Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Zi-wei Ye"'
Autor:
Chris Chun-Yiu Chan, Qian Guo, Jasper Fuk-Woo Chan, Kaiming Tang, Jian-Piao Cai, Kenn Ka-Heng Chik, Yixin Huang, Mei Dai, Bo Qin, Chon Phin Ong, Allen Wing-Ho Chu, Wan-Mui Chan, Jonathan Daniel Ip, Lei Wen, Jessica Oi-Ling Tsang, Tong-Yun Wang, Yubin Xie, Zhenzhi Qin, Jianli Cao, Zi-Wei Ye, Hin Chu, Kelvin Kai-Wang To, Xing-Yi Ge, Tao Ni, Dong-Yan Jin, Sheng Cui, Kwok-Yung Yuen, Shuofeng Yuan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4028-4044 (2024)
There are only eight approved small molecule antiviral drugs for treating COVID-19. Among them, four are nucleotide analogues (remdesivir, JT001, molnupiravir, and azvudine), while the other four are protease inhibitors (nirmatrelvir, ensitrelvir, le
Externí odkaz:
https://doaj.org/article/e580066405f243c6820a3a4400b16bcf
Autor:
Yibo Tang, Kaiming Tang, Yunqi Hu, Zi-Wei Ye, Wanyu Luo, Cuiting Luo, Hehe Cao, Ran Wang, Xinyu Yue, Dejian Liu, Cuicui Liu, Xingyi Ge, Tianlong Liu, Yaoqing Chen, Shuofeng Yuan, Lei Deng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe frequent occurrence of mutations in the SARS-CoV-2 Spike (S) protein, with up to dozens of mutations, poses a severe threat to the current efficacy of authorized COVID-19 vaccines. Membrane (M) protein, which is the most abundant vira
Externí odkaz:
https://doaj.org/article/eed85f45390a42399012fa3608b922f9
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105324- (2024)
Externí odkaz:
https://doaj.org/article/9244cc8312974a49903aec478f7ce9b7
Autor:
Ronghui Liang, Zi-Wei Ye, Zhenzhi Qin, Yubin Xie, Xiaomeng Yang, Haoran Sun, Qiaohui Du, Peng Luo, Kaiming Tang, Bodan Hu, Jianli Cao, Xavier Hoi-Leong Wong, Guang-Sheng Ling, Hin Chu, Jiangang Shen, Feifei Yin, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Shuofeng Yuan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Host survival depends on the elimination of virus and mitigation of tissue damage. Herein, we report the modulation of D-mannose flux rewires the virus-triggered immunometabolic response cascade and reduces tissue damage. Safe and inexpensiv
Externí odkaz:
https://doaj.org/article/172ab913f5fd4fd68985cd7d66bf32cb
Autor:
Wai-Yin Lui, Chon Phin Ong, Pak-Hin Hinson Cheung, Zi-Wei Ye, Chi-Ping Chan, Kelvin Kai-Wang To, Kit-San Yuen, Dong-Yan Jin
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSARS-CoV-2, the causative agent of COVID-19, has been intensely studied in search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has been suggested to be a pan-coronavirus inhibitor, yet its underlying mechanism
Externí odkaz:
https://doaj.org/article/e71fe5a1eb514d30af75e326098c46a3
Autor:
Chon Phin Ong, Kaiming Tang, Pak-Hin Hinson Cheung, Hongzhuo Zhang, Tze-Tung Tang, Yaqian Xue, Junjue Wang, Kelvin Kai-Wang To, Shuofeng Yuan, Zi-Wei Ye, Dong-Yan Jin
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-5 (2023)
Abstract We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effecti
Externí odkaz:
https://doaj.org/article/e460d8cd22ca4a1b98a50cc044fc51a8
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104968- (2024)
Externí odkaz:
https://doaj.org/article/d9e30c6f3c79490ca259fe058682972d
Autor:
Zi-Wei Ye, Zhong-Yu Yuan, Jun Wang, Hua Li, Cheng-Fu Li, Guang-Hui Xu, Li-Tao Yi, Wei-Feng Huang
Publikováno v:
Journal of Functional Foods, Vol 112, Iss , Pp 105951- (2024)
Inflammatory bowel disease (IBD) often coexists with depression, posing considerable challenges for treatment. This study aimed to investigate the therapeutic potential of fucoidan, a compound derived from Laminaria japonica, in a dextran sulfate sod
Externí odkaz:
https://doaj.org/article/53cbcc275bf94e34b4e9c82b09b9dece
Autor:
Yun Cheng, Xiao-Zhuo Kang, Pearl Chan, Pak-Hin Hinson Cheung, Tao Cheng, Zi-wei Ye, Chi-Ping Chan, Cheng-Han Yu, Dong-Yan Jin
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Background Cholesterol plays a vital role in multiple physiological processes. Cellular uptake of cholesterol is mediated primarily through endocytosis of low-density lipoprotein (LDL) receptor. New modifiers of this process remain to be cha
Externí odkaz:
https://doaj.org/article/151620cd7ddc47e79eb1d9848509abc0
Autor:
Xuanming Guo, Jianli Cao, Jian-Piao Cai, Jiayan Wu, Jiangang Huang, Pallavi Asthana, Sheung Kin Ken Wong, Zi-Wei Ye, Susma Gurung, Yijing Zhang, Sheng Wang, Zening Wang, Xin Ge, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Nathalie Wong, Jiandong Huang, Zhongjun Zhou, Zhao-Xiang Bian, Shuofeng Yuan, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The role of soluble angiotensin converting enzyme 2 (sACE2) in SARS-CoV-2 infection is not well understood. Here, authors show that membrane type 1 matrix metalloproteinase (MT1-MMP) releases sACE2 to promote SARS-CoV-2 cell entry in vitro and in viv
Externí odkaz:
https://doaj.org/article/b805e181bd2d4dafb2de5ce5eb516da8