Výsledky vyhledávání - "Zi-Sheng Kang"

Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against Enterobacteriaceae

Autor: Wei Zhong, Isabelle H. S. Kuan, Zi-Sheng Kang, Xi-Wei Ji, Yun Li, Xiao Zhu, Yuan Lv, Xi-Ping Yang, Feng Xue

Publikováno v: Antimicrobial Agents and Chemotherapy. 64

Benapenem is a novel carbapenem. The objective of this study was to determine the pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal administration regimens of benapenem for the treatment of bacterial infections via PK/P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c2a16f47264fd4e01434077a754874f
https://doi.org/10.1128/aac.01751-19

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Effects ofUGT1A1, CYP3A5andABCB1Genetic Variants on Pharmacokinetics of Antihistamine Drug Mizolastine in Chinese Healthy Volunteers

Autor: Sheng-Ju Yin, Min-Ji Wei, Pu Li, Ya-Qing Lou, Xuan Wei, Zi-Sheng Kang, Suo-Di Zhai, Xin Wang, Yuan Lu, Zhi-Yuan Zhang, Guo-Liang Zhang

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 123:464-473

Mizolastine is a selective histamine H1 receptor antagonist for chronic urticaria or allergic rhinitis. We investigated whether the variant genotypes of metabolic enzymes UGT1A1, CYP3A5 and transporter ABCB1 influence pharmacokinetic phenotype of sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d17e25ce57a8059603cea8a31a96951
https://doi.org/10.1111/bcpt.13028

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Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against

Autor: Xi-Wei, Ji, Feng, Xue, Zi-Sheng, Kang, Wei, Zhong, Isabelle Hui-San, Kuan, Xi-Ping, Yang, Xiao, Zhu, Yun, Li, Yuan, Lv

Publikováno v: Antimicrobial Agents and Chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36f673ee2020722eb89ab55e1b5a9f1a
https://pubmed.ncbi.nlm.nih.gov/31844001

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A First-in-Human Safety, Tolerability, and Pharmacokinetics Study of Benapenem in Healthy Chinese Volunteers

Autor: Min-Ji Wei, Xi-Wei Ji, Meng-Ying Liu, Yan Liu, Yan Ma, Yan Zhu, Yuan Lv, Ya-Hong Xia, Zi-Sheng Kang, Cai-Yun Zhao, Ji-Hong Tian

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Objective: The objective of this trial is to investigate the safety, tolerability and pharmacokinetics (PK) of benapenem administrated by single or multiple intravenous infusions in healthy Chinese volunteers. Methods: The trial was divided into 3 pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c7e41f4ed7812681affb97d91f32da
https://doi.org/10.1128/aac.02188-18

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A Randomized Study of the Single-Dose Safety, Pharmacokinetics, and Food Effect of Chinfloxacin and Its Effect on Thorough QT/QTc Interval in Healthy Chinese Volunteers

Autor: Yan Liu, Xiangyan Li, Jin Wang, Ji-Hong Tian, Min-Ji Wei, Yuan Lv, Xuzhu Ma, Wei Mao, Fang Hou, Zi-Sheng Kang, Cai-Yun Zhao, Ya-Hong Xia

Chinfloxacin hydrochloride is a novel tricyclic fluorinated quinolone in development for treatment of conventional and biothreat infections. This first-in-human randomized study in Chinese healthy subjects was divided into 5 parts. Part A was a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289434603e40f75e248dfff972526b82
https://europepmc.org/articles/PMC6256790/

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Effects of Nemonoxacin on Thorough ECG QT/QTc Interval: A Randomized, Placebo- and Positive-controlled Crossover Study in Healthy Chinese Adults

Autor: Fang Hou, Zi-Sheng Kang, Min-Ji Wei, Ji-Hong Tian, Xiangyan Li, Ya-Hong Xia, Yuan Lv, Cai-Yun Zhao, Xuzhu Ma, Yan Liu, Lanqing Cui

Publikováno v: Clinical therapeutics. 40(6)

Purpose Nemonoxacin, a nonfluorinated quinolone, has been approved in Taiwan and mainland China for the treatment of bacterial infection. Whether nemonoxacin is associated with the adverse events of other quinolones, such as the risk for QT-interval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4e53e54b83da7adec95027e70e8a7d
https://pubmed.ncbi.nlm.nih.gov/29803534

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Pharmacokinetics of antofloxacin hydrochloride, a new fluoroquinolone antibiotic, after single oral dose administration in Chinese healthy male volunteers

Autor: Man Zhang, Tian-yun Li, Yan Liu, Ming Zhang, Zi-sheng Kang, Yuan Lu, Yong-hong Xiao

Publikováno v: Biopharmaceutics & Drug Disposition. 29:167-172

Antofloxacin hydrochloride is a newly developed fluoroquinolone antibacterial in China, which has comparable in vitro and animal pharmacological and toxicological properties to levofloxacin and is worthy of further clinical trial. Human tolerance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd12f43d05d7e5fe70630a8e5345d54
https://doi.org/10.1002/bdd.600

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Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers

Autor: Yuan, Lü, Zi-Sheng, Kang, Yan, Zhu, Ming, Zhang, Yan, Liu, Man, Zhang, Tian-Yun, Li, Yong-Hong, Xiao

Publikováno v: Chinese medical journal. 124(2)

A new fluroquinolone antibacterial agent, antofloxacin hydrochloride, developed in China, is an 8-NH(2) derivant of levofloxacin. The purpose of the study was to evaluate the pharmacokinetic characteristics of single and multiple oral doses of antofl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31daf923ff10889bd955135b13a38851
https://pubmed.ncbi.nlm.nih.gov/21362374

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