Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zifang Deng"'
Autor:
Zifang Deng, Fenfei Leng
Publikováno v:
ACS Omega, Vol 6, Iss 18, Pp 12205-12212 (2021)
Externí odkaz:
https://doaj.org/article/61fe109254424e43bfd75503a7b7689e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3710 (2020)
The mammalian high-mobility-group protein AT-hook 2 (HMGA2) is a small DNA-binding protein and consists of three “AT-hook” DNA-binding motifs and a negatively charged C-terminal motif. It is a multifunctional nuclear protein directly linked to ob
Externí odkaz:
https://doaj.org/article/06a8df2dfdc547acad05ad63ea0c1586
Autor:
Eddy E. Alfonso, Zifang Deng, Daniel Boaretto, Becky L. Hood, Stefan Vasile, Layton H. Smith, Jeremy W. Chambers, Prem Chapagain, Fenfei Leng
Publikováno v:
ACS Pharmacology & Translational Science. 5:932-944
Bacterial DNA gyrase, a type IIA DNA topoisomerase that plays an essential role in bacterial DNA replication and transcription, is a clinically validated target for discovering and developing new antibiotics. In this article, based on a supercoiling-
Publikováno v:
Journal of Biological Chemistry. Dec2023, Vol. 299 Issue 12, p1-11. 11p.
Autor:
Eddy E. Alfonso, Rogelio Troche, Zifang Deng, Thirunavukkarasu Annamalai, Prem Chapagain, Yuk‐Ching Tse‐Dinh, Fenfei Leng
Publikováno v:
ChemMedChem. 17(23)
Bacterial DNA gyrase, an essential enzyme, is a validated target for discovering and developing new antibiotics. Here we screened a pool of polyphenols and discovered that digallic acid is a potent DNA gyrase inhibitor. We also found that several foo
Autor:
Fenfei Leng, Zifang Deng
Publikováno v:
ACS Omega, Vol 6, Iss 18, Pp 12205-12212 (2021)
ACS Omega
ACS Omega
DNA topoisomerases, essential enzymes to all living organisms, are important targets of certain antibiotics and anticancer drugs. Although efforts have been taken to identify new inhibitors targeting DNA topoisomerases, limited high throughput screen
Publikováno v:
Biophysical Journal. 121:348a