Mechanism of EBV inducing anti-tumour immunity and its therapeutic use

Autor: Dereck W. Paul, Jonathan Stevens, Jerome Ritz, Indira Guleria, Qiang Ke, Kai W. Wucherpfennig, Harvey Cantor, Il-Kyu Choi, Hye-Jung Kim, Zhuting Hu, Zhe Wang, Stacey M. Fernandes, Baochun Zhang, Min Hong, Jennifer R. Brown

Publikováno v: Nature

Tumour-associated antigens (TAAs) comprise a large set of non-mutated cellular antigens recognized by T cells in human and murine cancers. Their potential as targets for immunotherapy has been explored for more than two decades1, yet the origins of T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b0d97689ec6ba81f1875bd51d85596
https://doi.org/10.1038/s41586-020-03075-w

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

Autor: Patrick C. Lee, Shuqiang Li, Charles H. Yoon, Jing Sun, Jason Pyrdol, Zoe B. Ciantra, J. Bryan Iorgulescu, Jinyan Liu, Donna E. Leet, Anita Giobbie-Hurder, Donna Neuberg, Satyen H. Gohil, Teddy Huang, Edward F. Fritsch, Wandi Zhang, Adrienne M. Luoma, Mohamed Uduman, Siranush Sarkizova, Kai W. Wucherpfennig, Giacomo Oliveira, Dan H. Barouch, Liudmila Elagina, Nir Hacohen, Oriol Olive, Lars Rønn Olsen, Zhuting Hu, Elizabeth I. Buchbinder, Derin B. Keskin, Sachet A. Shukla, Robert A. Redd, Bradley L. Pentelute, Patrick A. Ott, Scott J. Rodig, Catherine J. Wu, Keerthi Shetty, Kenneth J. Livak, Pavan Bachireddy, Rosa Lundbye Allesøe, Rebecca L. Holden, Lauren Peter, Juliet Forman

Publikováno v: Hu, Z, Leet, D E, Allesøe, R L, Oliveira, G, Li, S, Luoma, A M, Liu, J, Forman, J, Huang, T, Iorgulescu, J B, Holden, R, Sarkizova, S, Gohil, S H, Redd, R A, Sun, J, Elagina, L, Giobbie-Hurder, A, Zhang, W, Peter, L, Ciantra, Z, Rodig, S, Olive, O, Shetty, K, Pyrdol, J, Uduman, M, Lee, P C, Bachireddy, P, Buchbinder, E I, Yoon, C H, Neuberg, D, Pentelute, B L, Hacohen, N, Livak, K J, Shukla, S A, Olsen, L R, Barouch, D H, Wucherpfennig, K W, Fritsch, E F, Keskin, D B, Wu, C J & Ott, P A 2021, ' Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma ', Nature Medicine, vol. 27, no. 3, pp. 515-525 . https://doi.org/10.1038/s41591-020-01206-4
Nat Med
Hu, Z, Leet, D E, Allesøe, R L, Oliveira, G, Li, S, Luoma, A M, Liu, J, Forman, J, Huang, T, Iorgulescu, J B, Holden, R, Sarkizova, S, Gohil, S H, Redd, R A, Sun, J, Elagina, L, Giobbie-Hurder, A, Zhang, W, Peter, L, Ciantra, Z, Rodig, S, Olive, O, Shetty, K, Pyrdol, J, Uduman, M, Lee, P C, Bachireddy, P, Buchbinder, E I, Yoon, C H, Neuberg, D, Pentelute, B L, Hacohen, N, Livak, K J, Shukla, S A, Olsen, L R, Barouch, D H, Wucherpfennig, K W, Fritsch, E F, Keskin, D B, Wu, C J & Ott, P A 2021, ' Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma ', Nature Medicine, vol. 27, pp. 515-525 . https://doi.org/10.1038/s41591-020-01206-4

Personal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the long-term effects of such a vaccine, we evaluated the clinical outcome and circulating immune respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb0d71266b86a21a801f1370e5a7c0f
https://orbit.dtu.dk/en/publications/380c54f4-6c21-4388-8a77-6cbca07d517d

A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens

Autor: Donna E. Leet, Atsushi Muraguchi, Donna Neuberg, Edward F. Fritsch, Ute E. Burkhardt, Christina Chen, Annabelle J. Anandappa, Wandi Zhang, Louise Williams, Oriol Olive, Diana Tabbaa, Zhuting Hu, Derin B. Keskin, Scott Steelman, Jintaek Kim, Kenneth J. Livak, Patrick A. Ott, Catherine J. Wu, Hiroyuki Kishi, Sachet A. Shukla, Jonathan Stevens, Indira Guleria, Jing Sun, Nir Hacohen, William J. Lane, David J. Bozym

Publikováno v: Blood. 132(18)

Recent studies have highlighted the promise of targeting tumor neoantigens to generate potent antitumor immune responses and provide strong motivation for improving our understanding of antigen-T-cell receptor (TCR) interactions. Advances in single-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840bef4ba348afefdc6d13c269f975a0
https://pubmed.ncbi.nlm.nih.gov/30385487

CD4+ T-cell dependence of primary CD8+ T-cell response against vaccinia virus depends upon route of infection and viral dose

Autor: Zhuting Hu, Edward J. Usherwood, Michael J. Molloy

Publikováno v: Cellular & Molecular Immunology. 13:82-93

CD4(+) T-cell help (CD4 help) plays a pivotal role in CD8(+) T-cell responses against viral infections. However, the role in primary CD8(+) T-cell responses remains controversial. We evaluated the effects of infection route and viral dose on primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35395c7f4de132745f776b4205c5273
https://doi.org/10.1038/cmi.2014.128

Abstract A010: Personalized neoantigen-targeting vaccines for high-risk melanoma generate epitope spreading

Autor: Rebecca L. Holden, Karl R. Clauser, Wandi Zhang, Sachet A. Shukla, Jing Sun, Siranush Sarkizova, Bradley L. Pentelute, Derin B. Keskin, Nir Hacohen, Catherine J. Wu, Edward F. Fritsch, Zhuting Hu, Susan Klaeger, Steven A. Carr, Donna E. Leet, Patrick A. Ott

Publikováno v: Cancer Immunology Research. 7:A010-A010

Cancer vaccines have been envisioned as a key tool for generating effective cancer therapy. Tumor neoantigens are ideal targets because of their exquisite tumor-specific expression (arising from somatic mutations of the tumor) and high level of immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a29046c647dd6c50da05a995d9d49c1b
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a010