Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Zihai Li"'
Autor:
Yuzhou Chang, Jixin Liu, Yi Jiang, Anjun Ma, Yao Yu Yeo, Qi Guo, Megan McNutt, Jordan E. Krull, Scott J. Rodig, Dan H. Barouch, Garry P. Nolan, Dong Xu, Sizun Jiang, Zihai Li, Bingqiang Liu, Qin Ma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Spatial omics technologies decipher functional components of complex organs at cellular and subcellular resolutions. We introduce Spatial Graph Fourier Transform (SpaGFT) and apply graph signal processing to a wide range of spatial omics pro
Externí odkaz:
https://doaj.org/article/41ab4e48d4e6480da1c0f949ca4779ee
Autor:
Jianwen Chen, Bao Zhao, Hong Dong, Tianliang Li, Xiang Cheng, Wang Gong, Jing Wang, Junran Zhang, Gang Xin, Yanbao Yu, Yu L Lei, Jennifer D Black, Zihai Li, Haitao Wen
Publikováno v:
eLife, Vol 13 (2024)
The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and O-GlcNAcylation levels in a
Externí odkaz:
https://doaj.org/article/e8c076eebdab41c1be6de9e8394316f4
Autor:
Do-Sung Kim, Lili Song, Wenyu Gou, Jisun Kim, Bei Liu, Hua Wei, Robin C. Muise-Helmericks, Zihai Li, Hongjun Wang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-12 (2024)
Abstract High workload-induced cellular stress can cause pancreatic islet β cell death and dysfunction, or β cell failure, a hallmark of type 2 diabetes mellitus. Thus, activation of molecular chaperones and other stress-response genes prevents β
Externí odkaz:
https://doaj.org/article/da3d8bce9a954de4856020c5ba9dd6a1
Autor:
Po-Lan Su, Karthik Chakravarthy, Naoki Furuya, Jeremy Brownstein, Jianhua Yu, Meixiao Long, David Carbone, Zihai Li, Kai He
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-5 (2024)
Abstract DLL3 acts as an inhibitory ligand that downregulates Notch signaling and is upregulated by ASCL1, a transcription factor prevalent in the small-cell lung cancer (SCLC) subtype SCLC-A. Currently, the therapeutic strategies targeting DLL3 are
Externí odkaz:
https://doaj.org/article/d10fc426c38f4600bcf76fa725a89e1b
Autor:
Juan Xie, Kyeong Joo Jung, Carter Allen, Yuzhou Chang, Subhadeep Paul, Zihai Li, Qin Ma, Dongjun Chung
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 10 (2024)
IntroductionThe advent of high throughput spatial transcriptomics (HST) has allowed for unprecedented characterization of spatially distinct cell communities within a tissue sample. While a wide range of computational tools exist for detecting cell c
Externí odkaz:
https://doaj.org/article/dcf9483cfe944eee8fd28f6e75addad5
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The maturation process of natural killer (NK) cells, which is regulated by multiple transcription factors, determines their functionality, but few checkpoints specifically targeting this process have been thoroughly studied. Here we show tha
Externí odkaz:
https://doaj.org/article/d7022c7c3b98461799f094d172b0bc86
Autor:
Xiaoying Wang, Maoteng Duan, Jingxian Li, Anjun Ma, Gang Xin, Dong Xu, Zihai Li, Bingqiang Liu, Qin Ma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Rare cell populations are key in neoplastic progression and therapeutic response, offering potential intervention targets. However, their computational identification and analysis often lag behind major cell types. To fill this gap, we intro
Externí odkaz:
https://doaj.org/article/65356025a01e4df8b30bca9b8c924629
Autor:
Hyunwoo Kwon, Mingjia Li, Jesse D Sheldon, Nicholas Jones, Nicolas Gallastegui Crestani, Zihai Li, Dwight H Owen
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 13, Iss , Pp 100275- (2024)
Background: Hypereosinophilia, as defined by the absolute eosinophil count ≥ 1,500 cells per microliter, can be a consequence of primary (clonal) hematologic disorders or secondary response to inflammation from allergens, parasitic infections, medi
Externí odkaz:
https://doaj.org/article/63b3ae364f6a47d482bab0d6b931a119
Autor:
Dan H Barouch, Yi Wang, Mark P Rubinstein, Zihai Li, Anqi Li, Sarah Reisinger, Peter G Shields, Qin Ma, No-Joon Song, Dongjun Chung, Karthik B Chakravarthy, Chelsea Bolyard, Hyeongseon Jeon, Kelsi Reynolds, Kevin P Weller, Sizun Jiang, Eugene M Oltz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is highly transmissible and evades pre-established immunity. Messenger RNA (mRNA) vaccination against ancestral strain spike protein can induce intact T-cell
Externí odkaz:
https://doaj.org/article/a52a3aaab70c4bc4b814b6816e637492
Autor:
Zihai Li, Yuanquan Yang, Amir Mortazavi, Mingjia Li, Daniel Spakowicz, Komal Das, Jayajit Das, Giuseppe Giuliani, Anil Parwani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/18668a75766a496696a1fcb19c01e7c6