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Discovery of a Series of Nonpeptide Small Molecules That Inhibit the Binding of Insulin-like Growth Factor (IGF) to IGF-Binding Proteins

Autor: Zi-Xian Lu, Chen Chen, Qiu Xie, Yun-Fei Zhu, Nicholas Ling, Xin-Jun Liu

Publikováno v: Journal of Medicinal Chemistry. 44:4001-4010

Insulin-like growth factors (IGF-I and II) play an important role in metabolic and mitogenic activities through stimulation of the IGF-I receptor on the cell surface. Although the concentration of IGF in blood and cerebrospinal fluid is quite high (>

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6bb59a01236dd94605d1c938d3a45e
https://doi.org/10.1021/jm010304b

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Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke

Autor: Errol B. De Souza, Changlu Liu, Zi Xian Lu, Xin-Jun Liu, Sarah A. Loddick, Derek Chalmers, Wylie Vale, Alan C. Foster, Nicholas Ling, Dominic P. Behan

Publikováno v: Proceedings of the National Academy of Sciences. 95:1894-1898

Insulin-like growth factors I and II (IGF-I and IGF-II) play an important role in normal growth and brain development and protect brain cells from several forms of injury. The effects of IGFs are mediated by type-I and type-II receptors and modulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21743638485a8e5bc99280d8bb583c10
https://doi.org/10.1073/pnas.95.4.1894

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Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions

Autor: Zi Xian Lu, Steven E. Shoelson, Michael A. Weiss, Claire S. Lynch, Lina Parlautan

Publikováno v: Biochemistry. 31:1757-1767

Mutagenesis of the dimer- and hexamer-forming surfaces of insulin yields analogues with reduced tendencies to aggregate and dramatically altered pharmacokinetic properties. We recently showed that one such analogue, HisB10----Asp, ProB28----Lys, LysB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65498236dbc4ecd51ccfea855dc154a1
https://doi.org/10.1021/bi00121a025

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BACK MATTER

Autor: Zai-ping Li, Zi-xian Lu, You-shang Zhang

Publikováno v: Retrospect and Prospect of Protein Research. :257-264

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bfe2ea72040093321e9821693f78219
https://doi.org/10.1142/9789814360425_bmatter

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FRONT MATTER

Autor: Zai-ping Li, Zi-xian Lu, You-shang Zhang

Publikováno v: Retrospect and Prospect of Protein Research. :i-xv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f964367895a7658afc1dec34e2dffeb
https://doi.org/10.1142/9789814360425_fmatter

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[Advances in the studies of plant basic leucine zipper (bZIP) proteins (B)--DNA-binding property, gene expression, function and application]

Autor: Zi-Xian, Lu, Tuan-Jie, Chang, Xiang, Liu, Zhen, Zhu

Publikováno v: Yi chuan = Hereditas. 24(2)

Plant basic leucine zipper (bZIP) proteins play an important role in the expression and regulation of higher plant genes. The DNA-binding properties of plant bZIP protein are introduced first in this article. Then their expression and function are di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3fb07bb04d43a55eb0169c6b2563b46
https://pubmed.ncbi.nlm.nih.gov/16118139

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