Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zi-Li Ren"'
Publikováno v:
Molecules, Vol 20, Iss 1, Pp 807-821 (2015)
A series of novel pyrazole amide derivatives 3a–3p which take TMV PC protein as the target has been designed and synthesized by the reactions of 5-chloro-1-aryl-3-methyl-1H-pyrazole-4-carboxylic acids with 5-amino-1-aryl-1H-pyrazole-4-carbonitriles
Externí odkaz:
https://doaj.org/article/d52f84adb2884c9d92972ccaab2d9a96
Autor:
Ming-Jie Chu, Wei Wang, Zi-Li Ren, Hao Liu, Xiang Cheng, Kai Mo, Li Wang, Feng Tang, Xian-Hai Lv
Publikováno v:
Molecules, Vol 24, Iss 7, p 1311 (2019)
To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the mos
Externí odkaz:
https://doaj.org/article/bebcccf0b19649af95cb2501f06f1e9b
Autor:
Hao Liu, Xian-Hai Lv, Ai-Li Wang, Haiqun Cao, Zi-Li Ren, Di Jiao, Hao-Tian Hu, Jie-Xiu Gong, Wei Wang
Publikováno v:
Drug Development Research. 79:307-312
Hit, Lead & Candidate Discovery To discover succinate dehydrogenase inhibitors with a novel structure, we introduced cinnamic acid structure to optimize the lead structure 1 and synthesized four series of cinnamon-pyrazole carboxamide derivatives. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9c1d8057e9affc6e0ce937d7d3db68
https://doi.org/10.1002/ddr.21469
https://doi.org/10.1002/ddr.21469
Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents
Autor:
Dao-Hong Liu, Zi-Li Ren, Ming-Jie Chu, Xian-Hai Lv, Qing-Shan Li, Ban-Feng Ruan, Kai Mo, Haiqun Cao, Dong-Dong Li, Cheng-Ying Ai
Publikováno v:
Chinese Chemical Letters. 28:377-382
Many pyrazole derivatives were reported to exhibit highly activity towards tobacco mosaic virus (TMV). In this work, an optimized pyrazole Schiff base scaffold was designed and introduced to derive novel potential TMV inhibitors. Thirty-six compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307c8ed3f45228faa25ac7103dca61fd
https://doi.org/10.1016/j.cclet.2016.10.029
https://doi.org/10.1016/j.cclet.2016.10.029
Autor:
Wei Wang, Xian-Hai Lv, Li Wang, Xiang Cheng, Ming-Jie Chu, Zi-Li Ren, Hao Liu, Kai Mo, Feng Tang
Publikováno v:
Molecules
Molecules, Vol 24, Iss 7, p 1311 (2019)
Volume 24
Issue 7
Molecules, Vol 24, Iss 7, p 1311 (2019)
Volume 24
Issue 7
To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926ad7357f64467627992a635f4e54b6
http://europepmc.org/articles/PMC6480153
http://europepmc.org/articles/PMC6480153
Autor:
Ming-Jie Chu, Li-Song Zhang, Xiao-Kang Yao, Xian-Hai Lv, Ben-Guo Zhou, Kai Mo, Qing-Shan Li, Haiqun Cao, Dao-Hong Liu, Zi-Li Ren
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4652-4659
Mitogen activated protein kinase (MAPK) signal transduction pathway has been proved to play an important role in tumorigenesis and cancer development. MEK inhibitor has been demonstrated significant clinical benefit for blocking MAPK pathway activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc61be7601da7fcd4696c1c575da3a90
https://doi.org/10.1016/j.bmc.2016.08.002
https://doi.org/10.1016/j.bmc.2016.08.002
Autor:
Zi-Li Ren, Hai-Dong Li, Yong Xia, Haiqun Cao, Jing Zhang, Xian-Hai Lv, Ming-Jie Chu, Xiao-Kang Yao, Li-Song Zhang
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1755-1762
Acetylcholinesterase (AChE) is a key enzyme which present in the central nervous system of living organisms. Organophosphorus pesticides (OPs) that serve as insecticides are AChE inhibitors which have been used widely in agriculture. A series of nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eee55ad0c7958320430b22e8a29a195
https://doi.org/10.1248/cpb.c16-00622
https://doi.org/10.1248/cpb.c16-00622
Publikováno v:
Molecular diversity. 23(2)
A series of novel Mannich base derivatives of flavone containing benzylamine moiety was synthesized using the Mannich reaction. The results of antifungal activity are not ideal, but its antifungal effect has a certain increase compared to flavonoids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4a53f91faaeed5b7b1b9b7d59a8315
https://pubmed.ncbi.nlm.nih.gov/30168050
https://pubmed.ncbi.nlm.nih.gov/30168050
Autor:
Wei Wang, Ming-Jie Chu, Xian-Hai Lv, Zi-Li Ren, Jie-Xiu Gong, Quan-Wei Ma, Hao Liu, Jie-Chun Wang
Publikováno v:
European journal of medicinal chemistry. 157
The identification of novel Topoisomerase II (Topo II) inhibitors is one of the most attractive directions in the field of bactericide research and development. In our ongoing efforts to pursue the class of inhibitors, six series of 70 novel coumarin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b23035d797cb1088ff960dff6086c63
https://pubmed.ncbi.nlm.nih.gov/30075404
https://pubmed.ncbi.nlm.nih.gov/30075404
Autor:
Li-Song Zhang, Xian-Hai Lv, Xiao-Kang Yao, Qing-Shan Li, Hao Liu, Haiqun Cao, Zi-Li Ren, Hai-Dong Li, Li Wang
Publikováno v:
Chemicalpharmaceutical bulletin. 66(4)
Acetohydroxy acid synthase (AHAS; EC 2.2.1.6, also referred to as acetolactate synthase, ALS) has been considered as an attractive target for the design of herbicides. In this work, an optimized pyrazole sulfonamide base scaffold was designed and int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f684047b5b0bb8eac19c6ab07447f5
https://pubmed.ncbi.nlm.nih.gov/29607900
https://pubmed.ncbi.nlm.nih.gov/29607900