Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Zi-xuan Wang"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract The prominence and versatility of propargylic fluorides in medicinal chemistry, coupled with the potency of F/H and F/OH bioisosterism, has created a powerful impetus to develop efficient methods to facilitate their construction. Motivated b
Externí odkaz:
https://doaj.org/article/09a1577a35c64832aa953e4b38bfad7e
Autor:
Xiao-Fei Zhang, Zi-Xuan Wang, Bo-Wen Zhang, Kun-Peng Huang, Tian-Xing Ren, Ting Wang, Xing Cheng, Ping Hu, Wei-Hua Xu, Jin Li, Jin-Xiang Zhang, Hui Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102164- (2024)
Transforming growth factor β 1 (TGF-β1), as the most abundant signaling molecule in bone matrix, is essential for bone homeostasis. However, the signaling transduction of TGF-β1 in the bone-forming microenvironment remains unknown. Here, we showed
Externí odkaz:
https://doaj.org/article/e9eedb93e0224816b3e445ae3726dc9f
Publikováno v:
Water Biology and Security, Vol 3, Iss 2, Pp 100248- (2024)
Maternal immunity plays a vital role in protecting offspring from pathogen invasion, and it is present in nearly all vertebrates. As the most ancient vertebrates, teleost fish continuously secrete a substantial amount of mucus due to their unique liv
Externí odkaz:
https://doaj.org/article/34597ae66d4b4974a1cbb2a66513cf53
Autor:
Tian‐Hua Wei, Meng‐Yi Lu, Si‐Hui Yao, Yu‐Qi Hong, Jin Yang, Meng‐Yuan Zhang, Yu‐Qi Yin, Yu‐Jie Han, Qing‐Qing Li, Zi‐Xuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Yun Zhou, Wei‐Chen Dai, Yan‐Cheng Yu, Shan‐Liang Sun, Ye Yang, Nian‐Guang Li, Zhi‐Hao Shi
Publikováno v:
MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity. This review focuses on the structur
Externí odkaz:
https://doaj.org/article/29262a2be1a6426fa1afb92378ccb3fb
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-7 (2023)
Abstract Background Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors
Externí odkaz:
https://doaj.org/article/1b2139c19a994182b2324b110d6530de
Autor:
Jin ZHANG, Jie WANG, Qiao WANG, Huan-xian CUI, Ji-qiang DING, Zi-xuan WANG, Mamadou THIAM, Qing-he LI, Gui-ping ZHAO
Publikováno v:
Journal of Integrative Agriculture, Vol 22, Iss 9, Pp 2810-2823 (2023)
Enhancing host immunity is an effective way to reduce morbidity in chickens. Heterophil to lymphocyte ratio (H/L) is associated with host disease resistance in birds. Chickens with different H/L levels show different disease resistances. However, the
Externí odkaz:
https://doaj.org/article/cbd5232227f1418dbd54e937527c3a94
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 100973- (2024)
Externí odkaz:
https://doaj.org/article/516765282185421080602d0a195e35e4
Autor:
Shan-Liang Sun, Jia-Zhen Wu, Jing-Jing Wang, Hai Zhou, Chen-Qian Zhang, Zhen-Jiang Tong, Yi-Bo Wang, Jiu-Kai Sha, Qing-Xin Wang, Jia-Chuan Liu, Xin-Rui Zheng, Qing-Qing Li, Meng-Yuan Zhang, Jin Yang, Tian-Hua Wei, Zi-Xuan Wang, Yan-Cheng Yu, Ning Ding, Xue-Jiao Leng, Xin Xue, He-Min Li, Wei-Chen Dai, Xiao-Ying Yin, Ye Yang, Jin-Ao Duan, Nian-Guang Li, Zhi-Hao Shi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115905- (2023)
The therapeutic benefits of available FLT3 inhibitors for AML are limited by drug resistance, which is related to mutations, as well toxicity caused by off-target effects. In this study, we introduce a new small molecule FLT3 inhibitor called danatin
Externí odkaz:
https://doaj.org/article/b4a16bb41b1041b8acc5195b558148af
Publikováno v:
Plant Diversity, Vol 45, Iss 2, Pp 229-233 (2023)
Knowledge of which biological and functional traits have, or lack, phylogenetic signal in a particular group of organisms is important to understanding the formation and functioning of biological communities. Allometric biomass models reflecting tree
Externí odkaz:
https://doaj.org/article/e0ecc4f98f0247409dc2b642e105373e
Publikováno v:
Ecological Indicators, Vol 154, Iss , Pp 110497- (2023)
Farmers and ranchers living in snow mountainous regions heavily rely on melting snow for agricultural irrigation. However, major natural disturbances, such as wildfires, have markedly reduced melt durations, disrupting the local hydrological cycle. I
Externí odkaz:
https://doaj.org/article/816ea85ef03247789aa12bdd56561336