Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Zihao Mai"'
Autor:
Hongce Chen, Beini Sun, Han Sun, Lingjun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xuhong Fan, Zihao Mai, Qiling Tang, Xiaoping Wang, Tongsheng Chen
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Metformin (Met) exhibits anticancer ability in various cancer cell lines. This report aims to explore the exact molecular mechanism of Met-induced apoptosis in HCT116 cells, a human colorectal cancer cell line. Met-induced reactive oxygen sp
Externí odkaz:
https://doaj.org/article/ec5ff3f3032d4cd888f7caf48a7b9838
Autor:
Yunyun Ma, Mengyan Du, Fangfang Yang, Zihao Mai, Chenshuang Zhang, Wenfeng Qu, Bin Wang, Xiaoping Wang, Tongsheng Chen
Publikováno v:
FEBS Open Bio, Vol 9, Iss 12, Pp 2041-2051 (2019)
Mitochondrial fission regulates mitochondrial function and morphology, and has been linked to apoptosis. The mitochondrial fission factor (Mff), a tail‐anchored membrane protein, induces excessive mitochondrial fission, contributing to mitochondria
Externí odkaz:
https://doaj.org/article/4a358e109d6442d297407c5c4d90973c
Publikováno v:
Royal Society Open Science, Vol 4, Iss 10 (2017)
We recently developed a polyethylenimine (PEI) and polyethylene glycol (PEG) dual-functionalized reduced graphene oxide (GO) (PEG−nrGO−PEI, RGPP) for high-efficient gene delivery in HepG2 and Hela cell lines. To evaluate the feasibility and appli
Externí odkaz:
https://doaj.org/article/a421d48306d04d33b7e7e2702124db0f
Publikováno v:
Biochemical and Biophysical Research Communications. 639:91-99
The Transmembrane Carboxyl Terminal Domain (TMD) of some Bcl-2 family proteins has been demonstrated to play a key role in modulating apoptosis. We here ustilzed live-cell fluorescence imaging to evaluate how the Bcl-xL TMD (XT) regulate apoptosis. C
Autor:
Zihao Mai, Han Sun, Fangfang Yang, Mengyan Du, Xuecheng Cheng, Hongce Chen, Beini Sun, Junlin Wen, Xiaoping Wang, Tongsheng Chen
Publikováno v:
The international journal of biochemistrycell biology.
Although Bcl-xL has been shown to retrotranslocate Bax from mitochondria to cytosol, other studies have found that Bcl-xL also stabilizes the mitochondrial localization of Bax. It is still unclear what causes the difference in Bcl-xL-regulated Bax lo
Autor:
Han Sun, Ling-Jun Xu, Gui-Hao Wu, Beini Sun, Xiaoping Wang, Xuecheng Cheng, Xuhong Fan, Tongsheng Chen, Zhuang Tu, Zihao Mai, Qiling Tang, Hongce Chen
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Cell Death Discovery
Cell Death Discovery
Metformin (Met) exhibits anticancer ability in various cancer cell lines. This report aims to explore the exact molecular mechanism of Met-induced apoptosis in HCT116 cells, a human colorectal cancer cell line. Met-induced reactive oxygen species (RO
Autor:
Qiling Tang, Hongce Chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang, Tongsheng Chen
Publikováno v:
Free radical biologymedicine. 180
Abivertinib (AC) is a novel epidermal growth factor receptor tyrosine kinase inhibitor with highly efficient antitumor activity. Here, we report the capacity of AC to induce both reactive oxygen species (ROS)-dependent apoptosis and ferroptosis in tu
Publikováno v:
Apoptosis. 24:758-772
In contrast to the well-known anti-tumor mechanisms of aspirin in inducing apoptosis or autophagy, we here for the first time report oncosis induced by aspirin in tumor cells. In vitro and in vivo analysis showed that aspirin induced compromised Bcl-
Autor:
Miao Chen, Zhenhao Liang, Guanling Zeng, Yu Wang, Zihao Mai, Xiaoyu Chen, Ge Wu, Tongsheng Chen
Publikováno v:
Dyes and Pigments. 198:109995
Publikováno v:
Biochemical and biophysical research communications. 527(4)
We here used fluorescence imaging to explore the effect of co-overexpression of Mcl-1 and Bak/BH3-only proteins on mitochondrial morphology. The cells co-expressing CFP-Mcl-1 and YFP-Bak/BimL/Puma/tBid showed co-localization of Mcl-1 with Bak/Puma/Bi