Rhamnetin Prevents Bradykinin-Induced Expression of Matrix Metalloproteinase-9 in Rat Brain Astrocytes by Suppressing Protein Kinase-Dependent AP-1 Activation

Autor: Chuen-Mao Yang, I-Ta Lee, Li-Der Hsiao, Zih-Yao Yu, Chien-Chung Yang

Publikováno v: Biomedicines, Vol 11, Iss 12, p 3198 (2023)

Bradykinin (BK) has been recognized as a stimulant for matrix metalloproteinase (MMP)-9 expression, contributing to neuroinflammation. Modulating the BK/MMP-9 pathway offers potential in the treatment of neuroinflammatory disorders. Rhamnetin (RNT),

Externí odkaz: https://doaj.org/article/05cb1b020fbc4db58b39a1d215b9f181

Anti-Inflammatory Effects of Rhamnetin on Bradykinin-Induced Matrix Metalloproteinase-9 Expression and Cell Migration in Rat Brain Astrocytes

Autor: Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Zih-Yao Yu, Chuen-Mao Yang

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 609
International Journal of Molecular Sciences, Vol 23, Iss 609, p 609 (2022)
International Journal of Molecular Sciences

Bradykinin (BK) has been shown to induce matrix metalloproteinase (MMP)-9 expression and participate in neuroinflammation. The BK/MMP-9 axis can be a target for managing neuroinflammation. Our previous reports have indicated that reactive oxygen spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8608ed9ef52f33b54e071f4eacf159d
https://doi.org/10.3390/ijms23020609

Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models.

Autor: Ting-Yu Chang¹, Yan Yan², Zih-Yao Yu¹, Rathore, Moeez^2,3, Nian-Zhe Lee¹, Hui-Ju Tseng¹, Li-Hsin Cheng^4,5, Wei-Jan Huang⁶, Wei Zhang^2,3, Chan, Ernest R.⁷, Yulan Qing², Ming-Lun Kang⁸, Rui Wang^2,3, Tsai, Kelvin K.^4,5, Pink, John J.², Harte, William E.⁹, Gerson, Stanton L.^2,10 slg5@case.edu, Sung-Bau Lee¹ sbl@tmu.edu.tw

Publikováno v: Journal of Clinical Investigation. 12/2/2024, Vol. 134 Issue 23, p1-17. 17p.