Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Zhuyuan Chen"'
Publikováno v:
eLife, Vol 10 (2021)
ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction, and ischemia-induced neuronal injury. We report isolation and characterization of alpaca-derived nanobodies (Nbs) that specifically target human ASIC1a. Cryo-ele
Externí odkaz:
https://doaj.org/article/3015e42f8a4b4c0d9076d62eb3fb7ffc
Publikováno v:
eLife, Vol 8 (2019)
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open st
Externí odkaz:
https://doaj.org/article/45151b0abd764d61baee06f2cd535376
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:2852-2865
Serum-glucocorticoid-induced kinase-1 (SGK1) regulates ion homeostasis and promotes survival under stress conditions. The expression of SGK1 is under transcriptional and post-translational regulations that are frequently altered in cancer and immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3afa8a46bbb3c38139ab05c18c3354
https://doi.org/10.1111/jcmm.17300
https://doi.org/10.1111/jcmm.17300
Autor:
Yo Tanaka, Dahai Ren, Peng Wang, Changku Sun, Yixing Gou, Zheng You, Yaxiaer Yalikun, Zhuyuan Chen
Publikováno v:
Nanoscale. 13:17765-17774
Breast cancer is the most fatal disease among female cancers yet its detection still relies on needle biopsy. The unique physical and immune characteristics of breast cancer cells different from blood cells make them suitable to be employed as excell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a3d6b1630c929c000bf0551161941
https://doi.org/10.1039/d1nr04018a
https://doi.org/10.1039/d1nr04018a
Autor:
Chuanbo Qin, Bin Zheng, Junying Zeng, Zhuyuan Chen, Yikui Zhai, Angelo Genovese, Vincenzo Piuri, Fabio Scotti
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e50013dc5fddb4454f11622b53e5d12
https://doi.org/10.2139/ssrn.4224445
https://doi.org/10.2139/ssrn.4224445
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction, and ischemia-induced neuronal injury. We report isolation and characterization of alpaca-derived nanobodies (Nbs) that specifically target human ASIC1a. Cryo-ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e748c024311559c9918182092b6c800
https://doi.org/10.7554/elife.67115
https://doi.org/10.7554/elife.67115
A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels
Publikováno v:
The Journal of General Physiology
Chen et al. computationally model the open conformation of the hASIC1a channel to predict that mutations that eliminate channel selectivity cause a widening of the GAS belt. Their findings implicate the GAS belt diameter in channel kinetics and ion s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42c0396b8bc2a4b3ea83eee41966a63
https://pubmed.ncbi.nlm.nih.gov/34766968
https://pubmed.ncbi.nlm.nih.gov/34766968
Publikováno v:
Sensors and Actuators B: Chemical. 279:342-350
Real-time detection and visualization of the content and distribution of mRNA in living cells are important in molecular biology and can provide information about cell heterogeneity for clinical studies. Traditional mRNA detection methods require cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b59f91cbabc9c4bde65dc95f508b6693
https://doi.org/10.1016/j.snb.2018.10.007
https://doi.org/10.1016/j.snb.2018.10.007
Publikováno v:
The Journal of General Physiology
Acid-sensing ion channels (ASIC) play central roles in the central and peripheral nervous systems. In this paper, Chen et al. show that changes to a single arginine of a human ASIC both affect the efficacy of proton-mediated gating and delay the dese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5e379222e31cb1a8fe4986aa6125d6
https://doi.org/10.1085/jgp.202012802
https://doi.org/10.1085/jgp.202012802