Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Zichun, Hua"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
BackgroundCharacterized by an immune-suppressive tumor microenvironment (TME), pancreatic ductal adenocarcinoma (PDAC) is well-known for its poor prognosis. Tumor associated macrophages (TAMs) play a critical role in PDAC TME. An in-depth understandi
Externí odkaz:
https://doaj.org/article/e069c82a8b3c4e9abbf5f477fc9966f4
Autor:
Leyang Wu, Lin Li, Liyuan Qiao, Chenyang Li, Shuhui Zhang, Xingpeng Yin, Zengzheng Du, Ying Sun, Jiahui Qiu, Xiaoyao Chang, Bohao Wang, Zichun Hua
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Engineered bacteria‐mediated antitumor approaches have been proposed as promising immunotherapies for cancer. However, the off‐target bacterial toxicity narrows the therapeutic window. Living microbes will benefit from their controllable
Externí odkaz:
https://doaj.org/article/4a42b163a42e493f8e3a5541375d5bc1
Publikováno v:
Journal of Big Data, Vol 11, Iss 1, Pp 1-20 (2024)
Abstract Background The recruitment of thermogenic adipocytes in human fat depots markedly improves metabolic disorders such as type 2 diabetes mellitus (T2DM). However, identification and quantification of thermogenic cells in human fats, especially
Externí odkaz:
https://doaj.org/article/70550d9ab438430e859239282aea99aa
Autor:
Leyang Wu, Zengzheng Du, Lin Li, Liyuan Qiao, Shuhui Zhang, Xingpeng Yin, Xiaoyao Chang, Chenyang Li, Zichun Hua
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Live bacteria-mediated antitumor therapies mark a pivotal point in cancer immunotherapy. However, the difficulty in reconciling the safety and efficacy of bacterial therapies has limited their application. Improving bacterial tumor-targeted
Externí odkaz:
https://doaj.org/article/aab63e6643b1440d8566f7dd68bd46bc
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109372- (2024)
Summary: In the tumor microenvironment (TME), tumor-associated NEs (TANs) have the potential to be protumorigenic or antitumorigenic within the TME in response to environmental cues. The diversity and plasticity of NEs (NEs) underlie the dual potenti
Externí odkaz:
https://doaj.org/article/d647dce6e7b340eba07a7b19dbe8a2e5
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/ebfcdc4596d948d282a34210e4338700
Autor:
Yanguan Guo, Jiaxin Tian, Yongjian Guo, Cong Wang, Congcong Chen, Songwang Cai, Wenliang Yu, Binghe Sun, Jin Yan, Zhonghua Li, Jun Fan, Qi Qi, Dongmei Zhang, Weilin Jin, Zichun Hua, Guo Chen
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113511- (2023)
Summary: KRAS mutations are frequently detected in non-small cell lung cancers (NSCLCs). Although covalent KRASG12C inhibitors have been developed to treat KRASG12C-mutant cancers, effective treatments are still lacking for other KRAS-mutant NSCLCs.
Externí odkaz:
https://doaj.org/article/9e805ddd99bd46528a03270fc5c0833e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Stilbenes are characterized by a vinyl group connecting two benzene rings to form the basic parent nucleus. Hydrogen atoms on different positions of the benzene rings can be substituted with hydroQxyl groups. These unique structural features confer a
Externí odkaz:
https://doaj.org/article/44366fcce0694fb18fad26c1bc6997df
Autor:
Lina Liu, Wenjie Xin, Qiang Li, Baolian Huang, Te Yin, Siqi Hua, Chen Yang, Chen Chen, Chao Han, Zichun Hua
Publikováno v:
Advanced Science, Vol 10, Iss 29, Pp n/a-n/a (2023)
Abstract Oncolytic bacteria are the most promising tumor target vector. Questions also remain regarding finding a balance between the therapeutic efficacy and safety of oncolytic bacteria. The critical measure of how this balance is maintained is the
Externí odkaz:
https://doaj.org/article/32f66ad276c1444fb4849239032b1598
Autor:
Leyang Wu, Lin Li, Shufeng Li, Lina Liu, Wenjie Xin, Chenyang Li, Xingpeng Yin, Xuebo Xu, Feifei Bao, Zichun Hua
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 10, Pp 3952-3971 (2022)
Bacterial antitumor therapy has great application potential given its unique characteristics, including genetic manipulation, tumor targeting specificity and immune system modulation. However, the nonnegligible side effects and limited efficacy of cl
Externí odkaz:
https://doaj.org/article/3f3c393e21c2420eb8e2b3dfebfdca2a