Zobrazeno 1 - 10
of 1 080
pro vyhledávání: '"ZiXin Deng"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 4, Pp 609-617 (2024)
Spinosad, a potent broad-spectrum bioinsecticide produced by Saccharopolyspora spinosa, has significant market potential. Despite its effectiveness, the regulatory mechanisms of spinosad biosynthesis remain unclear. Our investigation identified the c
Externí odkaz:
https://doaj.org/article/fad55bbbb66b42e6b1aabee1a1c2c9f2
Autor:
Ran Liu, Zixuan Luo, Chong Dai, Yuchen Wei, Shuqing Yan, Xinwen Kuang, Kuan Qi, Aisi Fu, Yinxin Li, Shuai Fu, Zhengning Ma, Wen Dai, Xiao Xiao, Qing Wu, Haokui Zhou, Yan Rao, Jingping Yuan, Ting Shi, Zixin Deng, Chuang Chen, Tiangang Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Granulomatous lobular mastitis (GLM) is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence, the incidence rate has gradually increased, and has become a ser
Externí odkaz:
https://doaj.org/article/adcc4e82a8d94ba1948b890e62bb514a
Autor:
Yongjian Qiao, Junbo Wang, Dashan Zhang, Xiaoqing Zheng, Baixin Lin, Yongkang Huang, Yulin Liao, Zixin Deng, Lingxin Kong, Delin You
Publikováno v:
Synthetic and Systems Biotechnology, Vol 10, Iss 1, Pp 76-85 (2025)
Anisomycin (compound 1), a multifunctional pyrrolidine antibiotic, primarily inhibits protein biosynthesis by binding to the ribosome. Upon binding to the ribosome, the para-phenol moiety of anisomycin inserts completely into the hydrophobic crevice
Externí odkaz:
https://doaj.org/article/54414fec2e0e4c5faa482a1153bf00ef
Publikováno v:
Journal of Applied Science and Engineering, Vol 28, Iss 6, Pp 1311-1320 (2024)
The determination of rock’s Capillary water absorption (CWA) requires extensive and complex empirical investigations, while forecasting algorithms could reduce the cost and time required. To achieve this goal, various rock records were collected f
Externí odkaz:
https://doaj.org/article/7c26d3297ec04db99cf5f0472b7526ec
Autor:
Xinyun Jian, Cheng Wang, Shijuan Wu, Guo Sun, Chuan Huang, Chengbing Qiu, Yuanzheng Liu, Peter F. Leadlay, Dong Liu, Zixin Deng, Fuling Zhou, Yuhui Sun
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4149-4163 (2024)
Aminoglycosides (AGs) are a class of antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance. To address these issues, semi-synthetic a
Externí odkaz:
https://doaj.org/article/3c9d502866b64bac866eccc70201f248
Autor:
Jian Wang, Ke Wang, Zhe Deng, Zhiyu Zhong, Guo Sun, Qing Mei, Fuling Zhou, Zixin Deng, Yuhui Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Base editing (BE) faces protospacer adjacent motif (PAM) constraints and off-target effects in both eukaryotes and prokaryotes. For Streptomyces, renowned as one of the most prolific bacterial producers of antibiotics, the challenges are mor
Externí odkaz:
https://doaj.org/article/34f1a8776d9b4f278eeafa2901ac11cb
Autor:
Pan Yan, Gang Wang, Minjian Huang, Zhen Liu, Chong Dai, Ben Hu, Meijia Gu, Zixin Deng, Ran Liu, Xinghuan Wang, Tiangang Liu
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Polyethers play a crucial role in the development of anticancer drugs. To enhance the anticancer efficacy and reduce the toxicity of these compounds, thereby advancing their application in cancer treatment, herein, guided by the structure‐
Externí odkaz:
https://doaj.org/article/9d80ef7bd3e9468789bac8bd748b420f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
BackgroundMetronidazole (MTZ) is among the first-line drugs against the human gastric pathogen Helicobacter pylori (H. pylori). MTZ is used as a prodrug that is activated by an oxygen-insensitive enzyme NADPH nitroreductase (RdxA). Loss-of-function m
Externí odkaz:
https://doaj.org/article/e73a327e9c7444d2ac8e19d614688366
Autor:
Zhihong Xiao, Jinyin Zha, Xu Yang, Tingting Huang, Shuxin Huang, Qi Liu, Xiaozheng Wang, Jie Zhong, Jianting Zheng, Rubing Liang, Zixin Deng, Jian Zhang, Shuangjun Lin, Shaobo Dai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Modulation of protein function through allosteric regulation is central in biology, but biomacromolecular systems involving multiple subunits and ligands may exhibit complex regulatory mechanisms at different levels, which remain poorly unde
Externí odkaz:
https://doaj.org/article/f12afcd0d3fe4a8aa04a442de2c9aa0d
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Selenium is an essential multifunctional trace element in diverse organisms. The only Se-glycosyltransferase identified that catalyzes the incorporation of selenium in selenoneine biosynthesis is SenB from Variovorax paradoxus. Although the
Externí odkaz:
https://doaj.org/article/7e579f2b17b343e7862741f6e9fd33a2