Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Zi-Jian Lan"'
Autor:
Penghao Sun, Hongliang Wang, Lingyun Liu, Kaimin Guo, Xian Li, Yin Cao, Chemyong Ko, Zi-Jian Lan, Zhenmin Lei
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
KRAS plays critical roles in regulating a range of normal cellular events as well as pathological processes in many tissues mediated through a variety of signaling pathways, including ERK1/2 and AKT signaling, in a cell-, context- and development-dep
Externí odkaz:
https://doaj.org/article/96df947e8b4541fbbc7b74bc721ca502
Publikováno v:
International Journal of Biological Sciences, Vol 4, Iss 1, Pp 29-36 (2008)
Hedgehog (Hh) signaling emerges as a potential pathway contributing to fat formation during postnatal development. In this report, we found that Patched 1 (Ptc1), a negative regulator of Hh signaling, was expressed in the epididymal fat pad of adult
Externí odkaz:
https://doaj.org/article/99ff60cafb784edba1b02a8b5ed25dd4
Autor:
Zhenmin Lei, Xian Li, Zi-Jian Lan, Thirupathi Reddy Yerramreddy, Hannah Gadberry, Lei Lei, Ronan Power, Olivia Seale, Hayley Kincaid, Katie Eastridge, Chloe Power, Rijin Xiao, Karl Dawson, Alexandros Yiannikouris
Publikováno v:
Cellular and Molecular Life Sciences
The pathophysiology of type 2 diabetes mellitus (T2D) is characterized by reduced or absent insulin receptor (INSR) responsiveness to its ligand, elevated hepatic glucose output and impaired glucose uptake in peripheral tissues, particularly skeletal
Autor:
Shengqiang Li, Zi-Jian Lan, Lingyun Liu, Penghao Sun, Kaimin Guo, Yin Cao, Jing Lin, Zhenmin Lei, Hongliang Wang, Xian Li
Publikováno v:
Journal of Cell Communication and Signaling
Numb (Nb) and Numb-like (Nbl) are functionally redundant adaptor proteins that critically regulate cell fate and morphogenesis in a variety of organs. We selectively deleted Nb and Nbl in testicular germ cells by breeding Nb/Nbl floxed mice with a tr
Autor:
Alexandros Yiannikouris, Thirupathi Reddy Yerramreddy, Zi-Jian Lan, Katie Eastridge, Lucinda Nation, Zhenmin Lei, Hayley Kincaid, Ryan Goettl, Ronan Power, Xian Li, Rijin Xiao
Publikováno v:
BMJ Open Diabetes Research & Care
IntroductionAdenosine, 5’-Se-methyl-5’-seleno-,2’,3’-diacetate (NPC43) is a recently identified small, non-peptidyl molecule which restores normal insulin signaling in a mouse model of type 2 diabetes (Lanet al). The present study investigate
Autor:
Lingyun Liu, Junmei Zhou, Zi-Jian Lan, Kaimin Guo, Xian Li, Yan He, Lu Cai, Hongliang Wang, Zuowen Liang, Zhenmin Lei
Publikováno v:
Journal of Cellular and Molecular Medicine
Gametogenetin (GGN) binding protein 2 (GGNBP2) is a zinc finger protein expressed abundantly in spermatocytes and spermatids. We previously discovered that Ggnbp2 resection caused metamorphotic defects during spermatid differentiation and resulted in
Publikováno v:
Journal of Reproduction & Infertility. Jul-Sep2014, Vol. 15 Issue 3, p122-133. 12p. 3 Color Photographs, 1 Black and White Photograph, 2 Charts, 3 Graphs.
Autor:
Xian Li, Michael Tseng, Lingyun Liu, Yan He, Linying Zhou, Zi-Jian Lan, Lu Cai, Kaimin Guo, Zhenmin Lei, Junmei Zhou, Hongliang Wang
Publikováno v:
The American Journal of Pathology. 187:2508-2519
Gametogenetin binding protein 2 (GGNBP2) is an evolutionarily conserved zinc finger protein. Although Ggnbp2 -null embryos in the B6 background died because of a defective placenta, 6.8% of Ggnbp2 -null mice in the B6/129 mixed background were viable
Autor:
G. Z. Wu, Huaxin Zhou, Austin J. Cooney, Xian Li, Junmei Zhou, Zi-Jian Lan, CheMyong Ko, M. S. Krause, Zhenmin Lei, Henry Bohler, S. D. Redding
Publikováno v:
Molecular and Cellular Endocrinology. 444:26-37
Theca cell-selective Pten mutation (tPtenMT) in mice resulted in increases in PDK1 and Akt phosphorylation, indicating an over-activation of PI3K signaling in the ovaries. These mice displayed elevated androgen levels, ovary enlargement, antral folli
Autor:
Tomas A. Prolla, Ronan Power, Zi-Jian Lan, Leya Spangler, Carrie Johnson, Rijin Xiao, Katie Routt
Publikováno v:
Functional Foods in Health and Disease, Vol 4, Iss 3, Pp 98-119 (2014)
Background: Age is a major risk factor in developing heart diseases and has been associated with profound transcriptional changes in mammalian tissues. Low tissue selenium has recently been linked to several age-related diseases, including cardiovasc