Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib

Autor: Pilar de la Puente, Barbara Muz, Richard Alvarez, Ziad S. Kawar, Abdel Kareem Azab, Feda Azab, Scott Rollins

Publikováno v: BioMed Research International, Vol 2015 (2015)
BioMed Research International

Multiple myeloma (MM) is a plasma cell malignancy localized in the bone marrow. Despite the introduction of novel therapies majority of MM patients relapse. We have previously shown that inhibition of P-selectin and P-selectin glycoprotein ligand-1 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c05dee9055716171ae1d6cda6cc501b
https://doi.org/10.1155/2015/417586

Novel Poly-GalNAcβ1–4GlcNAc (LacdiNAc) and Fucosylated Poly-LacdiNAc N-Glycans from Mammalian Cells Expressing β1,4-N-Acetylgalactosaminyltransferase and α1,3-Fucosyltransferase

Autor: Richard D. Cummings, Howard R. Morris, Ziad S. Kawar, Stuart M. Haslam, Anne Dell

Publikováno v: Journal of Biological Chemistry. 280:12810-12819

Glycans containing the GalNAcbeta1-4GlcNAc (LacdiNAc or LDN) motif are expressed by many invertebrates, but this motif also occurs in vertebrates and is found on several mammalian glycoprotein hormones. This motif contrasts with the more commonly occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5f3d75acc9dd0c2658f2762b262f93
https://doi.org/10.1074/jbc.m414273200

PSGL-1 from the murine leukocytic cell line WEHI-3 is enriched for core 2-based O-glycans with sialyl Lewis x antigen

Autor: Ziad S. Kawar, Richard D. Cummings, John B. Lowe, Thomas K Johnson, Suvi Natunen

Leukocyte trafficking involves specific recognition between P-selectin and L-selectin and PSGL-1 containing core 2-based O-glycans expressing sialyl Lewis x (SLe(x)) antigen. However, the structural identity of the glycan component(s) displayed by mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed2190e0154bbdcd4981511cdb1ef37
https://europepmc.org/articles/PMC2727551/

Specificity of DC-SIGN for mannose- and fucose-containing glycans

Autor: Ziad S. Kawar, Richard Alvarez, Juan Jesús Garcı´a-Vallejo, Ellis van Liempt, Padmaja Mehta, Irma van Die, Rudolf Geyer, Christine M C Bank, Richard D. Cummings, Yvette van Kooyk

Publikováno v: van Liempt, E, Bank, C M C, Mehta, P, Garciá-Vallejo, J J, Kawar, Z S, Geyer, R, Alvarez, R A, Cummings, R D, Kooyk, Y V & van Die, I 2006, ' Specificity of DC-SIGN for mannose-and fucose-containing glycans ', FEBS Letters, vol. 580, no. 26, pp. 6123-31 . https://doi.org/10.1016/j.febslet.2006.10.009
FEBS Letters, 580(26), 6123-31. Wiley-Blackwell

The dendritic cell specific C-type lectin dendritic cell specific ICAM-3 grabbing non-integrin (DC-SIGN) binds to "self" glycan ligands found on human cells and to "foreign" glycans of bacterial or parasitic pathogens. Here, we investigated the bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5668c528b3efb3a52e2cff489d9188b9
https://research.vumc.nl/en/publications/8ad6e7cf-ba86-4b4c-a5fd-50009f74f506

Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitors

Autor: Richard Alvarez, Barbara Muz, Scott A. Rollins, Ziad S. Kawar, Abdel Kareem Azab, Feda Azab, Pilar de la Puente

Publikováno v: Blood. 124:4758-4758

Introduction: Multiple myeloma (MM) is a plasma cell malignancy localized in the bone marrow (BM). Despite the introduction of novel therapies more than 70% of MM patients relapse. We have previously shown that inhibition of P-selectin and P-selectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e47e68177ccea037db650d42ee35b417
https://doi.org/10.1182/blood.v124.21.4758.4758