Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ziegler, Carl B."'
Autor:
Chao Li, Rod Stevens, Jason K. Dutra, Annette M. Silvia, Michelle L. Haven, Scott B. Seibel, Erik L. Nimz, Ziegler Carl B, Kristin M. Lundy DeMello, Robert J. Rafka, Cheng Hengmiao, Martha L. Minich, Jin Li, Nicole L. Kolosko, Carol F. Petras, Subas M. Sakya, Donald W. Mann, Kazuo Ando, K. Kawamura, Carolyn Rose Kilroy, Lisa A. Lund, Burton H. Jaynes, Tomoki Kato
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2076-2080
The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure–activity relationship (SAR) studies of this class of compounds led to the identification of compound 1 which demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096af07029de50fcfe74128b57b3a069
https://doi.org/10.1016/j.bmcl.2006.01.059
https://doi.org/10.1016/j.bmcl.2006.01.059
Autor:
Suzanne H. St. Denis, Michelle L. Haven, Scott B. Seibel, Carol F. Petras, Subas M. Sakya, Lisa A. Lund, Annette M. Silvia, Michael P. Lynch, Bryson Rast, Cheng Hengmiao, Martha L. Minich, Burton H. Jaynes, Kristin M. Lundy DeMello, Donald W. Mann, Andrei Shavnya, Anne Hickman, Ziegler Carl B, David A. Koss, David M. George, Robert J. Rafka, Jin Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:288-292
Structure-activity relationship (SAR) studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-yl]-5-methanesulfonyl (SO(2)Me)/sulfamoyl (SO(2)NH(2))-pyridine derivatives for canine COX enzymes are described. The studies led to the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287d246c2a3746f106e9752c3bac59e
https://doi.org/10.1016/j.bmcl.2005.10.006
https://doi.org/10.1016/j.bmcl.2005.10.006
Autor:
Rhonda M. Crosson, David A. Koss, Michelle L. Haven, Carolyn Rose Kilroy, Martha L. Minich, Robert J. Rafka, Eric L. Nimz, Morton Barry James, Scott B. Seibel, Lisa A. Lund, Carol F. Petras, Kristin M. Lundy DeMello, Chao Li, Annette M. Silvia, Bryson Rast, Kathleen M. Callaghan, Andrei Shavnya, Michael P. Lynch, Subas M. Sakya, Ziegler Carl B, Jin Li, Nicole L. Kolosko, Bronk Brian Scott, Donald W. Mann, Jason K. Dutra, Burton H. Jaynes, Henry Cheng, Glen W. Kirk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:95-98
Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f71036c4dab955ec24afc57075467a
https://doi.org/10.1016/j.bmcl.2003.10.004
https://doi.org/10.1016/j.bmcl.2003.10.004
Autor:
Ziegler Carl B, John P. Dirlam, Thomas N. O'Connell, Barbara J. Kamicker, David M. George, Sheryl L. Santoro, Subas M. Sakya, Melani Suarez-Contreras, Shigeru F. Hayashi
Publikováno v:
ChemInform. 33
3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b1388538d4089372b8549fd7ab6cdd4
https://doi.org/10.1002/chin.200204237
https://doi.org/10.1002/chin.200204237
Autor:
Ziegler Carl B
Publikováno v:
The Journal of Organic Chemistry. 55:2983-2986
Synthese d'isopropyl-3 methyl-1 propynyl-2 cyclopentene a partir de bromure de dibromo-2,3 butene-2 yl triphenyl phosphonium et de methyl-6 heptene-5 one-2 via un halo [3] cumulene (bromo-2 dimethyl-5,9 decatetraene-2,3,4,8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681a5d77c06c365200653d1252e7a98d
https://doi.org/10.1021/jo00296a085
https://doi.org/10.1021/jo00296a085
Autor:
David A. Koss, Cheng Hengmiao, Martha L. Minich, Robert J. Rafka, Ziegler Carl B, Anne Hickman, Jason K. Dutra, Annette M. Silvia, Jin Li, Michael P. Lynch, Chao Li, Andrei Shavnya, Michelle L. Haven, Scott B. Seibel, Bryson Rast, David M. George, Kristin M. Lundy DeMello, Donald W. Mann, Burton H. Jaynes, Carol F. Petras, Subas M. Sakya
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
Structure-activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine COX enzymes are described. The 4-cyano-5-alkyl ethers were found to have excellent potency a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c1d7a31ee47ce7d3e43437166665af
https://pubmed.ncbi.nlm.nih.gov/16380252
https://pubmed.ncbi.nlm.nih.gov/16380252
Autor:
Sheryl L. Santoro, Cheng Hengmiao, Martha L. Minich, Peter Bertinato, Subas M. Sakya, Melani Suarez-Contreras, Bryan Pratt, Camilla D. Bertsche, Shigeru F. Hayashi, David M. George, Barbara J. Kamicker, Kristin Marie Lundy, Ziegler Carl B
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(7)
Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity against veterinary pathogens, including Staphylococcus aureus and Pasteurella multocida.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caacad70d869e31f2ce5a22d2adfb70
https://pubmed.ncbi.nlm.nih.gov/12657285
https://pubmed.ncbi.nlm.nih.gov/12657285
Autor:
Barbara J. Kamicker, Thomas N. O'Connell, Sheryl L. Santoro, Subas M. Sakya, Shigeru F. Hayashi, Melani Suarez-Contreras, John P. Dirlam, David M. George, Ziegler Carl B
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(20)
3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3265ef32bb778633e9884c83bead60
https://pubmed.ncbi.nlm.nih.gov/11591516
https://pubmed.ncbi.nlm.nih.gov/11591516
Autor:
Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2006 16(8):2076-2080
Autor:
Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2006 16(5):1202-1206