelial growth factor monoclonal antibody that is used with chemotherapeutic drugs for the treatment of metastatic colorectal cancer (mCRC). Bev-induced hypertension (HT) is the most common adverse reacti
Externí odkaz:
https://doaj.org/article/a9be20ef6f484508970e657a911f252a
Autor:
Xiaowen Jiang, Hongyuan Lu, Wenwu Liu, Zhongchan Wu, Qiong Wu, Xiang Li, Zihua Xu, Fuhai Hui, Qingchun Zhao
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 5, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/1be32218265a427291f93c03f5172f67
Autor:
Xiaowen Jiang, Hongyuan Lu, Jingda Li, Wenwu Liu, Qiong Wu, Zihua Xu, Qinglong Qiao, Haotian Zhang, Huiyuan Gao, Qingchun Zhao
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 3, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/cfc885bdac104ee696e03859d1b490fd
Publikováno v:
Molecules, Vol 20, Iss 3, Pp 4319-4336 (2015)
A high-throughput, sensitive and specific LC-ESI-MS/MS method was established for the quantitative determination of GP205, a potent inhibitor of hepatitis C virus NS3/4A protease, in rat. The analyte was isolated from 25 μL plasma sample by 96-well
Externí odkaz:
https://doaj.org/article/f7a795bccf2346a9bcc07e1f6e782eaa
Autor:
Bo Xing, Yaling Cui, Ying Chen, Lingyun Lai, Meiling Zhang, Xiangbo Xu, Nan Wang, Xiaowen Jiang, Zihua Xu, Qingchun Zhao
Publikováno v:
Evidence-Based Complementary and Alternative Medicine. 2022:1-14
Background. Keyin pill (KP), a patented medicine in China, is used to treat psoriasis. However, KP has been reported to have liver toxicity, but its toxic substance basis and underlying mechanisms remain unclear. Therefore, this study aimed to explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546221c2f00d82128b7c3fc2bea7c5a6
https://doi.org/10.1155/2022/9916949
https://doi.org/10.1155/2022/9916949
Autor:
Nan Wang, Wenjie Liu, Lijun Zhou, Wenwu Liu, Xu Liang, Xin Liu, Zihua Xu, Tianming Zhong, Qiong Wu, Xinming Jiao, Jiangxia Chen, Xinyue Ning, Xiaowen Jiang, Qingchun Zhao
Publikováno v:
ACS Omega. 7:32131-32152
The pathogenesis of Alzheimer's disease (AD) is very complex, and there are many hypotheses. Therefore, the development of a multi-target-directed-ligand may be an effective therapeutic strategy. Our previous study showed that notopterol (a natural p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e114409e93679c4eb4684f085c3c8ba
https://doi.org/10.1021/acsomega.2c03368
https://doi.org/10.1021/acsomega.2c03368
Publikováno v:
New Journal of Chemistry. 46:19342-19356
Novel tacrine derivative ZLWT-48 possessed potent CDK9 inhibition activity (8.639 nM) and good selectivity over CDK2 (SI > 57).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b4e5276320fc84dc1bd5f514c19b86
https://doi.org/10.1039/d2nj03667c
https://doi.org/10.1039/d2nj03667c
Autor:
Lijun Zhou, Nan Wang, Wenzheng Feng, Xin Liu, Zihua Xu, Qiong Wu, Jiangxia Chen, Xinming Jiao, Xinyue Ning, Zhentong Qi, Xiaowen Jiang, Qingchun Zhao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::480ce74848ae23507e016806d0779e8f
https://doi.org/10.2139/ssrn.4447576
https://doi.org/10.2139/ssrn.4447576
