Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ziaur S.M. Rahman"'
Autor:
Adam J. Fike, Sathi Babu Chodisetti, Nathaniel E. Wright, Kristen N. Bricker, Phillip P. Domeier, Mark Maienschein-Cline, Aaron M. Rosenfeld, Sara A. Luckenbill, Julia L. Weber, Nicholas M. Choi, Eline T. Luning Prak, Malay Mandal, Marcus R. Clark, Ziaur S.M. Rahman
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112512- (2023)
Summary: Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for signal transducer and activator of transcription 3 (STAT3) in GC DZ and LZ organizati
Externí odkaz:
https://doaj.org/article/90bb71ba5bd34d068395ef2779c48824
Selenium supplementation suppresses immunological and serological features of lupus in B6.Sle1b mice
Publikováno v:
Autoimmunity, Vol 52, Iss 2, Pp 57-68 (2019)
Systemic lupus erythematosus (SLE) is a debilitating multi-factorial immunological disorder characterized by increased inflammation and development of anti-nuclear autoantibodies. Selenium (Se) is an essential trace element with beneficial anti-cance
Externí odkaz:
https://doaj.org/article/754cca12b3b0417289742e6b20eacc2c
Autor:
Phillip P. Domeier, Sathi Babu Chodisetti, Stephanie L. Schell, Yuka Imamura Kawasawa, Melinda J. Fasnacht, Chetna Soni, Ziaur S.M. Rahman
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 406-418 (2018)
Summary: Type 1 interferon (T1IFN) signaling promotes inflammation and lupus pathology, but its role in autoreactive B cell development in the antibody-forming cell (AFC) and germinal center (GC) pathways is unclear. Using a lupus model that allows f
Externí odkaz:
https://doaj.org/article/7b9796ea1cb348bc9d2f93a94e94cf06
Publikováno v:
Sci Immunol
Long-lived and high-affinity antibodies are derived from germinal center (GC) activity, but the cytokines that regulate GC function are still being identified. Here, we show that thymic stromal lymphopoietin (TSLP) signaling regulates the GC and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9532078d25ed34a4785da034121b56ca
https://doi.org/10.1126/sciimmunol.add9413
https://doi.org/10.1126/sciimmunol.add9413
Autor:
Scott M. Emrich, Ryan E. Yoast, Xuexin Zhang, Adam J. Fike, Yin-Hu Wang, Kristen N. Bricker, Anthony Tao, Ping Xin, Vonn Walter, Martin T. Johnson, Trayambak Pathak, Adam C. Straub, Stefan Feske, Ziaur S.M. Rahman, Mohamed Trebak
The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e396a01d7ac2ecf4a599e7218f0ccbf
https://doi.org/10.1101/2022.05.06.490918
https://doi.org/10.1101/2022.05.06.490918
Autor:
Scott M. Emrich, Ryan E. Yoast, Adam J. Fike, Kristen N. Bricker, Ping Xin, Xuexin Zhang, Ziaur S.M. Rahman, Mohamed Trebak
Publikováno v:
Cell Calcium. 108:102667
Antigen receptor stimulation triggers cytosolic Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97533e72d921e3a5ffa0aa5b32b01523
https://doi.org/10.1016/j.ceca.2022.102667
https://doi.org/10.1016/j.ceca.2022.102667
Publikováno v:
The Journal of Immunology. 202:121.12-121.12
Germinal centers (GCs) generate high affinity B cell responses that are protective against infection but can produce autoreactive responses when dysregulated. MicroRNAs (miRNAs) have been implicated in the regulation of GC fate, though the role of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559ace3676592067c46e94e26a4d0cab
https://doi.org/10.4049/jimmunol.202.supp.121.12
https://doi.org/10.4049/jimmunol.202.supp.121.12
Publikováno v:
The Journal of Immunology. 200:40.5-40.5
Toll like receptor 7 (TLR7) is required for the development of spontaneous germinal center (Spt-GC) mediated autoimmunity. Accordingly, autoimmune-prone B6.Sle1b mice carrying an extra copy of TLR7 in the Yaa locus (named B6.Sle1bYaa mice) exhibit si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a3830a78870b2a07cae2ea96886597a
https://doi.org/10.4049/jimmunol.200.supp.40.5
https://doi.org/10.4049/jimmunol.200.supp.40.5
Autor:
Rita Y.Y. Yong, Soe Kyaw Tin, Ziaur S.M. Rahman, Chiu Han Ho, Dow Rhoon Koh, Pia Nina L. Buenaventura, Eric P.H. Yap
Publikováno v:
The Journal of Immunology. 168:3042-3049
Systemic lupus erythematosus (SLE) is inherited as a complex polygenic trait. (New Zealand Black (NZB) × New Zealand White (NZW)) F1 hybrid mice develop symptoms that remarkably resemble human SLE, but (NZB × PL/J)F1 hybrids do not develop lupus. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c045bc5d8487b7e44b82c283f6e4c7ea
https://doi.org/10.4049/jimmunol.168.6.3042
https://doi.org/10.4049/jimmunol.168.6.3042
Publikováno v:
The Journal of Immunology. 198:80.9-80.9
MerTK is a scavenger receptor involved in anti-inflammatory efferocytosis. We previously reported that MerTK deficiency on a mixed B6 and 129 background (B6-129.MerKO) led to dysregulated germinal center (GC) responses and accumulation of apoptotic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2b76f0f81c6b7af58009964fee8875
https://doi.org/10.4049/jimmunol.198.supp.80.9
https://doi.org/10.4049/jimmunol.198.supp.80.9