Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Zi Ru Dai"'
Autor:
Zi-Ru Dai, Jing Ning, Gui-Bo Sun, Ping Wang, Feng Zhang, Hong-Ying Ma, Li-Wei Zou, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Bo Sun, Ling Yang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Bufotalin (BFT), one of the naturally occurring bufodienolides, has multiple pharmacological and toxicological effects including antitumor activity and cardiotoxicity. This study aimed to character the metabolic pathway(s) of BFT and to identify the
Externí odkaz:
https://doaj.org/article/eabee42cdb1a406ca7305c2343efafb9
Autor:
Xiaobo Sun, Shuaipeng Lv, Hui Zhou, Lei Wang, Huijuan Zhu, Xiaojie Gong, Xin Yu, Yue Xu, Min Wang, Guibo Sun, Zi-Ru Dai, Haitao Liu
Publikováno v:
Communications Chemistry, Vol 2, Iss 1, Pp 1-10 (2019)
3-Trifluoromethylpyrazole and its derivatives are of major interest to both the agrochemical and pharmaceutical industry for their diverse biological activities. Reported routes for the synthesis of 3-trifluoromethylpyrazoles are hindered by poor reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b8f22c7097d692de0c824b4fcf30d4
http://link.springer.com/article/10.1038/s42004-019-0168-6
http://link.springer.com/article/10.1038/s42004-019-0168-6
Publikováno v:
Molecular and Cellular Probes. 43:1-5
Mitochondria play a central role in various critical cellular processes, including energy synthesis, energy supply and apoptosis. Panax notoginseng, a commonly used traditional Chinese medicine, has various pharmacological effects on the human body.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b69dcc62296bf0f3e83df3f038d817
https://doi.org/10.1016/j.mcp.2018.12.001
https://doi.org/10.1016/j.mcp.2018.12.001
Autor:
Yan, Kong, Ying, Li, Zi-Ru, Dai, Mei, Qin, He-Liang, Fan, Jun-Guang, Hao, Chen-Xiao, Zhang, Qiu-Ping, Zhong, Cen, Qi, Pei, Wang
Publikováno v:
Food Science & Nutrition
Hyperlipidemia an immense group of acquired or genetic metabolic disorders that is characterized by an excess of lipids in the bloodstream. Altogether, they have a high prevalence worldwide and constitute a major threat to human health. Glycosaminogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f67d6bde66683e546998429a4b83f80b
https://pubmed.ncbi.nlm.nih.gov/34532028
https://pubmed.ncbi.nlm.nih.gov/34532028
Autor:
Weijie Xie, Xi Dong, Xuelian Zhang, Chenyang Zhang, Ping Zhou, Xiaobo Sun, Zi-Ru Dai, Mu-Wen Qu, Guibo Sun
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Hyperglycaemia-induced retinal microvascular endothelial cell apoptosis is a critical and principle event in diabetic retinopathy (DR), which involves a series of complex processes such as mitochondrial dysfunction and oxidative stress. Ginsenoside R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe370b5dc6603b6b7f6524d30d6fe94d
https://doi.org/10.3389/fphar.2020.00695
https://doi.org/10.3389/fphar.2020.00695
Autor:
Le-Le Ding, Yang Yu, Zi-Miao Weng, Ping-Kun Liu, Xu-Dong Hou, Zi-Ru Dai, Yue-Hong Leng, Hui-Liang Li, Jie Hou, Guang-Bo Ge
Publikováno v:
International Journal of Biological Macromolecules. 118:2216-2223
Reduction of lipid absorption has been recognized as an attractive approach for the discovery of new drugs to treat obesity and overweight. The leave extract of Ginkgo biloba has been widely used for the treatment of metabolic diseases (such as hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf18e11470c46be9f7b7c2bbdbd546ba
https://doi.org/10.1016/j.ijbiomac.2018.07.085
https://doi.org/10.1016/j.ijbiomac.2018.07.085
Autor:
Xu-Dong Hou, Zi-Ru Dai, Le-Le Ding, Yue-Hong Leng, Jie Hou, Yang Yu, Zi-Miao Weng, Lingling Jin, Guang-Bo Ge, Yun-Feng Cao
Publikováno v:
Bioorganic Chemistry. 80:577-584
Pancreatic lipase (PL), a key enzyme responsible for the hydrolysis of triacylglycerides in the gastrointestinal tract, has been identified as the therapeutic target for the regulation of lipid absorption. In the present study, six major constituents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea83970a844a8f376a559ccbd7c4edf
https://doi.org/10.1016/j.bioorg.2018.07.011
https://doi.org/10.1016/j.bioorg.2018.07.011
Autor:
Dan-Dan Wang, Na Li, Yong Liu, Zi-Ru Dai, Da-Cheng Hao, Yi Zhang, Qiang Jin, Ling Yang, Hai-long Piao, Guang-Bo Ge
Publikováno v:
Toxicology in Vitro. 44:36-43
As the first selective EGFR tyrosine kinase inhibitor, gefitinib has been clinically demonstrated to be effective for certain cancer cell types with EGFR-active gene mutations. However, a number of gefitinib-associated adverse pulmonary events have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a16b0bc6e72b4d18e8098d59f8124c
https://doi.org/10.1016/j.tiv.2017.06.022
https://doi.org/10.1016/j.tiv.2017.06.022
Autor:
Jing Ning, Lei Feng, Jingnan Cui, Ling Yang, Hai-Ling Cheng, Qiang Jin, Yang Yu, Guang-Bo Ge, Zi-Ru Dai, Yan Li
Publikováno v:
Chemical Science. 8:2795-2803
The development of isoform-specific probe(s) for a target enzyme with multiple homologs is always challenging. Herein, a practical strategy was used to design and develop an isoform-specific probe for CYP1A1, a key cytochrome P450 isoenzyme involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31e810d466c4bcdc3b302fcdba9a29eb
https://doi.org/10.1039/c6sc03970g
https://doi.org/10.1039/c6sc03970g