Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

Autor: Gurzeler, Lukas-Adrian, Link, Marion, Ibig, Yvonne, Schmidt, Isabel, Galuba, Olaf, Schoenbett, Julian, Gasser-Didierlaurant, Christelle, Parker, Christian N., Mao, Xiaohong, Bitsch, Francis, Schirle, Markus, Couttet, Philipp, Sigoillot, Frederic, Ziegelmüller, Jana, Uldry, Anne-Christine, Teodorowicz, Wojciech, Schmiedeberg, Niko, Mühlemann, Oliver, Reinhardt, Jürgen

Publikováno v: In Cell Reports 26 September 2023 42(9)

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Universal features of Nsp1-mediated translational shutdown by coronaviruses.

Autor: Schubert K; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Karousis ED; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.; Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland., Ban I; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Lapointe CP; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Leibundgut M; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Bäumlin E; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.; Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland., Kummerant E; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Scaiola A; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Schönhut T; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Ziegelmüller J; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Puglisi JD; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Mühlemann O; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Ban N; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 01. Date of Electronic Publication: 2023 Jun 01.