Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Zihan Lei"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 7, Pp 941-952 (2023)
Abstract PB‐201 is the second glucokinase activator in the world to enter the phase III clinical trials for the treatment of type 2 diabetes mellitus (T2DM). Combined with the efficacy advantages and the friendly absorption, distribution, metabolis
Externí odkaz:
https://doaj.org/article/60a8b0590f474b579c7da6d4ea2ca4cb
Autor:
Zhiheng Yu, Zihan Lei, Xueting Yao, Hengbang Wang, Miao Zhang, Zhe Hou, Yafen Li, Yangyu Zhao, Haiyan Li, Dongyang Liu, Yifan Zhai
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Olverembatinib (HQP1351) is a third-generation BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML) (including T315I-mutant disease), exhibits drug-drug interaction (DDI) potential through cytochrome P450 (CYP) enzyme
Externí odkaz:
https://doaj.org/article/e057d585033c46888bfd0927e6e519e0
Autor:
Miao Zhang, Zhiheng Yu, Xueting Yao, Zihan Lei, Kaijing Zhao, Wenqian Wang, Xue Zhang, Xijing Chen, Dongyang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo. Meanwhile, genotype is a key factor affecting pyrotinib cl
Externí odkaz:
https://doaj.org/article/be6fa8d0ddde4b4daa35e428b0069e02
Autor:
Xueting Yao, Xuanlin Liu, Siqi Tu, Xiaobei Li, Zihan Lei, Zhe Hou, Zhiheng Yu, Cheng Cui, Zhongqi Dong, Farzaneh Salem, Haiyan Li, Dongyang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Physiologically based pharmacokinetic (PBPK) modeling and simulating may be a powerful tool in predicting drug behaviors in specific populations. It is a mathematical model that relates the pharmacokinetic (PK) profile of a compound with
Externí odkaz:
https://doaj.org/article/7f8cafbf6910436a899623145d790cbd
Autor:
Miao Zhang, Xueting Yao, Zhe Hou, Xuan Guo, Siqi Tu, Zihan Lei, Zhiheng Yu, Xuanlin Liu, Cheng Cui, Xijing Chen, Ning Shen, Chunli Song, Jie Qiao, Xiaoqiang Xiang, Haiyan Li, Dongyang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
In Feb 2020, we developed a physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine (HCQ) and integrated in vitro anti-viral effect to support dosing design of HCQ in the treatment of COVID-19 patients in China. This, along with emer
Externí odkaz:
https://doaj.org/article/7326eb28589e4d25b9188bbe43d1b44a
Publikováno v:
Electronics Letters (Wiley-Blackwell); Jan2024, Vol. 60 Issue 1, p1-4, 4p
Autor:
Yaya Yang, Haixia Zhang, Xiaolei Lan, Xianhui Qin, Yan Huang, Jieyu Wang, Pei Luo, Zhen Wen, Yumin Li, Yaozhong Kong, Qijun Wan, Qi Wang, Sheng Huang, Yan Liu, Aiqun Liu, Fanna Liu, Shenglin Yang, Yongxin Lu, Yanhong Zhao, Junzhi Chen, Zihan Lei, Yanhuan He, Zizhen Lin, Youbao Li, Min Liang
Publikováno v:
Clinical Kidney Journal. 16:167-175
Background Data are limited on the relationship between waist-to-hip ratio (WHR) and mortality risk among maintenance hemodialysis (MHD) patients. Moreover, the combined association of body mass index (BMI) and WHR with mortality remains uncertain. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f96625192168d2ca54763d7c6f7664
https://doi.org/10.1093/ckj/sfac210
https://doi.org/10.1093/ckj/sfac210
Autor:
Yan Huang, Yanhuan He, Huiqin Tao, Yaozhong Kong, Xianhui Qin, Min Liang, Qijun Wan, Aiqun Liu, Qi Wang, Yaya Yang, Junzhi Chen, Youbao Li, Zihan Lei, Zizhen Lin
Publikováno v:
Clinical Journal of the American Society of Nephrology. 16:1228-1236
Background and objectives Fat-based energy-dense nutritional supplements may offer benefits over protein- or carbohydrate-dense supplements for patients receiving dialysis because of the adverse metabolic consequences of the latter. We conducted a ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04529e10311ac3fd738c5f2fdd143bec
https://doi.org/10.2215/cjn.16821020
https://doi.org/10.2215/cjn.16821020
Autor:
Xuan Guo, Lei Zhang, Zihan Lei, Zhe Hou, Hui Li, Xiaodong Li, Jing Dong, Ling Song, Dingding Chen, Dongyang Liu
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1214
The aim of this study is to develop a LC-MS/MS method for the quantitation of seven cytochrome P450 (CYP450) enzymes.A high-performance liquid chromatography-tandem mass spectrometry method was developed using multiple reaction monitoring mode with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e7c3cbb91f6ec673206b3e31479517
https://pubmed.ncbi.nlm.nih.gov/36473299
https://pubmed.ncbi.nlm.nih.gov/36473299
Autor:
Yanyan Su, Jiaqi Xu, Siqi Chen, Junxia Feng, Jingchun Li, Zihan Lei, Lingyan Qiao, Yaning Wang, Dewang Zeng
Publikováno v:
Translational andrology and urology. 11(8)
This study sought to investigate the protective effects of Astragaloside IV (AS-IV) on ischemia-reperfusion (I/R) renal injury based on the keap1-Nrf2/ARE signaling pathway.A total of 36 male Sprague-Dawley rats (aged: 8 weeks; weighing: 200-220 g) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc18804397cbaf18cd0166692e634e2
https://pubmed.ncbi.nlm.nih.gov/36092836
https://pubmed.ncbi.nlm.nih.gov/36092836